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Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Conclusions The prognosis of patients with acute ischemic stroke and active cancer varied considerably depending on stroke mechanism, distant metastasis, and coagulation abnormalities. The present study confirmed that coagulation abnormalities were crucial in determining the prognosis of such patients.PMID:37489755 | DOI:10.1161/JAHA.123.029618
Source: Atherosclerosis - July 25, 2023 Category: Cardiology Authors: Yasufumi Gon Manabu Sakaguchi Hiroshi Yamagami Soichiro Abe Hiroyuki Hashimoto Nobuyuki Ohara Daisuke Takahashi Yuko Abe Tsutomu Takahashi Takaya Kitano Shuhei Okazaki Kenichi Todo Tsutomu Sasaki Satoshi Hattori Hideki Mochizuki SCAN Study Investigators Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research