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Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
ConclusionsSARS-CoV-2 can lead to neurological complications, such as cerebrovascular manifestations, motor movement complications, and cognitive decline. COVID-19 infection can result in cerebrovascular symptoms and diseases, such as strokes and thrombosis. The virus can affect the neural system, disrupt cognitive function and cause neurological disorders. To combat the epidemic, it is crucial to repurpose drugs currently in use quickly and develop novel therapeutics.
Source: European Journal of Medical Research - August 30, 2023 Category: Research Source Type: research

Mechanisms of COVID-19-induced cerebellitis
Curr Med Res Opin. 2022 Oct 28:1-25. doi: 10.1080/03007995.2022.2141963. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by SARS-CoV2 has raised several important health concerns, not least increased mortality and morbidity. SARS-CoV2 can infect the central nervous system via hematogenous or transneuronal routes, acting through different receptors including ACE2, DPP4 and neuropilin 1- and cause several issues, include the focus here, cerebellitis. The cerebellum is an essential part of the CNS located adjacent to the brainstem with a complex micro and macroscopic structure. The cerebellum plays several physiolo...
Source: Current Medical Research and Opinion - October 28, 2022 Category: Research Authors: Mohammad Banazadeh Sepehr Olangian-Tehrani Melika Sharifi Mohammadreza Malek-Ahmadi Farhad Nikzad Nooria Doozandeh-Nargesi Alireza Mohammadi Gary J Stephens Mohammad Shabani Source Type: research

Impact of the COVID-19 pandemic on England's national prescriptions of oral vitamin K antagonist (VKA) and direct-acting oral anticoagulants (DOACs): An interrupted time series analysis (January 2019 - February 2021)
Conclusion: The overall oral anticoagulants use in this period was lower than expected, indicating a medical needs gap, possibly due to adherence issues. The potential clinical and logistical consequences warrant further study to identify contributing factors and mitigate avoidable risks.PMID:35582854 | DOI:10.1080/03007995.2022.2078100
Source: Current Medical Research and Opinion - May 18, 2022 Category: Research Authors: Sajidah Alkhameys Ravina Barrett Source Type: research

Interpretation of myocardial injury subtypes in COVID-19 disease per fourth version of universal definition of myocardial infarction
Conclusions: Objective description of myocardial injury according to the 4th UDMI in current COVID-19 pandemic is crucial in order to discriminate patients with acute myocardial infarction and acute, chronic or incident myocardial injury.PMID:33998352 | DOI:10.1080/1354750X.2021.1921031
Source: Biomarkers - May 17, 2021 Category: Research Authors: Christian Salbach Matthias Mueller-Hennessen Moritz Biener Kiril Stoyanov Michael Preusch Lars Kihm Uta Merle Paul Schnitzler Hugo A Katus Evangelos Giannitsis Source Type: research

Comparison of Clinical Outcomes in Patients with ST Elevation Myocardial Infarction with Percutaneous Coronary Intervention and the Use of a Telemedicine App Before and After the COVID-19 Pandemic at a Center in Beijing, China, from August 2019 to March 2020.
CONCLUSIONS Telemedicine reduced the delay time of STEMI patients during the COVID-19 pandemic. The difference in short-term adverse clinical outcomes was not statistically significant between patients who used the app and those who did not. PMID: 32938901 [PubMed - in process]
Source: Medical Science Monitor - September 18, 2020 Category: Research Tags: Med Sci Monit Source Type: research