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Source: Frontiers in Neurology
Condition: Hemorrhagic Stroke

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Total 496 results found since Jan 2013.

Levels of adhesion molecules and clinical outcomes in patients with ischemic stroke after mechanical thrombectomy
ConclusionsThere were significant relationships between levels of adhesion molecules and a 90-day poor outcome in patients with ischemic stroke treated with MT, which was partially mediated by sICH.
Source: Frontiers in Neurology - September 29, 2022 Category: Neurology Source Type: research

The evolution of intracranial aneurysm research from 2012 to 2021: Global productivity and publication trends
ConclusionThe contribution made by different countries, institutions, journals, and authors for IA research over the past decade was demonstrated in the paper. The main topics include the choice of EVT or surgical clipping, particularly the application of flow diverter and associated complications, while themes such as the etiopathogenetic features of IA (e.g., inflammation and hemodynamics) deserve more attention.
Source: Frontiers in Neurology - September 28, 2022 Category: Neurology Source Type: research

Post-operative neutrophil-to-lymphocyte ratio and outcome after thrombectomy in acute ischemic stroke
ConclusionNLR immediately after thrombectomy is a readily available biomarker of HT and neurological outcomes in patients with AIS.
Source: Frontiers in Neurology - September 28, 2022 Category: Neurology Source Type: research

Eptifibatide use in ischemic stroke patients undergoing endovascular thrombectomy: A matched cohort analysis
ConclusionIn this single-center analysis, EPT use during EVT was associated with a significantly higher rate of PH1/PH2 grade hemorrhages, but not with differences in sICH, 24-h NIHSS, or 90-day mortality. Randomized prospective trials are needed to determine the safety and efficacy of EPT in this population.
Source: Frontiers in Neurology - September 27, 2022 Category: Neurology Source Type: research

Blood-based protein biomarkers for the diagnosis of acute stroke: A discovery-based SWATH-MS proteomic approach
ConclusionOur discovery phase study identified potential protein biomarker candidates for the diagnosis of acute stroke and highlighted significant pathways associated with different stroke subtypes. These potential biomarker candidates warrant further validation in future studies with a large cohort of stroke patients to investigate their diagnostic performance.
Source: Frontiers in Neurology - September 27, 2022 Category: Neurology Source Type: research

Continuing early mTICI 2b recanalization may improve functional outcome but is associated with a higher risk of intracranial hemorrhage
ConclusionSuccessfully improving an early mTICI 2b to mTICI 2c/3 reperfusion is possible in a substantial number of patients and might improve functional outcome. However, an increase in symptomatic intracranial hemorrhage (SICH) due to further retrieval attempts may diminish the potential functional benefit to continue early mTICI 2b. To support this finding, further investigation with more power is needed to account for the low number of events regarding SICH.
Source: Frontiers in Neurology - September 26, 2022 Category: Neurology Source Type: research

Walking speed at the acute and subacute stroke stage: A descriptive meta-analysis
Gait disorders are one of the leading patient complaints at the sub-acute stroke stage (SSS) and a main determinant of disability. Walking speed (WS) is a major vital and functional index, and the Ten-Meter Walk Test is considered the gold standard after stroke. Based on a systematic review of the literature, studies published between January 2000 and November 2021 were selected when WS was reported (ten-meter walk test for short distance and/or 6-min walking distance for long distance) within 6 months following a first ischemic and/or hemorrhagic stroke (SSS) in adults prior to receiving specific walking rehabilitation. F...
Source: Frontiers in Neurology - September 26, 2022 Category: Neurology Source Type: research

Influence of pre-stroke dependency on safety and efficacy of endovascular therapy: A systematic review and meta-analysis
ConclusionsPSD does not innately influence the EVT outcomes regarding sICH and favorable outcomes but may increase the risk of 90-day mortality. Until further evidence is available, it is reasonable to suggest EVT for patients with PSD.
Source: Frontiers in Neurology - September 21, 2022 Category: Neurology Source Type: research

Intravenous thrombolysis with 0.65 mg/kg r-tPA may be optimal for Chinese mild-to-moderate stroke
ConclusionOur study presented the first evidence that intravenous thrombolysis with 0.65 mg/kg r-tPA may be optimal for Chinese mild-to-moderate stroke.Registrationhttps://www.clinicaltrials.gov, identifier: NCT 02854592.
Source: Frontiers in Neurology - September 20, 2022 Category: Neurology Source Type: research

Impact of type of oral anticoagulants in patients with cerebral microbleeds after atrial fibrillation-related ischemic stroke or TIA: Results of the NOACISP-LONGTERM registry
ConclusionsIn AF-stroke patients treated with OAC, the presence of CMBs was associated with an unfavorable composite outcome for both VKAs and DOACs, with a higher risk for recurrent IS than for ICH. Strokes were numerically higher under VKAs and increased in the presence of CMBs.Clinical trial registrationhttp://www.clinicaltrials.gov, Unique identifier: NCT03826927.
Source: Frontiers in Neurology - September 20, 2022 Category: Neurology Source Type: research

Incidence, lethality, and post-stroke functional status in different Brazilian macro-regions: The SAMBA study (analysis of stroke in multiple Brazilian areas)
ConclusionThis study expands the knowledge of stroke epidemiology in Brazil, a middle-income country with enormous socioeconomic and cultural diversity. The discrepancy observed regarding the impact of stroke in patients from Joinville and Sobral highlights the need to improve the strategic allocation of resources to meet the health priorities in each location.
Source: Frontiers in Neurology - September 15, 2022 Category: Neurology Source Type: research

General anesthesia but not conscious sedation improves functional outcome in patients receiving endovascular thrombectomy for acute ischemic stroke: A meta-analysis of randomized clinical trials and trial sequence analysis
ConclusionPatients with acute anterior circulation ischemic stroke receiving GA were associated with a higher successful recanalization rate as well as a better 3-month neurological outcome compared to the use of CS. Further investigations are warranted to verify our findings.Systematic review registrationwww.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022342483, identifier: CRD42022342483.
Source: Frontiers in Neurology - September 14, 2022 Category: Neurology Source Type: research

Identification of magnetic resonance imaging features for the prediction of unrecognized atrial fibrillation in acute ischemic stroke
Conclusion Initial MRI at the time of stroke may be useful to predict which patients have cardioembolic stroke caused by unrecognized AF. Further studies are warranted to verify these findings and their application to high-risk patients.
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research

Dual vs. mono antiplatelet therapy for acute ischemic stroke or transient ischemic attack with evidence of large artery atherosclerosis
ConclusionIn patients with symptomatic large artery extracranial or intracranial atherosclerosis, DAPT was superior to MAPT in preventing IS recurrence without increasing bleeding risks. The optimal DAPT regimens and duration of treatment in this population need to be clarified in further studies.
Source: Frontiers in Neurology - September 12, 2022 Category: Neurology Source Type: research

A novel nomogram to predict hemorrhagic transformation in ischemic stroke patients after intravenous thrombolysis
ConclusionThis study proposes a novel and practical nomogram based on early infarct signs, NIHSS scores, uric acid, and albumin-to-globulin ratio that can well predict the probability of HT after intravenous thrombolysis in patients with ischemic stroke.
Source: Frontiers in Neurology - September 8, 2022 Category: Neurology Source Type: research