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MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice
CONCLUSIONS: These results suggest that MAGT1 and TRPC6 are functionally linked. Therefore, deficiency or impaired functionality of MAGT1 could be a potential risk factor for arterial thrombosis and stroke.PMID:37381987 | DOI:10.1161/ATVBAHA.122.318115
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 29, 2023 Category: Cardiology Authors: Sanjeev Kiran Gotru Elmina Mammadova-Bach Georgios Sogkas Michael K Schuhmann Karen Schmitt Peter Kraft Sabine Herterich Medina Mamtimin Akif Pinarci Sarah Beck Simon Stritt Han Chao Pengxuan Ren Jean-No ël Freund Christian Klemann Felix C Ringshausen Jo Source Type: research

Hypoxia-Preconditioned Bone Marrow Mesenchymal Stem Cells Improved Cerebral Collateral Circulation and Stroke Outcome in Mice
CONCLUSIONS: BMSCs increased collateral circulation and improved poststroke outcomes, through the upregulation of Rabep2. These effects were enhanced by hypoxic preconditioning.PMID:37226732 | DOI:10.1161/ATVBAHA.122.318559
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 25, 2023 Category: Cardiology Authors: Hao Tian Xinxuan Yang Jiahui Zhao Xiran Liu Xin Liu Yuan Cai Alexandra Wehbe Yuchuan Ding Shanping Yu Ling Wei Liping Liu Source Type: research

Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.
CONCLUSIONS: CD8+ TSCM cells are increased in humans with high CVD. As these TSCM cells promote atherosclerosis, targeting them may attenuate atherosclerotic plaque progression. PMID: 33054398 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 15, 2020 Category: Cardiology Authors: Padgett LE, Dinh HQ, Wu R, Gaddis DE, Araujo DJ, Winkels H, Nguyen A, McNamara CA, Hedrick CC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells.
CONCLUSIONS: These cells provide novel insight into ApoE4-mediated endothelial dysfunction and provide a new platform to test potential therapies for vascular disorders. PMID: 31315437 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - July 17, 2019 Category: Cardiology Authors: Rieker C, Migliavacca E, Vaucher A, Mayer FC, Baud G, Marquis J, Charpagne A, Hegde N, Guignard L, McLachlan M, Pooler AM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

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