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Propensity Score-Matched Analysis of Lesion Patterns in Stroke Patients With Patent Foramen Ovale and Patients With Spontaneous Intracranial Artery Dissection
Conclusion: The present study suggests that lesion patterns observed from DWI of patients with PFO and SIAD might provide clues to the etiology of infarcts. Single lesions (cortical or subcortical) might be a typical feature of PFO associated strokes, while multiple lesions in one vascular territory might be a specific feature of SIAD associated strokes. Introduction Both patent foramen ovale (PFO) and spontaneous intracranial artery dissection (SIAD) are important stroke risk factors, especially in young and middle-aged adults (1–3). About 25% of patients with ischemic stroke are cryptogenic (4), and PFO is ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Long-term Risk of Complications after Percutaneous Transcatheter Closure of Patent Foramen Ovale (S51.003)
Conclusions:Approximately 1 in 6 patients who undergo percutaneous transcatheter closure of PFO after stroke or transient ischemic attack experience a serious complication or death within 5 years.Study Supported by:Dr. Gialdini is supported by the Feil Family Foundation.Dr. Navi is supported by NIH grant K23NS091395 and the Florence Gould Endowment for Discovery in Stroke.Dr. Iadecola is supported by NIH grants R37NS089323-02, R01NS034179-21, R01NS037853-19, and R01 NS073666-04.Dr. Kamel is supported by NIH grants K23NS082367 and R01NS097443 as well as the Michael Goldberg Research Fund.Disclosure: Dr. Merkler has nothing ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Gialdini, G., Yaghi, S., Okin, P., Iadecola, C., Navi, B., Kamel, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Impending paradoxical embolism: Have we lost the clot?
First demonstrated on echocardiography in 1985, impending paradoxical embolism refers to a thrombus traversing an atrial septal defect, usually a patent foramen ovale (PFO) [1]. Estimates of the prevalence of PFO range from 15% to 35% but impending paradoxical embolism is rare, with fewer than 200 cases reported in the literature [2‐4]. Most cases are associated with pulmonary emboli. Elevated pulmonary and right atrial pressures may push a thrombus through a PFO into the systemic circulation, producing paradoxical systemic embolization. The high risk of cardio‐embolic stroke makes the diagnosis an emergency. Treatment...
Source: The Clinical Respiratory Journal - October 1, 2013 Category: Respiratory Medicine Authors: Finn Ghent, Levi Bassin, Michael Keller, Gregory Cranney, David McKenzie, Peter Grant Tags: Other Source Type: research