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Condition: Obesity
Drug: Insulin
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Total 476 results found since Jan 2013.
Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Compr Physiol. 2021 Dec 29;12(1):3045-3084. doi: 10.1002/cphy.c210010.ABSTRACTMetabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL cholesterol, insulin resistance, hypertension, and central obesity. These diseases act synergistically in people suffering from MetS and dramatically increase risk of morbidity and mortality due to stroke and cardiovascular disease, as well as certain cancers. Each of these component features is itself a complex disease, ...
Source: Comprehensive Physiology - December 29, 2021 Category: Physiology Authors: Karen C Clark Anne E Kwitek Source Type: research
Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research
Diabetes Equates the Rich and the Poor
Diabetes test, Mauritius. Credit: Nasseem Ackbarally/IPSBy Bruno KappaNAIROBI, Nov 12 2021 (IPS) Although for different reasons, diabetes appears to be one of the few cases that put rich and poor societies at equal footing. In either case, diabetes is caused by wrong, dangerous to health nutritional habits.
In fact, people in industrialised countries tend to consume the so-called “junk food”, while in poor nations diabetes is caused by malnutrition and undernourishment.
And it is a seriously worrying health problem. In fact, globally, an estimated 422 million adults were living with diabetes as of 2014, compared to 108...
Source: IPS Inter Press Service - Health - November 12, 2021 Category: International Medicine & Public Health Authors: Bruno Kappa Tags: Global Headlines Health Source Type: news
Peripheral versus central insulin and leptin resistance: Role in metabolic disorders, cognition, and neuropsychiatric diseases
Neuropharmacology. 2021 Nov 8:108877. doi: 10.1016/j.neuropharm.2021.108877. Online ahead of print.ABSTRACTInsulin and leptin are classically regarded as peptide hormones that play key roles in metabolism. In actuality, they serve several functions in both the periphery and central nervous system (CNS). Likewise, insulin and leptin resistance can occur both peripherally and centrally. Metabolic disorders such as diabetes and obesity share several key features including insulin and leptin resistance. While the peripheral effects of these disorders are well-known (i.e. cardiovascular disease, hypertension, stroke, dyslipidem...
Source: Neuropharmacology - November 11, 2021 Category: Drugs & Pharmacology Authors: Jennifer M Erichsen Jim R Fadel Lawrence P Reagan Source Type: research
Association Between Relative Quadriceps Strength and Type 2 Diabetes Mellitus in Older Adults: The Yangpyeong Cohort of the Korean Genome and Epidemiology Study
CONCLUSIONS: Greater relative quadriceps strength is associated with reduced odds of T2DM in older adults after adjusting for potential confounders including body mass index.PMID:34697251 | DOI:10.1123/jpah.2021-0361
Source: Journal of Physical Activity and Health - October 26, 2021 Category: Sports Medicine Authors: Bong Kil Song Geon Hui Kim Jung Woon Kim Elizabeth C Lefferts Angelique G Brellenthin Duck-Chul Lee Yu-Mi Kim Mi Kyung Kim Bo Youl Choi Yeon Soo Kim Source Type: research
Causes and Consequences of Polycystic Ovary Syndrome: Insights from Mendelian Randomization
CONCLUSIONS: The accumulation of genome-wide association studies in PCOS has enabled multiple MR analyses identifying factors that may cause PCOS or be caused by PCOS. This knowledge will be critical to future development of measures to prevent PCOS in girls at risk as well as prevent complications in those who have PCOS.PMID:34669940 | DOI:10.1210/clinem/dgab757
Source: Clinical Breast Cancer - October 20, 2021 Category: Cancer & Oncology Authors: Tiantian Zhu Mark O Goodarzi Source Type: research
