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Direct Oral Anticoagulants versus Vitamin K Antagonists in Cirrhotic Patients with Atrial Fibrillation: Update of Systematic Review and Meta-Analysis
ConclusionDOACs are associated with more favorable safety outcomes and may be a feasible option of oral anticoagulant for individuals with atrial fibrillation and cirrhosis. Pending validation by randomized prospective studies, the findings of this study should be interpreted with caution.
Source: American Journal of Cardiovascular Drugs - August 28, 2023 Category: Cardiology Source Type: research

Comparison of the Efficacy and Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation and Concomitant Liver Cirrhosis: A Systematic Review and Meta-Analysis
ConclusionsCompared with warfarin in patients with AF and liver cirrhosis, DOACs appear to be associated with improved efficacy and safety outcomes. Randomized controlled trials are warranted to confirm these findings.
Source: American Journal of Cardiovascular Drugs - May 19, 2021 Category: Cardiology Source Type: research

Direct oral anticoagulants and warfarin in patients with cirrhosis: a comparison of outcomes
In conclusion DOACs appear to be a safe alternative to warfarin in patients with mild to moderate cirrhosis. Further studies are warranted to confirm these findings.
Source: Journal of Thrombosis and Thrombolysis - January 7, 2020 Category: Hematology Source Type: research

Non-vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients with Atrial Fibrillation and Liver Disease: A Meta-Analysis and Systematic Review
ConclusionsBased on current publications, the use of NOACs is at least non-inferior to warfarin in patients with AF and liver disease.
Source: American Journal of Cardiovascular Drugs - September 3, 2019 Category: Cardiology Source Type: research

Indications, Efficacy and Complications of Kcentra Use in Reversing Coagulopathy
ConclusionsKcentra was used in several off-label clinical settings, with comparable mortality among the coumadin, rivaroxaban and apixaban groups and no identifiable benefit in the setting of cirrhosis, DIC or antiplatelet medications, but with an increased incidence of deep vein thrombosis and stroke.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Sritharan, N., Triulzi, D. Tags: 401. Basic Science and Clinical Practice in Blood Transfusion: Poster III Source Type: research

The efficacy and safety of direct oral anticoagulants vs traditional anticoagulants in cirrhosis
ConclusionsDirect oral anticoagulant use in patients with cirrhosis may be as safe as traditional anticoagulants. Patients with cirrhosis at our center prescribed DOACs had less major bleeding events, while maintaining efficacy at preventing stroke or thrombosis.
Source: European Journal of Haematology - January 14, 2017 Category: Hematology Authors: Justine Hum, Joseph J. Shatzel, Janice H. Jou, Thomas G. Deloughery Tags: ORIGINAL ARTICLE Source Type: research

The efficacy and safety of direct oral anticoagulants vs. traditional anticoagulants in cirrhosis
ConclusionsDOAC use in cirrhotics may be as safe as traditional anticoagulants. Patients with cirrhosis at our center prescribed DOACs had less major bleeding events, while maintaining efficacy at preventing stroke or thrombosis.This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - December 22, 2016 Category: Hematology Authors: Justine Hum, Joseph J. Shatzel, Janice H. Jou, Thomas G. Deloughery Tags: Original Article Source Type: research

Alcoholic cardiomyopathy : The result of dosage and individual predisposition.
Authors: Maisch B Abstract The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites. Historical exa...
Source: Herz - September 3, 2016 Category: Cardiology Tags: Herz Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

Daily multivitamin supplements did not reduce risk for major CV events over > 10 years in men.
CONCLUSION Daily multivitamin supplements did not affect risk for major cardiovascular events over > 10 years in male physicians in the USA.Daily multivitamin supplements vs placebo in male physicians in the USA‡OutcomesMultivitaminPlaceboAt a median 11.2 yRRI (95% CI)§NNHMajor CV events12.0%11.7%1% (-8 to 9)NSFatal and nonfatal stroke4.5%4.2%6% (-9 to 22)NSRRR (CI)§NNTFatal and nonfatal MI4.3%4.6%7% (-9 to 20)NSAll-cause mortality18%19%5% (-2 to 11)NS‡CV = cardiovascular; MI = myocardial infarction; NS = not significant; other abbreviations defined in Glossary. RRI, RRR, and CI calculated from adjusted hazar...
Source: Annals of Internal Medicine - February 19, 2013 Category: Internal Medicine Authors: Fairfield KM Tags: Ann Intern Med Source Type: research