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Specialty: Hematology
Condition: Thrombosis
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Total 1625 results found since Jan 2013.
Age at smoking initiation and smoking cessation influence the incidence of stroke in China: a 10-year follow-up study
In conclusion, we found that current smokers had a higher stroke risk than never smokers, and the risk increased with a younger age at smoking in itiation. Smoking cessation can reduce the risk for stroke, especially could benefit from cessation at a younger age.
Source: Journal of Thrombosis and Thrombolysis - April 26, 2023 Category: Hematology Source Type: research
Anticoagulation practices and complications associated with Impella ® support at an advanced cardiac center in the Middle East gulf region
AbstractAnticoagulation during Impella ® support is a challenge due to its complications and inconsistent practice across the globe. This observational, retrospective chart review included all patients with Impella® support at our advanced cardiac center at a quaternary care hospital in the Middle East gulf region. The study was conduc ted over six years (2016–2022), a time period during which manufacturer recommendations for purge solution, anticoagulation protocols as well as Impella® place in therapy and utilization were all evolving. We aimed to evaluate the efficacy of different anticoagulation practices and asso...
Source: Journal of Thrombosis and Thrombolysis - April 25, 2023 Category: Hematology Source Type: research
The pathogenesis of aging-induced left atrial appendage thrombus formation and cardioembolic stroke in mice is influenced by inflammation-derived matrix metalloproteinases
Elderly people without atrial fibrillation (AF) still have a high incidence of cardioembolic stroke, suggesting that thrombus formation within the left atrial appendage (LAA) may also occur in an AF-independent manner. In the present study, we explored the potential mechanisms for aging-induced LAA thrombus formation and stroke in mice. We monitored stroke events in 180 aging male mice (14 –24 months) and assessed left atrium (LA) remodeling by echocardiography at different ages. Mice that had stroke were implanted with telemeters to confirm AF.
Source: Thrombosis Research - April 25, 2023 Category: Hematology Authors: Ruopeng Tan, Mengyang Yuan, Lin Wang, Jingjie Liu, Guinan Jiang, Jiawei Liao, Yun-Long Xia, Xiaomeng Yin, Yang Liu Source Type: research
Editorial: The Optimal Management for People with Acute Stroke and Minor Deficits - Intravenous Thrombolysis or Medical Management?
Thromb Haemost. 2023 Apr 19. doi: 10.1055/a-2077-5642. Online ahead of print.ABSTRACTNo Abstract.PMID:37075783 | DOI:10.1055/a-2077-5642
Source: Thrombosis and Haemostasis - April 19, 2023 Category: Hematology Authors: Alan Cameron Azmil H Abdul-Rahim Source Type: research
Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice
CONCLUSION: Patients with AF and active cancer experience high rates of thromboembolic and bleeding complications, underlying the complexity of anticoagulant management in these patients. Our data suggest that the presence of cancer is an important factor in determining the indication for anticoagulants in patients with a low CHA2DS2-VASc score.PMID:37063771 | PMC:PMC10099322 | DOI:10.1016/j.rpth.2023.100096
Source: Thrombosis and Haemostasis - April 17, 2023 Category: Hematology Authors: Gordon Chu Jaap Seelig Suzanne C Cannegieter Hans Gelderblom Marcel M C Hovens Menno V Huisman Tom van der Hulle Serge A Trines Andr é J Vlot Henri H Versteeg Martin E W Hemels Frederikus A Klok Source Type: research
Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation
CONCLUSION: In patients with AF undergoing catheter ablation, the LAA demonstrated increased thrombin generation compared with the LA. This finding might contribute to the understanding of why the LAA is more predisposed to thrombus formation than the LA.CLINICAL TRIALS REGISTRATION: NCT03795883.PMID:37063762 | PMC:PMC10099305 | DOI:10.1016/j.rpth.2023.100127
