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Early prediction and outcome of septic encephalopathy in acute stroke patients with nosocomial coma.
CONCLUSION: High fever and severe SIRS are two early predictors of stroke patients with SE, and survival rates were worse in stroke patients with SE than those without SE. PMID: 26015818 [PubMed]
Source: Clin Med Res - May 29, 2015 Category: Research Authors: Tong DM, Zhou YT, Wang GS, Chen XD, Yang TH Tags: J Clin Med Res Source Type: research

Ischemic Stroke and Septic Shock After Subacute Endocarditis Caused by Haemophilus parainfluenzae: Case Report.
Abstract Haemophilus parainfluenzae, which belongs to the HACEK (Haemophilus ssp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. A 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. Physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. The patient was admitted to hospital with progressive dyspnea, dry cough, and fever. Transesophageal echocardiog...
Source: Clin Med Res - December 8, 2016 Category: Research Authors: Menegueti MG, Machado-Viana J, Gaspar GG, Nicolini EA, Basile-Filho A, Auxiliadora-Martins M Tags: J Clin Med Res Source Type: research

Levosimendan Versus Dobutamine in Myocardial Injury Patients with Septic Shock: A Randomized Controlled Trial.
CONCLUSIONS Compared with dobutamine, levosimendan reduces biomarkers of myocardial injury and improves systemic hemodynamics in patients with septic shock. However, it does not reduce the days on mechanical ventilation, length of stay in ICU and hospital, or 28-day mortality. PMID: 27138236 [PubMed - in process]
Source: Medical Science Monitor - May 5, 2016 Category: Research Tags: Med Sci Monit Source Type: research

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages
In this study, we investigated the crosstalk between RANK and TLR4 pathways in macrophages stimulated with both RANKL and LPS to unveil the role of OPG in inflammatory processes. We found that RANKL inhibits TLR4 activation by binding to RANK, promoting the binding between TRAF6 and RANK, lowering TLR4 activation and the expression of proinflammatory mediators. Furthermore, high OPG levels aggravate inflammation by inhibiting RANKL. Our findings elect RANKL as a candidate for drug development as a way to mitigate the impact of obesity-induced inflammation in patients.PMID:35463988 | PMC:PMC9019442 | DOI:10.1155/2022/7740079
Source: Biomed Res - April 25, 2022 Category: Research Authors: Ryerson Fonseca Mota Paulo Henrique Cavalcanti de Ara újo Maria Eduarda Ramos Cezine Fl ávia Sayuri Matsuo Rodrigo Jair Morandi Metzner Carlos Alberto Oliveira de Biagi Junior Kamila Chagas Peronni Hiroki Hayashi Munehisa Shimamura Hironori Nakagami Mar Source Type: research