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Specialty: Neurology
Condition: Thrombosis

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Total 3681 results found since Jan 2013.

Early Experience With Tenecteplase at a Comprehensive Stroke Center
Purpose of Review Tenecteplase has been studied and recommended as an alternative thrombolytic agent in patients with acute stroke. A brief review of clinical trials and guidelines pertinent to our clinical decision algorithm is described. This is followed by operational steps that were made to create and implement a clinical pathway based on available evidence in which tenecteplase is used in select patients with stroke at our comprehensive stroke center. Recent Findings A number of patients have been treated at our center with IV tenecteplase. A case is presented to illustrate the successful implementation of this new p...
Source: Neurology Clinical Practice - December 13, 2021 Category: Neurology Authors: Panezai, S., Dubinsky, I., Sahito, S., Gadallah, N., Suhan, L., Mehta, S., Kirmani, J. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Infarction Review Source Type: research

Prognostic Value of Serum Cardiac Troponin in Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis
Ischemic stroke (IS), defined as a sudden reduction of the blood flow to the brain due to lack of blood supply to a vessel caused by thrombosis or embolism, is the second leading cause of death and third leading cause of death and disability combined worldwide.1 Stroke shares several risk factors with cardiac diseases, and approximately 25% of the patients with recent stroke had a medical history of coronary artery disease. On the other hand, cardiac adverse events are common complications after acute ischemic stroke (AIS), occurring in up to 20% of the patients during the first 2-3 days after stroke onset.
Source: Journal of Stroke and Cerebrovascular Diseases - March 24, 2022 Category: Neurology Authors: Yao Zhang, Menglu Ouyang, Jianting Qiu, Xiaopan Cao, Bing Xu, Yi Sui Source Type: research

Intra‐arterial thrombolysis vs. standard treatment or intravenous thrombolysis in adults with acute ischemic stroke: a systematic review and meta‐analysis
Conclusions This analysis finds a modest benefit of intra‐arterial thrombolysis over standard treatment, although it does not find a clear benefit of intra‐arterial thrombolysis over intravenous thrombolysis in acute ischemic stroke patients. However, few trials, small sample sizes, and indirectness limit the strength of evidence.
Source: International Journal of Stroke - January 7, 2013 Category: Neurology Authors: Julian Nam, He Jing, Daria O'Reilly Tags: Systematic Review Source Type: research

CLOTBUST-Hands Free: Initial Safety Testing of a Novel Operator-Independent Ultrasound Device in Stroke-Free Volunteers Clinical Sciences
Conclusions— Our novel device was well tolerated by stroke-free volunteers and did not cause any neurological dysfunction nor did it affect blood brain barrier integrity. The safety and efficacy of the device are now being tested in stroke patients receiving intravenous tissue-type plasminogen activator in phase II–III clinical trials.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Barlinn, K., Barreto, A. D., Sisson, A., Liebeskind, D. S., Schafer, M. E., Alleman, J., Zhao, L., Shen, L., Cava, L. F., Rahbar, M. H., Grotta, J. C., Alexandrov, A. V. Tags: Other Treatment, Acute Cerebral Infarction, Doppler ultrasound, Transcranial Doppler etc. Clinical Sciences Source Type: research

Toward a better understanding of PFO and stroke risk
A patent foramen ovale (PFO) is a remnant of the fetal circulation and may be found in approximately 25% of adults.1 Multiple case-control studies have demonstrated an association between PFO and cryptogenic ischemic stroke, particularly in younger patients.2 The mechanism for the association is presumed to be venous thromboembolism through the PFO and into the cerebral circulation (i.e., paradoxical embolization).3 Randomized studies of percutaneous PFO closure devices for secondary stroke prevention have been in progress for years with slow enrollment because of off-label use of atrial septal defect closure devices.4,5 T...
Source: Neurology - August 12, 2013 Category: Neurology Authors: Messe, S. R., Kernan, W. N. Tags: Stroke in young adults, Stroke prevention, Prognosis, Embolism EDITORIALS Source Type: research

Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study Brief Reports
Conclusions— Discontinuation of compressive stockings did not increase venous thromboembolism incidence. There was a trend toward more deep vein thrombosis and fewer PEs after CLOTS, which might be because of increased clinical vigilance in the diagnosis of deep vein thrombosis, but a chance variation cannot be excluded.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Jain, P., Ward, E., Nevatte, T., Roffe, C. Tags: Deep vein thrombosis Brief Reports Source Type: research

Balance of Symptomatic Pulmonary Embolism and Symptomatic Intracerebral Hemorrhage with Low-dose Anticoagulation in Recent Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Conclusions: Prophylactic/low-dose heparin increased sICH by more than they reduced sPE in patients with recent ischemic stroke. Therefore, their routine acute use cannot be recommended, but they may still be relevant in patients at very high risk of PE (eg, morbid obesity, previous venous thromboembolism, and inherited thrombophilia) or if started later, although trials have not assessed these issues.
Source: Journal of Stroke and Cerebrovascular Diseases - April 19, 2012 Category: Neurology Authors: Chamila M. Geeganage, Nikola Sprigg, Matthew W. Bath, Philip M.W. Bath Tags: Original Articles Source Type: research

