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164 Dementia, a Familial Affair
ConclusionThis case highlights the importance of genetics shaping phenotypes and that consideration should always be given to a full relevant family history.  It also shows a rare case of rapidly progressive dementia confirmed due to CJD with a likely underlying familial predisposition.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Crossed cerebellar diaschisis in Creutzfeldt-Jakob disease evaluated through single photon emission computed tomography
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of human prion disease; it is characterized as a transmissible spongiform encephalopathy. Previously, only two case reports have discussed crossed cerebellar diaschisis (CCD) and sCJD. Herein, we detected CCD in five patients with sCJD and four patients with genetic CJD through SPECT. The combined data of the nine patients further supported CCD when analyzed by 3D-SSP. CCD can occur in several disorders, including, stroke, epilepsy, and encephalitis.
Source: Journal of the Neurological Sciences - September 24, 2018 Category: Neurology Authors: Kenya Nishioka, Michimasa Suzuki, Katsuya Satoh, Nobutaka Hattori Tags: Letter to the Editor Source Type: research

Seizures after craniectomy: an under-recognised complication?
Decompressive craniectomy for ischaemic stroke is being increasingly used, at least in the USA.1 This has likely been stimulated by three randomised clinical trials reporting improved survival in appropriately selected patients.2 As the number of patients so treated, and surviving, increases, a better picture of the complications and outcomes is emerging, with recognition of the relatively high risk of infection when the cranium is reconstructed after the craniectomy, as well as the occurrence of postoperative extra-axial haemorrhages and delayed hydrocephalus.3 Creutzfeldt et al4 highlight another surprisingly frequent se...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Macdonald, R. L. Tags: Epilepsy and seizures, Hydrocephalus, Neurooncology, Stroke, CNS cancer, Drugs: psychiatry, Drugs: musculoskeletal and joint diseases, Surgical oncology Editorial commentaries Source Type: research

Seizures after decompressive hemicraniectomy for ischaemic stroke
Conclusions In this case series, patients were at high risk of developing seizures after malignant MCA stroke with DHC, especially after cranioplasty. Assuming these findings are replicated, means should be sought to reduce the occurrence of this complication.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Creutzfeldt, C. J., Tirschwell, D. L., Kim, L. J., Schubert, G. B., Longstreth, W. T., Becker, K. J. Tags: Epilepsy and seizures, Stroke Cerebrovascular disease Source Type: research

Voltage Gated Calcium Channels Antibody-Associated Autoimmune Encephalitis (P5.228)
ConclusionThis case demonstrates a correlation between a high titer of VGCC antibodies and autoimmune encephalitis. Our patient's initial improvement with steroids and plasma exchange in the face of a negative CT and PET suggests a primary autoimmune process rather than a paraneoplastic etiology, though we admit that it is premature to rule out remission and we will continue to follow herDisclosure: Dr. Alwaki has nothing to disclose. Dr. Lugo has nothing to disclose. Dr. Goshgarian has nothing to disclose. Dr. Ahmad has nothing to disclose. Dr. Hefzy has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alwaki, A., Lugo, A., Goshgarian, C., Ahmad, O., Hefzy, H., Mitsias, P. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Creutzfeldt-Jakob Disease and Subacute Encephalopathies Source Type: research

Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction
Antiphospholipid syndrome (APS) is a rare autoimmune coagulopathy with various systemic and neurologic symptoms. Ischemic stroke and TIA are common neurologic manifestations of APS, while migraine, epilepsy, chorea, and multiple sclerosis–like syndromes have also been reported.1,2 Dementia is an unusual manifestation of APS, and the presentation of APS with corticobasal syndrome (CBS) has rarely been reported.3,4 CBS is a progressive neurologic syndrome characterized by asymmetric cortical dysfunction, such as apraxia, alien limb phenomenon, or cortical sensory changes accompanied by akineto-rigid syndrome or dystoni...
Source: Neurology - February 24, 2014 Category: Neurology Authors: Lee, D.-W., Eum, S.-W., Moon, C. O., Ma, H.-I., Kim, Y. J. Tags: All Medical/Systemic disease, Corticobasal degeneration CLINICAL/SCIENTIFIC NOTES Source Type: research