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Free fatty acids to predict recurrent ischemic stroke
Recurrent stroke accounts for substantial morbidity and mortality among ischemic stroke survivors. To establish effective treatments for secondary stroke prevention, it is important to determine factors associated with stroke recurrence. Among the blood biomarkers associated with stroke risk, lipoprotein-associated phospholipase A2 (LpPLA2) is perhaps the most studied. LpPLA2 hydrolyzes oxidized phospholipids and plays an important role in atherosclerosis with elevated plasma levels associated with increased risk of ischemic stroke and myocardial infarction. Other markers associated with stroke risk include fibrinogen, C-r...
Source: Neurology - March 31, 2014 Category: Neurology Authors: Jickling, G. C., Spence, J. D. Tags: All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Weather as physiologically equivalent was not associated with ischemic stroke onsets in Vienna, 2004-2010.
Abstract Stroke rates were found to have seasonal variations. However, previous studies using air temperature, humidity, or air pressure separately were not adequate, and the study catchment was not clearly drawn. Therefore, here we proposed to use a thermal index called physiologically equivalent temperature (PET) that incorporates air temperature, humidity, wind speed, cloud cover, air pressure and radiation flux from a biometeorological approach to estimate the effect of weather as physiologically equivalent on ischemic stroke onsets in an Austrian population. Eight thousand four hundred eleven stroke events in...
Source: Environmental Science and Pollution Research International - April 16, 2015 Category: Environmental Health Authors: Ferrari J, Shiue I, Seyfang L, Matzarakis A, Lang W, Austrian Stroke Registry Collaborators Tags: Environ Sci Pollut Res Int Source Type: research

Comprehensive Stroke Centers May Be Associated With Improved Survival in Hemorrhagic Stroke Stroke
Conclusions Hemorrhagic stroke patients admitted to CSCs are more likely to receive neurosurgical and endovascular treatments and be alive at 90 days than patients admitted to other hospitals.
Source: JAHA:Journal of the American Heart Association - May 6, 2015 Category: Cardiology Authors: McKinney, J. S., Cheng, J. Q., Rybinnik, I., Kostis, J. B., the Myocardial Infarction Data Acquisition System (MIDAS 22) Study Group Tags: Stroke Source Type: research

Design of Randomized, double‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
DiscussionAcetylsalicylic acid is the most common antithrombotic given to patients with embolic strokes of undetermined source to reduce recurrence risk. This trial will determine whether anticoagulation with dabigatran is more effective than acetylsalicylic acid, and acceptably safe.
Source: International Journal of Stroke - September 30, 2015 Category: Neurology Authors: Hans‐Christoph Diener, J. Donald Easton, Christopher B. Granger, Lisa Cronin, Christine Duffy, Daniel Cotton, Martina Brueckmann, Ralph L. Sacco, Tags: Protocol Source Type: research

Copeptin and Long-Term Risk of Recurrent Vascular Events After Transient Ischemic Attack and Ischemic Stroke: Population-Based Study Clinical Sciences
Conclusions— In patients with TIA and ischemic stroke, copeptin predicted recurrent vascular events and death, particularly after cardioembolic TIA/stroke. Further validation is required, in particular, in studies using more extensive cardiac evaluation.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Greisenegger, S., Segal, H. C., Burgess, A. I., Poole, D. L., Mehta, Z., Rothwell, P. M. Tags: Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

A Retrospective Study of Stroke in Women Compared to Men in Outcome and Readmission Causes (P1.216)
Conclusion:This study is among the first to discuss stroke in minority population in the Middle East. We did not identify sex as an important determinant of outcome after an acute ischemic stroke in this study.Disclosure: Dr. AlShaer has nothing to disclose. Dr. Khoja has nothing to disclose. Dr. Rammal has nothing to disclose. Dr. Almekhlafi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: AlShaer, D., Khoja, A., Rammal, S., Almekhlafi, M. Tags: Re-admission and Stroke Outcomes Source Type: research

Design of Randomized, double ‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
DiscussionAcetylsalicylic acid is the most common antithrombotic given to patients with embolic strokes of undetermined source to reduce recurrence risk. This trial will determine whether anticoagulation with dabigatran is more effective than acetylsalicylic acid, and acceptably safe.
Source: International Journal of Stroke - September 29, 2015 Category: Neurology Authors: Hans ‐Christoph Diener, J. Donald Easton, Christopher B. Granger, Lisa Cronin, Christine Duffy, Daniel Cotton, Martina Brueckmann, Ralph L. Sacco, Tags: Protocol Source Type: research

