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Mechanical behavior of rf-treated thrombus in mechanical thrombectomy
Stroke is the second leading cause of death with 6.7 million deaths per year [1]. Among all stroke cases, ischemic stroke accounts for 87% [2]. Ischemic stroke occurs when a thrombus or an embolus occludes a cerebral vessel, interrupting the blood flow.
Source: Medical Engineering and Physics - July 5, 2017 Category: Biomedical Engineering Authors: Chi Hang Chon, Zhen Qin, John CK Kwok, David CC Lam Source Type: research

Magnetic inductive phase shift: a new method to differentiate hemorrhagic stroke from ischemic stroke on rabbit
The major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke. Currently, computed tomography and magnetic resonance imagin...
Source: BioMedical Engineering OnLine - May 30, 2017 Category: Biomedical Engineering Authors: Qingguang Yan, Gui Jin, Ke Ma, Mingxin Qin, Wei Zhuang and Jian Sun Source Type: research

A Computational Framework for Personalized Blood Flow Analysis in the Human Left Atrium.
In this study, our aim was to develop a clinically feasible methodology to perform personalized blood flow analysis within the heart. We propose an alternative computational approach to perform personalized blood flow analysis by providing the three-dimensional LA endocardial surface motion estimated from patient-specific cardiac CT images. In two patients (case 1 and 2), a four-dimensional displacement vector field was estimated using nonrigid registration. The LA blood outflow across the mitral valve (MV) was calculated from the LV volume, and the flow field within the LA was derived from the incompressible Navier-Stokes...
Source: Annals of Biomedical Engineering - October 31, 2016 Category: Biomedical Engineering Authors: Otani T, Al-Issa A, Pourmorteza A, McVeigh ER, Wada S, Ashikaga H Tags: Ann Biomed Eng Source Type: research

Effective management of patients with acute ischemic stroke based on lean production on thrombolytic flow optimization
In this study, we aimed to determine whether applying lean principles to flow optimization could hasten the initiation of thrombolysis. A multidisciplinary team (Stroke Team) was organized to implement an ongoing, continuous loop of lean production that contained the following steps: decomposition, recognition, intervention, reengineering and assessment. The door-to-needle time (DNT) and the percentage of patients with DNT ≤ 60 min before and after the adoption of lean principles were used to evaluate the efficiency of our flow optimization. Thirteen patients with AIS in the pre-lean period and 43 patients with AIS in...
Source: Australasian Physical and Engineering Sciences in Medicine - April 18, 2016 Category: Biomedical Engineering Source Type: research

A Computational Framework for Personalized Blood Flow Analysis in the Human Left Atrium.
In this study, our aim was to develop a clinically feasible methodology to perform personalized blood flow analysis within the heart. We propose an alternative computational approach to perform personalized blood flow analysis by providing the three-dimensional LA endocardial surface motion estimated from patient-specific cardiac CT images. In two patients (case 1 and 2), a four-dimensional displacement vector field was estimated using nonrigid registration. The LA blood outflow across the mitral valve (MV) was calculated from the LV volume, and the flow field within the LA was derived from the incompressible Navier-Stokes...
Source: Annals of Biomedical Engineering - March 11, 2016 Category: Biomedical Engineering Authors: Otani T, Al-Issa A, Pourmorteza A, McVeigh ER, Wada S, Ashikaga H Tags: Ann Biomed Eng Source Type: research

Microfluidic emulation of mechanical circulatory support device shear-mediated platelet activation.
Abstract Thrombosis of ventricular assist devices (VADs) compromises their performance, with associated risks of systemic embolization, stroke, pump stop and possible death. Anti-thrombotic (AT) drugs, utilized to limit thrombosis, are largely dosed empirically, with limited testing of their efficacy. Further, such testing, if performed, typically examines efficacy under static conditions, which is not reflective of actual shear-mediated flow. Here we adopted our previously developed Device Thrombogenicity Emulation methodology to design microfluidic platforms able to emulate representative shear stress profiles o...
Source: Biomedical Microdevices - November 21, 2015 Category: Biomedical Engineering Authors: Dimasi A, Rasponi M, Sheriff J, Chiu WC, Bluestein D, Tran PL, Slepian MJ, Redaelli A Tags: Biomed Microdevices Source Type: research

Microwave-Based Stroke Diagnosis Making Global Prehospital Thrombolytic Treatment Possible
Here, we present two different brain diagnostic devices based on microwave technology and the associated two first proof-of-principle measurements that show that the systems can differentiate hemorrhagic from ischemic stroke in acute stroke patients, as well as differentiate hemorrhagic patients from healthy volunteers. The system was based on microwave scattering measurements with an antenna system worn on the head. Measurement data were analyzed with a machine-learning algorithm that is based on training using data from patients with a known condition. Computer tomography images were used as reference. The detection meth...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

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