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Therapeutic Potential of Saffron ( < em > Crocus sativus < /em > L.) in Ischemia Stroke
Evid Based Complement Alternat Med. 2021 Mar 2;2021:6643950. doi: 10.1155/2021/6643950. eCollection 2021.ABSTRACTStroke is the second leading cause of death and a main cause of disability worldwide. The majority (approximately 80%) of strokes are ischemic. Saffron (Crocus sativus L.) has been considered for medicinal purposes since ancient times. Pharmacological effects of saffron are attributed to the presence of crocin, crocetin, picrocrocin, and safranal. In the present review, we summarized the reported neuroprotective effects of saffron and its active constituents against cerebral ischemia stroke. Saffron and its comp...
Source: Evidence-based Complementary and Alternative Medicine - March 22, 2021 Category: Complementary Medicine Authors: Shakiba Azami Zahra Shahriari Samira Asgharzade Tahereh Farkhondeh Mahmood Sadeghi Fatemeh Ahmadi Mohammad Mahdi Vahedi Fatemeh Forouzanfar Source Type: research

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research