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The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke
Conclusion: Direct inhibition of smooth muscle myosin by AmBleb in pre-capillary SMCs significantly contribute to the improvement of cerebral blood reperfusion and brain functions suggesting that smooth muscle myosin inhibition may have promising potential in stroke therapies as a follow-up treatment of physical or chemical removal of the occluding thrombus.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: M á t é P é nzes, Demeter T ú r ó s, Domokos M á th é , Kriszti á n Szigeti, Nikolett Heged ű s, Anna Á gnes Rauscher, P é ter T ó th, Ivan Ivic, Parasuraman Padmanabhan, Gabriella P á l, Á rp á d Dobolyi, M á t é Gyimesi, Andr á s M � Tags: Research Paper Source Type: research

Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice
Conclusion: We thus provide the proof of concept that in a mouse model of thromboembolic stroke with an intact skull, early ultrafast ultrasound can be indicative of responses to treatment and cerebral tissue fates following stroke. It brings new tools to study ischemic stroke in preclinical models and is the first step prior translation to the clinical settings.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Vincent Hingot, Camille Brodin, Florent Lebrun, Baptiste Heiles, Audrey Chagnot, Merv é Yetim, Maxime Gauberti, Cyrille Orset, Mickael Tanter, Olivier Couture, Thomas Deffieux, Denis Vivien Tags: Research Paper Source Type: research

PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2- 18 FFluoro- d -Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke
ConclusionsAccumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Source: Molecular Imaging and Biology - June 15, 2020 Category: Molecular Biology Source Type: research