• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Recombinant tissue-type plasminogen activator (rt-PA) effectively restores neurological function and improves prognosis in acute ischemic stroke
CONCLUSION: Compared with conventional pharmacological regimens, additional rt-PA intravenous thrombolytic therapy improves the clinical outcome of patients with acute ischemic stroke, promotes neurological recovery, and enhances patient prognosis without increasing the risk of patient-related adverse events.PMID:37303683 | PMC:PMC10251022
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Shouyun Zhang Dezhen Wang Lin Li Source Type: research

Decreased Lymphocyte-to-Monocyte Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Treated with Thrombolysis.
CONCLUSIONS A lower LMR value is an independent predictor of poor prognosis of AIS treated with thrombolytic therapy. PMID: 29220346 [PubMed - in process]
Source: Medical Science Monitor - December 9, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Impact of medication adherence on risk of ischemic stroke, major bleeding, and deep vein thrombosis in atrial fibrillation patients using novel oral anticoagulants.
CONCLUSION: Adherence to NOACs for both 6 months and continued prolong use (up to 12-months) was associated with a reduction in IS and DVTPE risk, but did not substantially increase risk of MB. Further studies on newer, individual NOACs and older population are warranted. PMID: 29334815 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 18, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Potential molecular targets of peroxynitrite in mediating blood-brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment.
Authors: Chen H, Chen X, Luo Y, Shen J Abstract Tissue plasminogen activator (t-PA) remains to be the only FDA-approved drug for ischaemic stroke, but it has a restrictive therapeutic window with 4.5 hours. Beyond the golden time window, thrombolytic treatment carries the risk of haemorrhagic transformation (HT). The blood-brain barrier (BBB) disruption is a critical step in the t-PA-mediated HT. Although large efforts are made to explore the mechanisms of the BBB disruption and HT, the underlying mechanisms are largely unknown. Thrombolytic treatment for recanalization could produce reactive oxygen species (ROS)...
Source: Free Radical Research - November 25, 2018 Category: Research Tags: Free Radic Res Source Type: research

Effect of pre-hospital early intervention combined with an in-hospital emergency model in the emergency care of patients with acute stroke
CONCLUSION: Pre-hospital early intervention combined with in-hospital emergency model in the first aid of patients with acute stroke can effectively improve the success rate of rescue, shorten the duration of rescue and length of hospital stay, reduce the incidence of complications, increase nursing satisfaction, and improve limb motor function and ADL.PMID:35173885 | PMC:PMC8829593
Source: American Journal of Translational Research - February 17, 2022 Category: Research Authors: Yanxia Wu Yahui Yang Xiaoling Guo Dandan Guo Yanli Lu Guang Li Fengqing Gao Jingwei Wang Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20