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Inducing ketogenesis via an enteral formulation in patients with acute brain injury:a phase II study.
Conclusion: In patients with acute brain injury, an enterally administered ketogenic formulation increased plasma ketone concentrations, was well tolerated, did not impact on cerebral hemodynamics and can be safely administered.Clinical trial registered at the Australian New Zealand Clinical Trials Registry (ACTRN12616000332426)Abbreviations: BHB: betahydroxybutyrate; AcAc: acetoacetate; ABI: acute brain injury; TBI: traumatic brain injury; CSF: cerebrospinal fluid; SAH: subarachnoid injury; CVA: cerebrovascular accidents; ICP: intracranial pressure; CPP: cerebral perfusion pressure; ICU: intensive care unit; EVD: external...
Source: Neurological Research - February 28, 2020 Category: Neurology Tags: Neurol Res Source Type: research

When does life end? New organ donation strategy fuels debate
On a chilly holiday Monday in January 2020, a medical milestone passed largely unnoticed. In a New York City operating room, surgeons gently removed the heart from a 43-year-old man who had died and shuttled it steps away to a patient in desperate need of a new one. More than 3500 people in the United States receive a new heart each year. But this case was different—the first of its kind in the country. “It took us 6 months to prepare,” says Nader Moazami, surgical head of heart transplantation at New York University (NYU) Langone Health, where the operation took place. The run-up included oversight from an ethi...
Source: ScienceNOW - May 11, 2023 Category: Science Source Type: news

The Great Contrast Shortage of 2022 —Lessons learnt in Australia
ConclusionOur findings demonstrate that the IBCM shortage crisis had a very significant impact on the delivery of healthcare. While V/Q scans could (partially) substitute for CTPA studies in suspected pulmonary emboli, there appeared to be no valid alternative for CTNA studies in stroke calls. The unexpected and critical shortage of IBCM forced healthcare professionals to conserve resources, prioritise indications, triage patients based on risk, explore alternate imaging strategies and prepare for similar events recurring in the future.
Source: Journal of Medical Imaging and Radiation Oncology - May 18, 2023 Category: Radiology Authors: Giles Kisby, James H Seow, Greg Schie, Constantine C Phatouros, Kay ‐Vin Lam, Tracey Muir, Sally Burrows, Paul M Parizel Tags: Medical Imaging —Original Article Source Type: research

The association between intraoperative cardiopulmonary bypass power and complications after cardiac surgery
CONCLUSIONS: This study suggests that MAP during cardiopulmonary bypass, but not power or flow, was an independent risk factor for adverse renal outcomes for cardiac surgical patients.PMID:37442644 | DOI:10.1177/02676591231187958
Source: Perfusion - July 13, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Victor Hui Kwok M Ho Rebecca Hahn Brian Wright Robert Larbalestier Warren Pavey Source Type: research

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