Source: Thrombosis and Haemostasis - April 17, 2023 Category: Hematology Authors: Adi Elias Yara Khoury Faheem Shehadeh Gilat Ron Monther Boulos Jeries Nashashibi Robert Zukermann Mazen Elias Lior Gepstein Mahmoud Suleiman Source Type: research
Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice
CONCLUSION: Patients with AF and active cancer experience high rates of thromboembolic and bleeding complications, underlying the complexity of anticoagulant management in these patients. Our data suggest that the presence of cancer is an important factor in determining the indication for anticoagulants in patients with a low CHA2DS2-VASc score.PMID:37063771 | PMC:PMC10099322 | DOI:10.1016/j.rpth.2023.100096
Source: Thrombosis and Haemostasis - April 17, 2023 Category: Hematology Authors: Gordon Chu Jaap Seelig Suzanne C Cannegieter Hans Gelderblom Marcel M C Hovens Menno V Huisman Tom van der Hulle Serge A Trines Andr é J Vlot Henri H Versteeg Martin E W Hemels Frederikus A Klok Source Type: research
Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation
CONCLUSION: In patients with AF undergoing catheter ablation, the LAA demonstrated increased thrombin generation compared with the LA. This finding might contribute to the understanding of why the LAA is more predisposed to thrombus formation than the LA.CLINICAL TRIALS REGISTRATION: NCT03795883.PMID:37063762 | PMC:PMC10099305 | DOI:10.1016/j.rpth.2023.100127
Source: Thrombosis and Haemostasis - April 17, 2023 Category: Hematology Authors: Adi Elias Yara Khoury Faheem Shehadeh Gilat Ron Monther Boulos Jeries Nashashibi Robert Zukermann Mazen Elias Lior Gepstein Mahmoud Suleiman Source Type: research
The interaction effect of transfusion history and previous stroke history on the risk of venous thromboembolism in stroke patients: a prospective cohort study
Blood transfusion and previous stroke history are two independent risk factors of venous thromboembolism (VTE) in stroke patients. Whether the potential interaction of transfusion history and previous stroke h...
Source: Thrombosis Journal - April 17, 2023 Category: Hematology Authors: Changqing Sun, Rongrong Wang, Lianke Wang, Panpan Wang, Ying Qin, Qianyu Zhou, Yuanli Guo, Mingyang Zhao, Wenqian He, Bo Hu, Zihui Yao, Peijia Zhang, Tiantian Wu, Yu Wang and Qiang Zhang Tags: Research Source Type: research
Niemann-Pick C1 protein regulates platelet membrane-associated Ca < sup > 2+ < /sup > signalling in thrombo-occlusive diseases in mice
CONCLUSIONS: Our findings highlight that NPC1 regulates membrane-associated and SERCA3-dependent Ca2+ mobilisation during platelet activation and that MK/platelet-specific ablation of Npc1 protects against experimental models of arterial thrombosis and myocardial or cerebral ischemia/reperfusion injury.PMID:37054918 | DOI:10.1016/j.jtha.2023.03.038
Source: Thrombosis and Haemostasis - April 13, 2023 Category: Hematology Authors: Mailin-Christin Manke Anna Roslan Britta Walker Patrick M ünzer Ferdinand Kollotzek Bing Peng Stine Mencl Cristina Coman Rebecca D Szepanowski Harald Schulze Andrew P Lieberman Florian Lang Meinrad Gawaz Christoph Kleinschnitz Robert Lukowski Robert Ahre Source Type: research
Prediction of blood pressure variability during thrombectomy using supervised machine learning and outcomes of patients with ischemic stroke from large vessel occlusion
AbstractMechanical thrombectomy (MT) is the standard of care for patients with acute ischemic stroke from large vessel occlusion (AIS-LVO). The association of blood pressure variability (BPV) during MT and outcomes are unknown. We leveraged a supervised machine learning algorithm to predict patient characteristics that are associated with BPV indices. We performed a retrospective review of our comprehensive stroke center ’s registry of all adult patients undergoing MT between 01/01/2016 and 12/31/2019. The primary outcome was poor functional independence, defined as 90-day modified Rankin Scale (mRS) ≥ 3. We used p...
Source: Journal of Thrombosis and Thrombolysis - April 12, 2023 Category: Hematology Source Type: research
