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Condition: Thrombosis
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Total 297 results found since Jan 2013.

Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study
CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.PMID:35830430 | DOI:10.1371/journal.pone.0268481
Source: Atherosclerosis - July 13, 2022 Category: Cardiology Authors: Yuichiro Ohya Ryu Matsuo Noriko Sato Fumi Irie Kuniyuki Nakamura Yoshinobu Wakisaka Tetsuro Ago Masahiro Kamouchi Takanari Kitazono Investigators for Fukuoka Stroke Registry Source Type: research

Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats
Conclusion: The current study shows for the first time that in hypertension the number of TF-positive megakaryocytes increases thus releasing in the circulation more platelets carrying a functionally active TF. AngII stimulates platelets to express TF.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Intravenous Thrombolysis in Posterior Circulation Stroke
Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset. Introduction History of Intravenous Thrombolysis—The Most Relevant Studies Intravenous...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Japanese and Non-Japanese Patients with Transient Ischemic Attack or Minor Stroke: A Five-Year Risk Analysis of Stroke and Vascular Events.
CONCLUSIONS: Recurrent stroke and intracranial hemorrhage were determined to be more prevalent at 5 years after TIA or minor stroke in Japanese patients than in non-Japanese patients. Strategies to mitigate the long-term risks of stroke, aside from adherence to current guidelines, should take Japanese-patient-specific residual risks into account. PMID: 32938836 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - September 19, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Subtype-Dependent Reporting of Stroke With SGLT2 Inhibitors: Implications From a Japanese Pharmacovigilance Study.
Abstract Volume depletion as an adverse events (AE) caused by sodium-glucose cotransporter-2 inhibitors (SGLT2i) because of their diuretic effect may raise the concern about the risk of lacunar stroke; however, an earlier meta-analysis reported no significant increase in the incidence of stroke without clearly distinguishing stroke subtypes. Here, aiming to investigate subtype-wise reporting of stroke potentially related to SGLT2i treatment, we conducted a disproportionality analysis using the Japanese Adverse Drug Event Report database, which contains approximately 500 000 cases recorded between April 2004 and M...
Source: The Journal of Clinical Pharmacology - December 1, 2019 Category: Drugs & Pharmacology Authors: Sato K, Mano T, Iwata A, Toda T Tags: J Clin Pharmacol Source Type: research

The Association between Glomerular Filtration Rate Estimated on Admission and Acute Stroke Outcome: The Shiga Stroke Registry.
CONCLUSIONS: Our study has ascertained that in acute stroke, particularly ischemic stroke, low eGFR was significantly associated with in-hospital death and at-discharge death/disability. Additionally, high eGFR was found to be associated with at-discharge death/disability. PMID: 29353826 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - January 24, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study
CONCLUSIONS: In the Japanese community, the risk of recurrent stroke decreased mainly from the 1960s to 1990s, but there was no apparent decrease in recent years.PMID:35185108 | DOI:10.5551/jat.63344
Source: Journal of Atherosclerosis and Thrombosis - February 21, 2022 Category: Cardiology Authors: Yasuyuki Nakanishi Yoshihiko Furuta Jun Hata Tomohiro Yubi Emi Oishi Satoko Sakata Yoichiro Hirakawa Yoshinobu Wakisaka Tetsuro Ago Takanari Kitazono Toshiharu Ninomiya Source Type: research

Predictors of Survival in Patients With Ischemic Stroke and Active Cancer: A Prospective, Multicenter, Observational Study
Conclusions The prognosis of patients with acute ischemic stroke and active cancer varied considerably depending on stroke mechanism, distant metastasis, and coagulation abnormalities. The present study confirmed that coagulation abnormalities were crucial in determining the prognosis of such patients.PMID:37489755 | DOI:10.1161/JAHA.123.029618
Source: Atherosclerosis - July 25, 2023 Category: Cardiology Authors: Yasufumi Gon Manabu Sakaguchi Hiroshi Yamagami Soichiro Abe Hiroyuki Hashimoto Nobuyuki Ohara Daisuke Takahashi Yuko Abe Tsutomu Takahashi Takaya Kitano Shuhei Okazaki Kenichi Todo Tsutomu Sasaki Satoshi Hattori Hideki Mochizuki SCAN Study Investigators Source Type: research

Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-I Randomized Controlled Trial.
CONCLUSIONS: Although statistical significance was not reached, the efficacy of prasugrel was potentially different between stroke subtypes, warranting further studies. PMID: 32493881 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - June 6, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Registry Studies of Stroke in Japan
J Atheroscler Thromb. 2023 Jul 19. doi: 10.5551/jat.RV22008. Online ahead of print.ABSTRACTRecently, the Cerebrovascular and Cardiovascular Disease Control Act was enacted, for which it was necessary to establish a comprehensive and accurate nationwide database and promote rational and economical stroke countermeasures in Japan, thus serving the public interest. Among the many studies on stroke registries, the Fukuoka Stroke Registry, a regional cohort, provides highly accurate information, and the Japanese Stroke Data Bank, a nationwide cohort, is highly comprehensive. The findings of these studies have contributed to the...
Source: Journal of Atherosclerosis and Thrombosis - July 19, 2023 Category: Cardiology Authors: Ryu Matsuo Source Type: research