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Condition: Thrombosis
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Total 128 results found since Jan 2013.

Non-vitamin K antagonist oral anticoagulants (NOACs) for the management of venous thromboembolism
Learning objectives Understand the importance of venous thrombosis in cardiovascular medicine. Appreciate the mode of action of different oral anticoagulants. Recall the uses, risks and benefits of each non-vitamin K antagonist oral anticoagulants. Introduction Thrombosis is the common pathophysiology responsible for ischaemic heart disease, ischaemic stroke and venous thromboembolism (VTE), and a major contributor to the global disease burden.1 This effect is markedly more pronounced by considering the view that cancer is also a thrombotic disease.2 3 Cardiovascular disease (CVD, manifesting as acute coronary syndromes, m...
Source: Heart - June 5, 2016 Category: Cardiology Authors: Blann, A. D., Lip, G. Y. H. Tags: Education in Heart, Drugs: cardiovascular system, Acute coronary syndromes, Venous thromboembolism, Epidemiology Source Type: research

Percutaneous isolation of left atrial appendage thrombus
Publication date: Available online 16 June 2017 Source:Journal of Cardiology Cases Author(s): Oh-Hyun Lee, Jae-Sun Uhm, Jung-Sun Kim, In-Jeong Cho, Geu-Ru Hong, Hui-Nam Pak, Yangsoo Jang Most physicians regard left atrial appendage (LAA) thrombus as a contraindication for LAA occlusion due to risk of distal embolization which is a serious complication. Here we report a case of successfully implanted Amplazter cardiac plug without complication in elderly patients having LAA thrombus with recurrent embolic events despite oral anticoagulants for prevention of thromboembolic events. <Learning objective: LAA thrombus is...
Source: Journal of Cardiology Cases - June 16, 2017 Category: Cardiology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Late-Breaking Phase 2 Data for Investigational Oral Factor XIa Inhibitor Milvexian Suggest Favorable Antithrombotic Profile Across a Wide Range of Doses
This study establishes proof-of-principle for milvexian as a differentiated antithrombotic agent,” said Jeffrey Weitz, M.D., Professor of Medicine & Biochemistry and Biomedical Sciences at McMaster University and Executive Director of the Thrombosis and Atherosclerosis Research Institute.[i] “Furthermore, the consistently low rates of bleeding across a 16-fold range of milvexian doses suggest that it has a wide therapeutic window, which opens the opportunity to explore milvexian across a broad range of patients including those for whom factor Xa inhibitors are underutilized or not indicated.” The trial met both o...
Source: Johnson and Johnson - November 15, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Thrombosis origin identification of cardioembolism and large artery atherosclerosis by distinct metabolites
CONCLUSIONS: Six metabolites as potential predictors for distinguishing between cerebral thrombi of CE and LAA origin were identified. The results are useful for understanding the pathogenesis and for secondary stroke prevention.PMID:35654581 | DOI:10.1136/neurintsurg-2022-019047
Source: Atherosclerosis - June 2, 2022 Category: Cardiology Authors: Wei Li Xuesong Bai Jiheng Hao Xin Xu Feng Lin Qunlong Jiang Chunguang Ding Gaolei Dai Fangda Peng Meng Zhang Yao Feng Jiyue Wang Xianyang Chen Teng Xue Xiaofan Guo Zhaolin Fu Wen-Huo Chen Liyong Zhang Chaodong Wang Liqun Jiao Source Type: research

Yaz Settlement News Provided by the Skikos Law Firm, New Claims Still...
Yaz lawsuits continue to result in settlements for victims of blood clots and related injuries such as stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE). Readers can learn more at...(PRWeb May 08, 2013)Read the full story at http://www.prweb.com/releases/2013/5/prweb10707101.htm
Source: PRWeb: Medical Pharmaceuticals - May 11, 2013 Category: Pharmaceuticals Source Type: news

157 E-Books New to JEFFLINE
Scott Library added these 157 e-books to the growing collection in May and June: Accurate Results in the Clinical Laboratory Adult Emergency Medicine Adult-Gerontology and Family Nurse Practitioner Certification Examination (4th ed.) Advanced Assessment: Interpreting Findings and Formulating Differential Diagnoses (2nd ed.) Advancing Your Career: Concepts of Professional Nursing (5th ed.) Arrhythmia Essentials Atlas of Advanced Operative Surgery Atlas of Clinical Neurology (3rd ed.) Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches Atlas of Human Infectious Diseases Atlas of No...
Source: What's New on JEFFLINE - June 25, 2013 Category: Databases & Libraries Authors: Gary Kaplan Tags: All News Clinicians Researchers Students Teaching Faculty Source Type: news

Yaz Settlements Reach $1.4 Billion Reports the Skikos Law Firm, New...
Women who allegedly suffered blood clot injuries such as stroke, pulmonary embolism (PE), and deep vein thrombosis (DVT) continue to receive Yaz lawsuit settlements in 2013. Readers can learn more at...(PRWeb July 31, 2013)Read the full story at http://www.prweb.com/releases/2013/7/prweb10982921.htm
Source: PRWeb: Medical Pharmaceuticals - July 31, 2013 Category: Pharmaceuticals Source Type: news

Significance of the learning curve in left atrial appendage occlusion with two different devices
Conclusions: Complications associated with LAA occlusion cluster early in the periprocedural period and significantly decrease in frequency with operator experience. Initial experience gained with one of device may improve outcome with use of alternative LAA occlusion devices. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - October 6, 2013 Category: Cardiovascular & Thoracic Surgery Authors: I. Cruz‐Gonzalez, A Perez‐Rivera, R Lopez‐Jimenez, J Rodriguez‐Collado, J Martín‐Moreiras, M Cascon, A. Arribas, J.C. Gomez, Andrew O Maree, C Martin‐Luengo Tags: Original Studies Source Type: research

Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research

Rare platelet GPCR variants: what can we learn?
Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side effects. In order to optimize the use of existing anti‐platelet drugs and to develop new therapies, more detailed knowledge is required relating to the molecular mechanisms that regulate GPCR and therefore platelet fu...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: S P Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Board #247 - Program Innovation Engaging Learners in an Annual Nursing Staff Competency Blitz through Video Simulations (Submission #9201).
Conclusion: Over 1,500 staff nurses and 500 assistive personnel participated in the nursing competency blitz over a two-week time frame. Overall, the nursing staff was very positive about the format and use of simulation to ensure competency. Approximately 48% of staff rated the use of video simulations for Blitz as being extremely effective (e.g. 10 on a 1-10 scale), with over 86% rating the effectiveness at an 8 or higher. Time to complete the competencies was much less (715 total hours) than expected (1400 hours) based on previous years. Improvements in competency were noted for both staff nurses (improvement in scores ...
Source: Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare - December 1, 2014 Category: Medical Equipment Tags: Abstracts: 2ND PLACE AWARD WINNER: PDF Only Source Type: research

What Are Common Inherited Thrombophilias?
Discussion Thrombophilia is the increased risk of thromboembolic disease due to a disorder. Thrombophilia can be inherited or acquired (such as antiphospholipid syndrome). The risk of thromboembolic events is much lower in children than adults. At-risk patients should avoid: Dehydration Sitting for prolonged time periods during travel Obesity Smoking Estrogen containing oral contraceptives Common inherited thrombophilias include: Prothrombin (Factor II mutation) Second most common Genetics: 1-2% prevalence is variable depending on location and ethnic background. Cause: Abnormal point mutation of the prothrombin gene t...
Source: PediatricEducation.org - May 25, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news