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Condition: Depression

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Feasibility of performing a multi-arm clinical trial examining the novel combination of repetitive transcranial magnetic stimulation and aerobic exercise for post-stroke depression
CONCLUSION: Performing a multi-arm combinatorial trial examining the effect of rTMS+AEx on PSD appears feasible. All treatment arms demonstrated strong adherence to their respective interventions and were well received. rTMS and the combination of AEx with rTMS may be alternative treatments for PSD.PMID:36606675 | DOI:10.1080/10749357.2023.2165258
Source: Topics in Stroke Rehabilitation - January 6, 2023 Category: Neurology Authors: Ryan E Ross Catherine J VanDerwerker Mark S George Chris M Gregory Source Type: research

The effects of low-intensity resistance training with blood flow restriction versus traditional resistance exercise on lower extremity muscle strength and motor functionin ischemic stroke survivors: a randomized controlled trial
CONCLUSION: LIRT-BFR produced a significant improvement in muscle strength, balance, walking capacity, and anxiety and depression in ischemic stroke patients, and the improvement are comparable to HIRT.CLINICAL TRIAL REGISTRATION: NCT05281679.PMID:37724785 | DOI:10.1080/10749357.2023.2259170
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Ishtiaq Ahmed Rustem Mustafoglu Belgin Erhan Source Type: research

Depression In Both Stroke Patients And Spouse Caregivers Influenced By Self-Esteem And Optimism
Self-esteem, optimism and perceived control influence depression in stroke survivors and their spouse caregivers - who should be treated together, according to research presented at the American Stroke Association's International Stroke Conference 2013. Researchers, who analyzed 112 depressed stroke survivors up to 8 weeks after hospital discharge and their spouses, found self-esteem and optimism influenced each partners' depression...
Source: Health News from Medical News Today - February 8, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

One In 12 Stroke Survivors Thinks About Suicide
About one in 12 stroke survivors in the U.S. thinks about committing suicide or wish that they were already dead. The finding came from a new study based on a nationally representative sample that was presented at the American Stroke Association's International Stroke Conference 2013. The number of people who experienced a stroke and had suicidal thoughts was surprising, compared with individuals who suffer from other health problems, explained lead researcher Amytis Towfighi, M.D...
Source: Health News from Medical News Today - February 8, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Stroke, Depression And Suicidal Thoughts
Nearly one in 12 American stroke survivors may have contemplated suicide or wished themselves dead, according to a study presented at the American Stroke Association's International Stroke Conference 2013. The proportion of stroke survivors who contemplated suicide was striking, compared with patients with other health conditions, said Amytis Towfighi, M.D., lead author of the study and an assistant professor of Clinical Neurology at the University of Southern California in Los Angeles and chair of the Department of Neurology at Rancho Los Amigos National Rehabilitation Center...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis
Conclusions The 5-HTTLPR SS genotype may be a risk factor for PSD. The 5-HTTLPR LL genotype showed a significant negative association with PSD. Further research to assess the sensitivity and specificity of predicting the risk of developing PSD by screening for the 5-HTTLPR genotype in stroke patients is required.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Mak, K. K., Kong, W. Y., Mak, A., Sharma, V. K., Ho, R. C. M. Tags: Genetics, Long term care, Drugs: CNS (not psychiatric), Stroke Cerebrovascular disease Source Type: research

Subjective Cognitive Complaints after Stroke: A Systematic Review
Conclusions: This review highlights that poststroke SCC are highly prevalent and that clinicians should take such complaints seriously. More research is, however, needed to gain further insight into poststroke SCC, to be able to accurately inform patients and relatives, and to develop adequate treatment programs. Based on the limitations of the studies to date, suggestions are made on how both future research and ultimately patient-centered care may be improved in stroke survivors.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Marielle W.A. van Rijsbergen, Ruth E. Mark, Paul L.M. de Kort, Margriet M. Sitskoorn Tags: Review Articles Source Type: research

Proteomics Reveals the Dysregulation of Lipid Metabolism in the Plasma of Post Stroke Depression Patients (P7.163)
CONCLUSIONS: These findings suggest that the perturbation of lipid metabolism and immunoregulation may be involved in the pathophysiology of major depressive disorder. Further investigation on these processes and proteins in PSD is key to understanding of the underlying pathophysiology of PSD.Disclosure: Dr. Mu has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Mu, J. Tags: Cerebrovascular Disease and Interventional Neurology: Post-Stroke Function Source Type: research

