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Caryocar brasiliense peel ethanolic extract has neuroprotective potential and reduces the activation of ERK1/2 in the ischemia and reperfusion brain acute phase in the rat
Oxidative stress induced by ischemia and reperfusion (I/R) injury results in cell death by necrosis or apoptosis and triggers the activation of different intracellular pathways, such as mitogen-activated protein activated kinases. Pequi (Caryocar brasiliense) peel, residue of a fruit from Brazilian savannah-like vegetation, has phenolic compounds that have been demonstrated to have antioxidant effects in vitro. The present study aimed to evaluate the neuroprotective effects of C. brasiliense peel ethanolic extract (CBPE) against transient global I/R injury in the rat brain.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2023 Category: Neurology Authors: Marina Pacheco Miguel, Liliana Borges de Menezes, Leandro Guimar ães Franco, Mariana Moreira Andrascko, Ana Carolina Brigolin Parize, Juliana Carvalho de Almeida Borges, Lorena Lima Barboza Guimarães, Danilo Rezende e Silva, Suzana da Costa Santos, Eugà Source Type: research

Implementation of a Brazilian Cardioprotective nutritional (BALANCE) program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicentre trial
ConclusionsThe BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD, and had no significant effect on the incidence of cardiovascular events or death.
Source: American Heart Journal - June 21, 2019 Category: Cardiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research