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Trends in Intensive Care Admissions and Outcomes of Stroke Patients Over 10 Years in Brazil: Impact of the COVID-19 Pandemic
Chest. 2022 Nov 5:S0012-3692(22)04049-1. doi: 10.1016/j.chest.2022.10.033. Online ahead of print.ABSTRACTBACKGROUND: The coronavirus 2019 (COVID-19) pandemic affected stroke care worldwide. Data from low- and middle-income countries is limited.RESEARCH QUESTION: What was the impact of the pandemic in intensive care admissions and outcomes of patients with stroke, in comparison to trends over the last ten years?STUDY DESIGN AND METHODS: Retrospective cohort study including prospectively collected data from 165 ICUs in Brazil between 2011 and 2020. We analyzed clinical characteristics and mortality over a period of 10 years ...
Source: Chest - November 8, 2022 Category: Respiratory Medicine Authors: Pedro Kurtz Leonardo S L Bastos Fernando G Zampieri Gabriel R de Freitas Fernando A Bozza Marcio Soares Jorge I F Salluh Source Type: research

A Polymorphism in Toll-like Receptor 2 Gene Is Associated with Occurrence of Bacterial Infections in Sickle Cell Disease Patients
Discussion: In SCD pts, TLR-2 rs4696480 TA genotype might be protective against bacterial infections, whereas TT genotype might increase risk of such infections. Previous reports demonstrated higher secretion of inflammatory factors in cells from AA individuals, lower occurrence and severity of immune diseases in T carriers. TA genotype might stand between deleterious effects of over inflammatory response (AA genotype) and under response (TT genotype) to infectious agents.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Tozatto-Maio, K., Girot, R., Ly, I. D., Rocha, V., Pinto, A. C. S., Diagne, I., Benzerara, Y., Dinardo, C. L., Kashima, S., Araujo, I. L., Kenzey, C., Fonseca, G. H. H., Rodrigues, E., Volt, F., Jarduli, L. R., Ruggeri, A., Mariaselvam, C. M., Gualandro, Tags: 113. Hemoglobinopathies, Excluding Thalassemia-Basic and Translational Science: Poster III Source Type: research

New sequence types of Acinetobacter baumannii in two emergency hospitals in the Central-West region of Brazil
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients.
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Hydrocephalous as a Complication of Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage
JLSM, male, 71 years old, admitted into a private hospital in the city of Joinville, Brazil, complaining of persistent and severe headache. The patient reported onset of the condition three days before, after sexual activity, associated with nausea, vomiting and dizziness. He has a medical history of epilepsy, under regular use of Phenobarbital. The physical examination evidenced slight nuchal rigidity. Cranial computed tomography (CT) showed subarachnoid hemorrhage (SAH) in cisterns around the brainstem (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - October 20, 2020 Category: Neurology Authors: Guilherme Zini Reis, Fernanda Subtil de Moraes Machado, Wladimir Kummer de Paula, Fl ávio Diniz Ribas, Felipe Ibiapina dos Reis Tags: Case Report Source Type: research