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Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril- or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims Database Analysis
CONCLUSION: In South African individuals with private health insurance, a perindopril-based antihypertensive regimen provided better clinical and cost outcomes compared with other regimens.PMID:37730949 | DOI:10.1007/s12325-023-02641-8
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Jacques R Snyman Freedom Gumedze Erika S W Jones Olufunke A Alaba Nqoba Tsabedze Alykhan Vira Ntobeko A B Ntusi Source Type: research

Participation by patients from low- and middle-income countries (LMICs) in trial evidence supporting secondary stroke prevention guideline recommendations
CONCLUSIONS: Compared to their global burden of stroke, LMICs are underrepresented in key clinical trials used in formulating a prominent global stroke prevention guideline. While current therapeutic recommendations are likely applicable to practice settings throughout the world, greater involvement of patients from LMIC settings will enhance the contextual relevance and generalizability of recommendations to these disparate populations.PMID:37028264 | DOI:10.1016/j.jns.2023.120641
Source: Atherosclerosis - April 7, 2023 Category: Cardiology Authors: Priscilla Abrafi Opare-Addo Fred Stephen Sarfo Patrick Opoku Berchie Minas Aikins Bruce Ovbiagele Source Type: research

Promise of Physiological Profiling to Prevent Stroke in People of African Ancestry: Prototyping Ghana
AbstractPurpose of ReviewWorldwide, compared to other racial/ethnic groups, individuals of African ancestry have an excessively higher burden of hypertension-related morbidities, especially stroke. Identifying modifiable biological targets that contribute to these disparities could improve global stroke outcomes. In this scoping review, we discuss how pathological perturbations in the renin –angiotensin–aldosterone pathways could be harnessed via physiological profiling for the purposes of improving blood pressure control for stroke prevention among people of African ancestry.Recent FindingsTranscontinental comparative...
Source: Current Neurology and Neuroscience Reports - October 1, 2022 Category: Neuroscience Source Type: research

Hypertension in the South African public healthcare system: a cost-of-illness and burden of disease study
Conclusion Hypertension exerts a heavy health and economic burden on South Africa. Establishing cost-effective best practice guidelines for hypertension treatment requires further research. Such research will be essential if South Africa is to make progress in its efforts to implement universal healthcare.
Source: BMJ Open - February 22, 2022 Category: General Medicine Authors: Kohli-Lynch, C. N., Erzse, A., Rayner, B., Hofman, K. J. Tags: Open access, Health economics Source Type: research

Stroke: A retrospective review of the incidence and epidemiology in a South African academic hospital emergency department
CONCLUSIONS: Stroke is an important healthcare concern for SA. Our study demonstrated a lower mean age of patients presenting with stroke compared with high- and upper middle-income countries, and a higher proportion of haemorrhagic strokes. Several modifiable risk factors such as hypertension and diabetes were identified. Data collection on a regional and national level is important to drive targeted healthcare initiatives.PMID:34949308 | DOI:10.7196/SAMJ.2021.v111i12.15682
Source: South African Medical Journal - December 24, 2021 Category: African Health Authors: S Tribelhorn F Motara C M Lewis Source Type: research

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