Increased Prevalence of Posttraumatic Stress Disorder in Patients After Transient Ischemic Attack Clinical Sciences
Conclusions— The experience of TIA increases the risk for PTSD and associated anxiety, depression, and reduced mental quality of life. Because a maladaptive coping style and a subjectively overestimated stroke risk seem to play a crucial role in this adverse progression, the training of adaptive coping strategies and cautious briefing about the realistic stroke risk associated with TIA might be a promising approach. Despite the great loss of patients to follow-up, the results indicate that PTSD after TIA requires increased attention.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Kiphuth, I. C., Utz, K. S., Noble, A. J., Kohrmann, M., Schenk, T. Tags: Behavioral/psychosocial - stroke, Transient Ischemic Attacks Clinical Sciences Source Type: research

Prestroke Living Situation and Depression Contribute to Initial Stroke Severity and Stroke Recovery
We examined prospectively collected stroke center database variables, which included prestroke living situation, to determine if social isolation could be determined from existing data using living arrangement as a proxy. Patients were categorized into 4 groups hypothesized to represent increasing levels of social isolation: living with spouse, living with family, living alone with visiting services, and living alone.
Source: Journal of Stroke and Cerebrovascular Diseases - December 15, 2014 Category: Neurology Authors: Abraham W. Aron, Ilene Staff, Gilbert Fortunato, Louise D. McCullough Tags: Original Article Source Type: research

Migraine Prophylaxis, Ischemic Depolarizations, and Stroke Outcomes in Mice Basic Sciences
Conclusions— These data underscore the importance of hyperexcitability as a mechanism for increased stroke risk in migraineurs, and suggest that migraine prophylaxis may not only prevent migraine attacks but also protect migraineurs against ischemic injury.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Eikermann-Haerter, K., Lee, J. H., Yalcin, N., Yu, E. S., Daneshmand, A., Wei, Y., Zheng, Y., Can, A., Sengul, B., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Ayata, C. Tags: Neuroprotectors Basic Sciences Source Type: research

Post-stroke depression (PSD) in sub-Saharan Africans- validation of the Japanese stroke scale for depression. (JSS-D). (P7.129)
CONCLUSIONS:JSS-D could be used for PSD with acceptable sensitivity and specificity in sub-Saharan Africans. Study Supported by:NONEDisclosure: Dr. Imarhiagbe has nothing to disclose. Dr. Afolabi has nothing to disclose. Dr. Kubeyinje has nothing to disclose. Dr. AKEMOKWE has nothing to disclose. Dr. Odiase has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Imarhiagbe, F., Afolabi, O., Kubeyinje, A., Akemokwe, F., Odiase, F. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke, Depression, and Anxiety Source Type: research

Cognition and major depression after frontal and cerebellar stroke (P7.133)
CONCLUSIONS: Results in individuals with frontal lobe CVA were consistent with previous studies showing associations between cognition and depression in other neurologic disease. Disconnection and disruption in brain regions involving both emotion regulation and cognition may explain these associations. Alternatively, or simultaneously, depression may transiently impair cognitive test performance after frontal lobe stroke. Study Supported by:Disclosure: Dr. Dulay has nothing to disclose. Dr. Agbayani has nothing to disclose. Dr. Gadhia has nothing to disclose. Dr. Lai has nothing to disclose. Dr. Volpi has nothing to discl...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dulay, M., Agbayani, K., Gadhia, R., Lai, J., Volpi, J., Chiu, D., Zhang, Y. J., Britz, G. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke, Depression, and Anxiety Source Type: research

Quality of Life Predictors in Chronic Stable Post-Stroke Patients and Prognostic Value of SF-36 Score as a Mortality Surrogate
In conclusion, anxiety, depression, and raised brain natriuretic peptide levels were the most important covariates of impaired QoL in post-stroke patients. Moreover, a decreased SF-36 score (≤40) represents an independent surrogate of increased additive mortality risk.
Source: Translational Stroke Research - August 14, 2015 Category: Neurology Source Type: research