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Gait speed and spasticity are independently associated with estimated failure load in the distal tibia after stroke: an HR-pQCT study
ConclusionThe paretic distal tibia showed more compromised vBMD, cortical area, cortical thickness, and estimated failure load than the non-paretic tibia. Gait speed and spasticity were independently associated with estimated failure load. As treatment programs focusing on these potentially modifiable stroke-related impairments are feasible to administer, future studies are needed to determine the efficacy of such intervention strategies for improving bone strength in individuals with chronic stroke.
Source: Osteoporosis International - October 12, 2021 Category: Orthopaedics Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Bone Mineral Density and Incidence of Stroke: European Prospective Investigation Into Cancer-Norfolk Population-Based Study, Systematic Review, and Meta-Analysis Clinical Sciences
Conclusions— Bone mineral density predicts total stroke risk. The evidence is stronger in women with regard to the continuous relationship.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Myint, P. K., Clark, A. B., Kwok, C. S., Loke, Y. K., Yeong, J. K.-Y., Luben, R. N., Wareham, N. J., Khaw, K.-T. Tags: Epidemiology Clinical Sciences Source Type: research