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Prevalence of atrial fibrillation in a regional Victoria setting, findings from the crossroads studies (2001-2003 and  2016-2018)
CONCLUSION: The prevalence of AF among community-based participants in regional Victoria was similar to predominantly metropolitan-based studies, and was unchanged over time despite increased rates of risk factors. Electrocardiogram rhythm strip investigation was successfully utilised, and particularly benefited from physician overview.PMID:35938603 | DOI:10.1111/ajr.12914
Source: The Australian Journal of Rural Health - August 8, 2022 Category: Rural Health Authors: Kristen Glenister Leslie Bolitho Lisa Bourke David Simmons Source Type: research

Oral Anticoagulant Use in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Review of the Evidence With Recommendations for Australian Clinical Practice
Chronic kidney disease is common in patients with atrial fibrillation (AF) and is associated with heightened risks of stroke/systemic embolisation and bleeding. In this review we outline the evidence for AF stroke prevention in kidney disease, identify current knowledge gaps, and give recommendations for anticoagulation at various stages of chronic kidney disease.Overall, anticoagulation is underused. Warfarin use becomes increasingly difficult with advancing kidney disease, with difficulty maintaining international normalised ratio (INR) in therapeutic range, increased risk of intracranial and fatal bleeding compared to n...
Source: Heart, Lung and Circulation - November 3, 2022 Category: Cardiology Authors: Christopher Hammett, Sunil V. Badve, Peter G. Kerr, Huyen A. Tran, Benjamin K. Dundon, Sidney Lo, Andrew Wong, Joanne E. Joseph, Jenny Deague, Vlado Perkovic Tags: Review Source Type: research

Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (STAREE trial)
Introduction The world is undergoing a demographic transition to an older population. Preventive healthcare has reduced the burden of chronic illness at younger ages but there is limited evidence that these advances can improve health at older ages. Statins are one class of drug with the potential to prevent or delay the onset of several causes of incapacity in older age, particularly major cardiovascular disease (CVD). This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, a randomised double-blind placebo-controlled trial examining the effects of statins in community dwelling o...
Source: BMJ Open - April 3, 2023 Category: General Medicine Authors: Zoungas, S., Curtis, A., Spark, S., Wolfe, R., McNeil, J. J., Beilin, L., Chong, T. T.-J., Cloud, G., Hopper, I., Kost, A., Nelson, M., Nicholls, S. J., Reid, C. M., Ryan, J., Tonkin, A., Ward, S. A., Wierzbicki, A., On behalf of STAREE investigator group Tags: Open access, Cardiovascular medicine Source Type: research

Older People With Atrial Fibrillation and Hypertension Are at Higher Risk of Poor Blood Pressure Control in Australian Primary Care
This study explored factors that influence BP control in AF patients with hypertension managed in Australian primary care, with a focus on older age.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: R. Trivedi, T. Shaw, C. Chow, L. Laranjo Source Type: research

Changes in Oral Anticoagulant Prescribing for Stroke Prevention in Patients with Atrial Fibrillation
This study aimed to compare anticoagulation practice in Australia during the pre- and post-direct oral anticoagulant (DOAC) eras. Between January 2011 and July 2015, patients with non-valvular AF (NVAF) admitted to the Royal Hobart Hospital, Tasmania, Australia, were retrospectively reviewed. The pre- and post-DOAC era cohorts included admissions from January 2011 to July 2013 and August 2013 to July 2015, respectively.
Source: The American Journal of Cardiology - July 14, 2017 Category: Cardiology Authors: Endalkachew Admassie, Leanne Chalmers, Luke R. Bereznicki Source Type: research

The representativeness of direct oral anticoagulant clinical trials to hospitalized patients with atrial fibrillation
ConclusionsThe apixaban and dabigatran trials may be the most representative of hospitalized patients with AF. The DOAC trial results can readily be extrapolated to, and guide prescribing for, at least two thirds of patients discharged from a large metropolitan health service in Australia.
Source: European Journal of Clinical Pharmacology - July 27, 2017 Category: Drugs & Pharmacology Source Type: research

Bleeding-related admissions in patients with atrial fibrillation receiving antithrombotic therapy: results from the Tasmanian Atrial Fibrillation (TAF) study
ConclusionThe overall rate of bleeding in this cohort was low relative to similar observational studies. The rate of major bleeding was higher in patients prescribed warfarin compared to DOACs, with a similar rate of major bleeding for DOACs and antiplatelet agents. Our findings suggest potential to strategies to reduce bleeding include using DOACs in preference to warfarin, and avoiding multiple antithrombotic therapies in patients with AF.
Source: European Journal of Clinical Pharmacology - September 22, 2017 Category: Drugs & Pharmacology Source Type: research

Dedicated warfarin care programme results in superior warfarin control in Queensland, Australia
ConclusionAustralian warfarin control was good when managed by either GP or WCP, but WCP management increased TTR by 13%. Dedicated warfarin programmes can improve warfarin control and optimise therapy for patients.
Source: International Journal of Clinical Practice - January 9, 2018 Category: Internal Medicine Authors: Nijole Bernaitis, Tony Badrick, Shailendra Anoopkumar ‐Dukie Tags: ORIGINAL PAPER Source Type: research

The impact of non-vitamin K antagonist oral anticoagulants (NOACs) on anticoagulation therapy in rural Australia.
CONCLUSIONS: In rural WA, about one-third of patients with an indication for anticoagulation therapy receive NOACs, but one-third of patients with AF and at risk of stroke received no anticoagulant therapy, and may benefit from NOAC therapy. PMID: 29320668 [PubMed - in process]
Source: Medical Journal of Australia - January 11, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

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