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Fertility preservation in women with sickle cell disease prior to curative therapy with stem cell transplant: a case series
Sickle cell disease (SCD) is an inherited hemoglobinopathy affecting approximately 100,000 Americans (1). Due to the pathognomonic sickling of red blood cells, individuals with SCD are at risk of venous thromboembolism, hemolytic anemia, stroke, pain crises, infection and end organ damage (2). Hematopoietic stem cell transplant (HSCT), while curative, can also lead to gonadal dysfunction and thereby ovarian insufficiency due to the associated myeloablative and radiative conditioning regimens (3).
Source: Fertility and Sterility - July 1, 2023 Category: Reproduction Medicine Authors: M. Yamasaki, P. Lindner, A. Decherney, T. Spitzer Source Type: research

P –358 Characteristics of patients with inherited thrombophilia and anticoagulant treatment in repeated implantation failure (RIF) and recurrent pregnancy loss (RPL)
AbstractStudy questionDo patients with inherited thrombophilia associated to RIF and RPL benefit from anticoagulant therapy?Summary answerLow molecular weight heparin (LMWH) in patients with medium and high risk of hereditary thrombophilia, associated with RIF could improve the reproductive prognosis.What is known alreadyThrombophilia is a condition that can be acquired and/or inherited genetically, that is characterized by the predisposition of patients to form venous and arterial thromboembolic events. Inherited thrombophilia has been associated with different complications during pregnancy, such as RPL. Genetic variants...
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research

Effect of desogestrel 75 µg on headache frequency and intensity in women with migraine: a prospective controlled trial.
CONCLUSION: These data demonstrate for the first time in a prospective controlled setting that daily use of the progestin desogestrel is associated with a decrease in migraine frequency, migraine intensity and pain medication use in women with migraine, with and without aura, who had previously been experiencing at least three days of migraine per month. TRIAL REGISTRATION: The study is registered in the University of Zürich database ( www.research-projects.uzh.ch/unizh.htm ). PMID: 31094588 [PubMed - as supplied by publisher]
Source: The European Journal of Contraception and Reproductive Health Care - May 15, 2019 Category: Reproduction Medicine Authors: Merki-Feld GS, Imthurn B, Gantenbein AR, Sandor P Tags: Eur J Contracept Reprod Health Care Source Type: research

Low-dose oral contraceptive-induced acute myocardial infarction.
CONCLUSION: Low-dose OCs may also be responsible for acute MI even in a very young female without any cardiovascular risk factors. Therefore, the clinicians should be aware of this mortal events during follow-up of the patient using OCs. PMID: 27608962 [PubMed - as supplied by publisher]
Source: The European Journal of Contraception and Reproductive Health Care - September 8, 2016 Category: Reproduction Medicine Authors: Aslan AN, Süygün H, Sivri S, Keleş T Tags: Eur J Contracept Reprod Health Care Source Type: research

Current recommendations: what is the clinician to do?
Menopausal hormone therapy (HT) has complex biologic effects but continues to have an important clinical role in the management of vasomotor and other menopausal symptoms. The rational use of menopausal HT requires balancing the potential benefits and risks of treatment. Findings from the Women's Health Initiative (WHI) and other randomized clinical trials have helped to clarify the benefits and risks of HT and have provided insights to improve decision making. Several clinical characteristics have utility in identifying women for whom benefits of HT are likely to outweigh the risks. Age and time since menopause are strong...
Source: Fertility and Sterility - March 31, 2014 Category: Reproduction Medicine Authors: JoAnn E. Manson Tags: Views and reviews Source Type: research