Decompressive Hemicraniectomy for Malignant Hemispheric Stroke in the Elderly: Comparison of Outcomes between Individuals 61-70 and >70 Years of Age
Conclusions: We suggest that the efficacy of DHC in malignant hemispheric stroke patients between 61 and 70 years of age be further investigated in future randomized trials. By contrast, it appears unlikely that patients>70 years of age would benefit from DHC.
Source: Journal of Stroke and Cerebrovascular Diseases - March 13, 2013 Category: Neurology Authors: Joji Inamasu, Takafumi Kaito, Takeya Watabe, Tsukasa Ganaha, Yasuhiro Yamada, Teppei Tanaka, Shuei Imizu, Takuro Hayashi, Motoharu Hayakawa, Yoko Kato, Yuichi Hirose Tags: Original Articles Source Type: research

Prehospital factors determining regional variation in thrombolytic therapy in acute ischemic stroke
ConclusionsThese results suggest that the larger proportion of patients arriving within 4·5 h in the centralized model might be related to a lower threshold to use emergency services to transport stroke patients and partly to preferential referral of thrombolysis candidates.
Source: International Journal of Stroke - December 23, 2013 Category: Neurology Authors: Maarten M. H. Lahr, Patrick C. A. J. Vroomen, Gert‐Jan Luijckx, Durk‐Jouke Zee, Ronald Vos, Erik Buskens Tags: Research Source Type: research

Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Conclusions— In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2–VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Roldan, V., Vilchez, J. A., Manzano-Fernandez, S., Jover, E., Galvez, J., Puche, C. M., Valdes, M., Vicente, V., Lip, G. Y. H., Marin, F. Tags: Arterial thrombosis, Coumarins, Anticoagulants Clinical Sciences Source Type: research

Association Between Arterial Calcifications and Nonlacunar and Lacunar Ischemic Strokes Clinical Sciences
Conclusions— The only difference we found between nonlacunar and lacunar strokes was a higher calcification volume in the aortic arch in nonlacunar strokes. Our findings only partially confirm the notion of distinct etiologies and suggest that the potential role of other plaque components, plaque morphology, and aortic arch calcifications in ischemic stroke subtypes awaits further evaluation.
Source: Stroke - February 24, 2014 Category: Neurology Authors: van Dijk, A. C., Fonville, S., Zadi, T., van Hattem, A. M. G., Saiedie, G., Koudstaal, P. J., van der Lugt, A. Tags: Pathophysiology, Acute Stroke Syndromes Clinical Sciences Source Type: research

Dilemma of Indication for Thrombolysis in a Patient with Acute Ischemic Stroke Treated with a Novel Oral Anticoagulant
We report the case of a patient treated with dabigatran who developed acute ischemic stroke and was considered for thrombolysis. Because of the prolonged thrombin time (TT), thrombolysis was not performed. Repeated coagulation tests 5 days after stroke, with unchanged anticoagulant (dabigatran) treatment, found 2-fold higher TT and activated partial thromboplastin time (APTT) compared with the values found in the acute stage. Routine coagulation tests (TT and APTT) do not reliably reflect the coagulation features of a patient; therefore, there is an urgent need to develop reliable biomarkers and an adequate guideline to ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: András Folyovich, Viktória Varga, Katalin A. Béres-Molnár, Károly Vadasdi, Dániel Bereczki Tags: Case Reports Source Type: research

Combination Treatment With N-Acetyl-Seryl-Aspartyl-Lysyl-Proline and Tissue Plasminogen Activator Provides Potent Neuroprotection in Rats After Stroke Basic Sciences
Conclusions— Our data indicate that AcSDKP passes the blood–brain barrier, and that treatment of acute stroke with AcSDKP either alone at 1 hour or in combination with tPA at 4 hours of the onset of stroke is effective to reduce ischemic cell damage in a rat model of embolic stroke. Inactivation of TGF-β and NF-B signaling by AcSDKP in the neurovascular unit may underlie the neuroprotective effect of AcSDKP.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Zhang, L., Chopp, M., Teng, H., Ding, G., Jiang, Q., Yang, X. P., Rhaleb, N. E., Zhang, Z. G. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research

Thrombolytic Treatment for Acute Ischemic Stroke Patients with History of Migraine Headaches (P4.223)
Conclusion: Patients with migraine headaches receiving IV rt-PA treatment for acute ischemic stroke appear to have a lower rates of death and disability most likely related to their decreased rates of intracerebral hemorrhage.Disclosure: Dr. Malik has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Nickles has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Malik, A., Adil, M., Chaudhry, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Management of acute stroke in patients taking novel oral anticoagulants
Each year, 1·0–2·0% of individuals with atrial fibrillation and 0·1–0·2% of those with venous thromboembolism who are receiving one of the novel oral anticoagulants (dabigatran, rivaroxaban, or apixaban) can be expected to experience an acute ischemic stroke. Additionally, 0·2–0·5% of individuals with atrial fibrillation who are receiving one of the novel oral anticoagulants can be expected to experience an intracranial hemorrhage. This opinion piece addresses the current literature and offers practical approaches to the management of patients receiving novel oral anticoagulants who present with an ischemic or ...
Source: International Journal of Stroke - June 1, 2014 Category: Neurology Authors: Graeme J. Hankey, Bo Norrving, Werner Hacke, Thorsten Steiner Tags: Review Source Type: research