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Malignant Hyperthermia: A Killer If Ignored
J Perianesth Nurs. 2022 Apr 9:S1089-9472(21)00353-1. doi: 10.1016/j.jopan.2021.08.018. Online ahead of print.ABSTRACTMalignant hypothermia (MH) is a potentially fatal hypermetabolic reaction of skeletal muscle. It is an autosomal dominant disorder that generally occurs in people with RYR1, CACNA1S, or STAC3 mutations. And these genetic abnormalities often cause the imperfection of calcium release channels of skeletal muscle. The incidence of MH among different racial groups across the world ranges from approximately 1:5,000-1:250,000, but there is no national statistic MH incidence in China. It is not clear whether there a...
Source: Journal of Perianesthesia Nursing - April 13, 2022 Category: Nursing Authors: Xin Bin Baisheng Wang Zhangui Tang Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury.
This article reviews the pathophysiology of secondary brain injury relevant to ICH, examines pertinent experimental models, and highlights emerging therapeutic strategies. Treatment paradigms discussed include thrombin inhibitors, deferoxamine, minocycline, statins, granulocyte-colony stimulating factors, and therapeutic hypothermia. Despite promising experimental and preliminary human data, further studies are warranted prior to effective clinical translation. PMID: 23634928 [PubMed - in process]
Source: Neurosurgical Focus - May 1, 2013 Category: Neurosurgery Authors: Belur PK, Chang JJ, He S, Emanuel BA, Mack WJ Tags: Neurosurg Focus Source Type: research