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P211  Aortitis: clinical experience within a tertiary centre
Conclusion Systemic inflammatory response syndrome was the commonest presenting feature. Those without GCA-like symptoms received a delayed diagnosis, which increases the risk of preventable vascular events. CT-PET remained the main diagnostic tool. Prednisolone treatment was prolonged with burdensome side- effects. Methotrexate remained the DMARD of choice, but leflunomide also showed good results. Vascular complications are common and need attention.Disclosure R.S. Andev: None.N. Ahmad: None.R. Luqmani: None.S. Dubey: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Biologics May Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High ‐Risk Lesions
ConclusionOur findings indicate that in RA, biologic DMARD use is associated with reduced CVD risk, protective calcification of noncalcified lesions, and lower likelihood of new plaque formation in patients with early atherosclerosis.
Source: Arthritis and Rheumatology - August 6, 2020 Category: Rheumatology Authors: George A. Karpouzas, Sarah R. Ormseth, Elizabeth Hernandez, Matthew J. Budoff Tags: Original Article Source Type: research

Biologics may prevent cardiovascular events in rheumatoid arthritis by inhibiting coronary plaque formation and stabilizing high ‐risk lesions
ConclusionIn rheumatoid arthritis, bDMARD use associated with reduced CVD risk, protective calcification of non ‐calcified lesions and lower likelihood of new plaque formation in patients with early atherosclerosis.
Source: Arthritis and Rheumatology - April 20, 2020 Category: Rheumatology Authors: George A Karpouzas, Sarah R Ormseth, Elizabeth Hernandez, Matthew J Budoff Tags: FULL LENGTH Source Type: research

Risk factors for severe cranial ischaemic complications in giant cell arteritis
ConclusionIncreasing age, jaw claudication and smoking predicted sCIC, while higher CRP decreased the risk of sCIC in our GCA cohort.
Source: Rheumatology - March 3, 2020 Category: Rheumatology Source Type: research

Respiratory and otolaryngologic manifestations of giant cell arteritis.
CONCLUSIONS: It is important to recognize these atypical presentations because they may be the sole initial manifestation of the disease. Early suspicion and confirmation of the diagnosis of GCA can help to prevent more catastrophic consequences of unrecognized disease, including stroke and blindness. PMID: 26016768 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - May 30, 2015 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Bilateral scalp necrosis as a rare but devastating complication of giant cell arteritis
We report a case of a man who presented with a 4-week history of bilateral scalp necrosis associated with headache, jaw claudication, temporal artery tenderness, and raised inflammatory markers. He did not have any visual loss. A diagnosis of GCA was made and he was started on high-dose steroids immediately. The scalp lesions did improve and his symptoms resolved without any visual loss but, sadly he died due to severe sepsis. This case report is important as it describes a rare but severe complication of a common large vessel vasculitis seen by both primary care physicians and rheumatologists. Prompt recognition and early...
Source: Clinical Rheumatology - January 1, 2015 Category: Rheumatology Source Type: research