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Emerging role of miRNAs in the regulation of ferroptosis
Front Mol Biosci. 2023 Feb 15;10:1115996. doi: 10.3389/fmolb.2023.1115996. eCollection 2023.ABSTRACTFerroptosis is a kind of cell death which has distinctive features differentiating it from autophagy, necrosis and apoptosis. This iron-dependent form of cell death is described by an increase in lipid reactive oxygen species, shrinkage of mitochondria and decrease in mitochondrial cristae. Ferroptosis is involved in the initiation and progression of many diseases and is regarded as a hotspot of investigations on treatment of disorders. Recent studies have shown that microRNAs partake in the regulation of ferroptosis. The im...
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Reza Mahmoudi-Lamouki Sepideh Kadkhoda Bashdar Mahmud Hussen Soudeh Ghafouri-Fard Source Type: research

MRI for all: Cheap portable scanners aim to revolutionize medical imaging
.news-article__hero--featured .parallax__element{ object-position: 47% 50%; -o-object-position: 47% 50%; } The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing. The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research

Role of lipocalin 2 in stroke
Neurobiol Dis. 2023 Feb 16:106044. doi: 10.1016/j.nbd.2023.106044. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression i...
Source: Neurobiology of Disease - February 22, 2023 Category: Neurology Authors: Ruo-Yu Zhao Peng-Ju Wei Xin Sun Dian-Hui Zhang Qian-Yan He Jie Liu Jun-Lei Chang Yi Yang Zhen-Ni Guo Source Type: research

Regulation of the p53 ‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
Exp Ther Med. 2023 Jan 26;25(3):113. doi: 10.3892/etm.2023.11812. eCollection 2023 Mar.ABSTRACTStroke is one of the most threatening diseases worldwide, particularly in countries with larger populations; it is associated with high morbidity, mortality and disability rates. As a result, extensive research efforts are being made to address these issues. Stroke can include either hemorrhagic stroke (blood vessel ruptures) or ischemic stroke (blockage of an artery). Whilst the incidence of stroke is higher in the elderly population (≥65), it is also increasing in the younger population. Ischemic stroke accounts for ~85% of a...
Source: Experimental and Therapeutic Medicine - February 16, 2023 Category: General Medicine Authors: Shuangli Xu Xuewei Li Yanqiang Wang Source Type: research

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
In conclusion, the mutual regulation of autophagy and inflammation in ICH is worth exploring. The control of inflammation by autophagy will hopefully prove to be an essential treatment target for ICH.PMID:36726453 | PMC:PMC9884704 | DOI:10.3389/fncel.2022.1036313
Source: Cancer Control - February 2, 2023 Category: Cancer & Oncology Authors: Kaijing Fu Weilin Xu Cameron Lenahan Yong Mo Jing Wen Teng Deng Qianrong Huang Fangzhou Guo Ligen Mo Jun Yan Source Type: research

Deferoxamine Prevents Post-Stroke Memory Impairment in Female Diabetic Rats: Potential Links to Hemorrhagic Transformation and Ferroptosis
Am J Physiol Heart Circ Physiol. 2022 Dec 23. doi: 10.1152/ajpheart.00490.2022. Online ahead of print.ABSTRACTDiabetes increases the risk of post-stroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stroke is associated with vasoregression and cognitive decline in male diabetic rats. Iron chelator deferoxamine (DFX) prevents vasoregression and improves outcomes. While diabetic female rats develop greater HT, its impact on post-stroke cerebrovascularization and cognitive outcomes remained unknown. We hypothesized that diabetes mediates pathological neovascularization, and DFX attenuates post-str...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 23, 2022 Category: Physiology Authors: Weiguo Li Yasir Abdul Raghavendar Chandran Sarah Jamil Rebecca A Ward Mohammed Abdelsaid Guangkuo Dong Susan C Fagan Adviye Ergul Source Type: research

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