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Specialty: Molecular Biology
Condition: Thrombosis

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Total 35 results found since Jan 2013.

The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular Medicine - July 3, 2023 Category: Molecular Biology Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
Int J Mol Sci. 2023 Feb 7;24(4):3326. doi: 10.3390/ijms24043326.ABSTRACTAtrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a role in the pathogenesis of AF and its maintenance. We aimed to evaluate a range of inflammatory markers as potentially involved in the pathophysiology of individuals with nonvalvular AF (NVAF). A total of 105 subjects were enrolled and divided into two groups: patients with NVAF (n = 55, mean age 72 ± 8 years) and ...
Source: Molecular Medicine - February 25, 2023 Category: Molecular Biology Authors: Gabriela Lopes Martins Rita Carolina Figueiredo Duarte Érica Leandro Marciano Vieira Nat ália Pessoa Rocha Est êvão Lanna Figueiredo Francisco Rezende Silveira Jos é Raymundo Sollero Caiaffa Rodrigo Pinheiro Lanna Maria das Gra ças Carvalho Andr ás Source Type: research

A Cost-Effectiveness Analysis of Biomarkers for Risk Prediction in Atrial Fibrillation
ConclusionPM compared to SOC is economically dominant and is projected to generate cost savings.
Source: Molecular Diagnosis and Therapy - January 31, 2023 Category: Molecular Biology Source Type: research

Therapeutic Use and Chronic Abuse of CNS Stimulants and Anabolic Drugs
Curr Issues Mol Biol. 2022 Oct 15;44(10):4902-4920. doi: 10.3390/cimb44100333.ABSTRACTThe available evidence suggests that affective disorders, such as depression and anxiety, increase risk for accelerated cognitive decline and late-life dementia in aging individuals. Behavioral neuropsychology studies also showed that cognitive decline is a central feature of aging impacting the quality of life. Motor deficits are common after traumatic brain injuries and stroke, affect subjective well-being, and are linked with reduced quality of life. Currently, restorative therapies that target the brain directly to restore cognitive a...
Source: Current Issues in Molecular Biology - October 26, 2022 Category: Molecular Biology Authors: Daniela Coli ță Cezar-Ivan Coli ță Dirk M Hermann Eugen Coli ță Thorsten R Doeppner Ion Udristoiu Aurel Popa-Wagner Source Type: research