Association between percent decline in serum total homocysteine and risk of first stroke
Conclusions: Percent lowering in tHcy was significantly associated with a reduction in first stroke risk in Chinese adults with hypertension, and if further confirmed, may serve as a useful indicator for folic acid treatment efficacy on stroke prevention. Clinicaltrials.gov identifier: NCT00794885.
Source: Neurology - November 13, 2017 Category: Neurology Authors: Huang, X., Li, Y., Li, P., Li, J., Bao, H., Zhang, Y., Wang, B., Sun, N., Wang, J., He, M., Yin, D., Tang, G., Chen, Y., Cui, Y., Huang, Y., Hou, F. F., Qin, X., Huo, Y., Cheng, X. Tags: Stroke prevention, All Clinical trials ARTICLE Source Type: research

The China Stroke Secondary Prevention Trial (CSSPT) protocol: a double‐blinded, randomized, controlled trial of combined folic acid and B vitamins for secondary prevention of stroke
DiscussionThis is the first multicenter randomized trial of secondary prevention for ischemic stroke in a Chinese population with a higher homocysteine level but without folate food fortification.
Source: International Journal of Stroke - March 12, 2013 Category: Neurology Authors: Xuedong Liu, Ming Shi, Feng Xia, Junliang Han, Zhirong Liu, Bo Wang, Fang Yang, Li Li, Songdi Wu, Ling Wang, Nan Liu, Yali Lv, Gang Zhao Tags: Protocols Source Type: research

A double‐blind placebo‐controlled clinical evaluation of MultiStem for the treatment of ischemic stroke
Conclusions and future directionIf MultiStem is safe and there is a signal of efficacy, a late stage phase IIb‐III trial is planned.
Source: International Journal of Stroke - May 24, 2013 Category: Neurology Authors: David C. Hess, Cathy A. Sila, Anthony J. Furlan, Larry R. Wechsler, Jeffrey A. Switzer, Robert W. Mays Tags: Protocols Source Type: research

Predictors of in‐hospital death and symptomatic intracranial hemorrhage in patients with acute ischemic stroke treated with thrombolytic therapy: Paul Coverdell Acute Stroke Registry 2008–2012
ConclusionsIn this study of acute ischemic stroke patients, older age, male gender, National Institutes of Health Stroke Scale score, history of myocardial infarction or coronary artery disease, and history of atrial fibrillation were associated with increased in‐hospital death among patients receiving intravenous tissue plasminogen activator. Among patients treated with intravenous tissue plasminogen activator, in‐hospital mortality and symptomatic intracerebral hemorrhage rates were similar between those treated within three‐hours of time last known to be well and those treated between three and 4·5 hours after this time.
Source: International Journal of Stroke - September 12, 2013 Category: Neurology Authors: Xin Tong, Mary G. George, Quanhe Yang, Cathleen Gillespie Tags: Research Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after the occurrence of HZ.
Source: Neurology - January 20, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gauthier, A., Brown, M. M. Tags: Stroke in young adults, Viral infections, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Electrocardiographic Assessment of Coronary Artery Disease and Stroke Risk Factors in Rural and Urban Tanzania: A Case–control Study
Conclusions: This is the first published study of ECG assessment of CAD and other stroke risk factors in an incident population of stroke cases in sub-Saharan Africa. It suggests that concomitant CAD in black African stroke cases is more common than previously suggested.
Source: Journal of Stroke and Cerebrovascular Diseases - April 1, 2013 Category: Neurology Authors: Richard W. Walker, Matthew Dewhurst, William K. Gray, Ahmed Jusabani, Eric Aris, Nigel Unwin, Mark Swai, Philip C. Adams, Ferdinand Mugusi Tags: Original Articles Source Type: research

Influenza vaccination and cardiovascular risk in patients with recent TIA and stroke
Conclusions: Influenza vaccination was not associated with reduced outcome events in patients with recent atherothrombotic ischemic stroke after considering all baseline characteristics (including concomitant medications) associated with influenza vaccination.
Source: Neurology - May 26, 2014 Category: Neurology Authors: Lavallee, P. C., Labreuche, J., Fox, K. M., Lavados, P., Mattle, H., Steg, P. G., Amarenco, P., On behalf of the PERFORM, OPTIC, and AMISTAD Investigators Tags: Stroke prevention, Viral infections, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Incidence, Trends, and Predictors of Ischemic Stroke 1 Year After an Acute Myocardial Infarction Clinical Sciences
Conclusions— The risk of ischemic stroke within a year after myocardial infarction is substantial but has clearly been reduced during the studied time period. The major predictive factors found to correlate well with previous investigations. Reperfusion treatment, thrombocyte aggregation inhibition, and lipid lowering are the main contributors to the observed risk reduction.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Ulvenstam, A., Kajermo, U., Modica, A., Jernberg, T., Soderstrom, L., Mooe, T. Tags: Platelet function inhibitors, Acute myocardial infarction, Acute Cerebral Infarction, Platelets Clinical Sciences Source Type: research