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Continuous cerebral and myocardial selective perfusion in neonatal aortic arch surgery
ConclusionCCMSP is a safe and reproducible strategy for cerebral, myocardial and visceral protection in neonatal aortic arch repair, with or without VSD closure, resulting in low complication and mortality.
Source: Journal of Cardiac Surgery - October 21, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Pierre Maminirina, Carine Pavy, Pierre Bourgoin, Olivier Baron Tags: ORIGINAL ARTICLE Source Type: research

Moderate hypothermia >=24 and
CONCLUSIONS Moderate hypothermia for HCA during ACP is being used with increasing frequency, but has not been thoroughly evaluated in patients undergoing cardiovascular reoperations. Our experience suggests that in patients with previous cardiac surgery who are undergoing hemiarch and total aortic arch operations, moderate hypothermia is safe and produces respectable results.
Source: European Journal of Cardio-Thoracic Surgery - November 3, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Preventza, O., Garcia, A., Kashyap, S. A., Akvan, S., Cooley, D. A., Simpson, K., Rammou, A., Price, M. D., Omer, S., Bakaeen, F. G., Cornwell, L. D., Coselli, J. S. Tags: Extracorporeal circulation, Pericardium, Vascular malformations AORTIC SURGERY Source Type: research

Is moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion superior to deep hypothermic circulatory arrest in elective aortic arch surgery?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether moderate hypothermia circulatory arrest with selective antegrade cerebral perfusion (SACP) is more beneficial than deep hypothermic circulatory arrest in elective aortic arch surgery. Altogether, 1028 papers were found using the reported search, of which 6 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. There were four retrospective obser...
Source: Interactive CardioVascular and Thoracic Surgery - August 21, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Poon, S. S., Estrera, A., Oo, A., Field, M. Tags: Extracorporeal circulation Adult Cardiac Source Type: research

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Publication date: Available online 11 May 2016 Source:The Lancet Neurology Author(s): Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research

Moderate Versus Deep Hypothermia With Unilateral Selective Antegrade Cerebral Perfusion for Acute Type A Dissection
Conclusions Moderate HCA with uSACP is an effective circulation management strategy that provides excellent cerebral and visceral protection during emergent ATAAD repair. In the setting of antegrade cerebral perfusion, deep hypothermia does not provide any additional benefit.
Source: The Annals of Thoracic Surgery - October 30, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Moderate Versus Deep Hypothermia With Unilateral Selective Antegrade Cerebral Perfusion for Acute Type A Dissection.
CONCLUSIONS: Moderate HCA with uSACP is an effective circulation management strategy that provides excellent cerebral and visceral protection during emergent ATAAD repair. In the setting of antegrade cerebral perfusion, deep hypothermia does not provide any additional benefit. PMID: 26233273 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 30, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Leshnower BG, Thourani VH, Halkos ME, Sarin EL, Keeling WB, Lamias MJ, Guyton RA, Chen EP Tags: Ann Thorac Surg Source Type: research

Recent thoraco-abdominal aortic repair outcomes using moderate-to-deep hypothermia combined with targeted reconstruction of the Adamkiewicz artery
CONCLUSIONS Moderate-to-deep hypothermia combined with targeted reconstruction of the AKA provided satisfactory outcomes with thoraco-abdominal aortic repair, particularly for spinal cord protection.
Source: Interactive CardioVascular and Thoracic Surgery - April 22, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tanaka, H., Minatoya, K., Sasaki, H., Seike, Y., Itonaga, T., Oda, T., Kobayashi, J. Tags: Pericardium Adult Cardiac Source Type: research

210 * contemporary approach of thoraco-abdominal aortic repair using moderate to deep hypothermia combined with target reconstruction of the adamkiewicz artery
Conclusion: Moderate to deep hypothermia combined with target reconstruction of the Adamkiewicz artery brings satisfactory outcomes in thoraco-abdominal aortic repair, especially for spinal cord protection.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Tanaka, H., Minatoya, K., Sasaki, H., Oda, T., Itonaga, T., Kobayashi, J. Tags: Thoraco-abdominal aortic repair reloaded Source Type: research

Predictors of electrocerebral inactivity with deep hypothermia
Conclusions: Cooling to a nasopharyngeal temperature of 12.7°C or for a duration of 97 minutes achieved ECI in>95% of patients in our study population. However, patient-specific factors were poorly predictive of the temperature or cooling time required to achieve ECI, necessitating EEG monitoring for precise ECI detection.
Source: The Journal of Thoracic and Cardiovascular Surgery - April 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Michael L. James, Nicholas D. Andersen, Madhav Swaminathan, Barbara Phillips-Bute, Jennifer M. Hanna, Gregory R. Smigla, Michael E. Barfield, Syamal D. Bhattacharya, Judson B. Williams, Jeffrey G. Gaca, Aatif M. Husain, G. Chad Hughes Tags: Acquired Cardiovascular Disease Source Type: research

Seek and You Shall Find—But Then What Do You Do? Cold Agglutinins in Cardiopulmonary Bypass and a Single-Center Experience With Cold Agglutinin Screening Before Cardiac Surgery
Abstract: Cardiopulmonary bypass (CPB) during cardiac surgery can involve deliberate hypothermia of the systemic (22-36°C) and coronary circulations (as low as 8-12°C). Adverse sequelae of cold-active antibodies have been feared and reported under such conditions, and some centers thus elect to screen for cold agglutinins before CPB. We reviewed the literature on cold agglutinins in cardiac surgery and described the yields and effects of cold agglutinin screening (CAS) in 14900 cardiac surgery patients undergoing CPB over 8 years at a single institution. Cold agglutinin screening was positive in 47 cases (0.3%), at an an...
Source: Transfusion Medicine Reviews - February 4, 2013 Category: Hematology Authors: Michael D. Jain, Rosa Cabrerizo-Sanchez, Keyvan Karkouti, Terrence Yau, Jacob M. Pendergrast, Christine M. Cserti-Gazdewich Tags: Original Articles Source Type: research