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Source: Neurology
Condition: Aphasia

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Total 134 results found since Jan 2013.

Effect of informed consent on patient characteristics in a stroke thrombolysis trial
Conclusions: Patients recruited by proxy consent were older, had more severe strokes, and had higher prevalence of aphasia than those with capacity to give personal consent. Variations in the manner of consent across countries may influence trial results. Clinicaltrials.gov and Clinicaltrialsregister.eu identifiers: NCT01525290 (clinicaltrials.gov); 2011-005906-32 (clinicaltrialsregister.eu).
Source: Neurology - September 25, 2017 Category: Neurology Authors: Thomalla, G., Boutitie, F., Fiebach, J. B., Simonsen, C. Z., Nighoghossian, N., Pedraza, S., Lemmens, R., Roy, P., Muir, K. W., Heesen, C., Ebinger, M., Ford, I., Cheng, B., Cho, T.-H., Puig, J., Thijs, V., Endres, M., Fiehler, J., Gerloff, C. Tags: MRI, All Clinical trials, All Cerebrovascular disease/Stroke, Clinical trials Methodology/study design, All Ethics in Neurology/Legal issues ARTICLE Source Type: research

Comment: Capacity, consent, and country in acute stroke research
As a general principle, any research involving humans requires voluntary participation based on informed consent.1 This also applies to enrollment in clinical trials und usually requires participants to give written informed consent after having received detailed information about potential benefits and risks as well as alternative treatment options, and after having had adequate time for consideration. Trials in acute stroke, however, present several challenges to this approach. Reperfusion therapies in acute stroke show a clear time-dependent effect, being more effective the earlier treatment is started, or reperfusion a...
Source: Neurology - September 25, 2017 Category: Neurology Authors: Chen, D. T., Worrall, B. B. Tags: ARTICLE Source Type: research

Intra-arterial milrinone may differentiate fulminant RCVS from vasculitis
A 39-year-old woman taking a monoamine oxidase inhibitor presented with a 1-week history of severe non-thunderclap headache and visual field deficits. Brain CT showed infarcts in both parietal lobes, with narrowing of intracranial vessels on CT angiogram (figure 1), suggesting either vasculitis or reversible cerebral vasoconstriction syndrome (RCVS). Despite treatment with both methylprednisolone and nimodipine, she experienced progressive aphasia and right leg weakness. She underwent an urgent cerebral angiogram (figure 2), during which intra-arterial milrinone reversed both the vasoconstriction and its symptoms, thereby ...
Source: Neurology - September 4, 2017 Category: Neurology Authors: Laneuville, M., Ding, J., Shamy, M., Lum, C., Dowlatshahi, D. Tags: All Headache, Other cerebrovascular disease/ Stroke NEUROIMAGES Source Type: research

Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research

MELAS Syndrome: How Stroke-like are the Stroke episodes? (P1.255)
Conclusions:Patients with MELAS syndrome may present with recurrent strokes in the arterial territory rather than SLEs. Clinicians should entertain the possibility of a mitochondrial disease in young patients with cryptogenic stroke and pursue appropriate diagnostic evaluations and treatment.Disclosure: Dr. Liaw has nothing to disclose. Dr. Lewis has nothing to disclose. Dr. Saini has nothing to disclose. Dr. Gultekin has nothing to disclose. Dr. Koch has nothing to disclose. Dr. Asdaghi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Liaw, N., Lewis, R., Saini, V., Gultekin, S. H., Koch, S., Asdaghi, N. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Characterization of Primary Progressive Aphasia and Prediction of Naming Decline by Multi-Modality MRI (N1.002)
Conclusions:Multi-modality analysis of brain MRI reveals differences in brain structure and function between PPA and controls and is potentially useful for refining prediction of later performanceStudy Supported by: NIH-NINDS R01DC011317, R01 NS047691Disclosure: Dr. Faria has nothing to disclose. Dr. Meyer has nothing to disclose. Dr. Tippett has nothing to disclose. Dr. Friedman has nothing to disclose. Dr. Hillis has received personal compensation in an editorial capacity for American Heart Association for serving as Associate Editor of Stroke and Elsevier for serving as Associate Editor of Practice Update Neurology.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Faria, A., Meyer, A., Tippett, D., Friedman, R., Hillis, A. Tags: Neuroscience in the Clinic: Neurobiology and Treatment of Disorders of Language and Action Source Type: research

Analysis of Run Sheets of EMS Serving a Metropolitan Comprehensive Stroke Center (P1.268)
Conclusions:Patients with acute stroke transported by EMS have better quality metrics and higher chance of receiving acute treatment. EMS documented assessment allows for the diagnosis or stroke in general but cannot identify LVO because the assessment of cortical signs is very limited.Disclosure: Dr. Hussein has nothing to disclose. Dr. Kashyap has nothing to disclose. Dr. Erickson has nothing to disclose. Dr. Forsberg has nothing to disclose. Dr. Burnett has nothing to disclose. Dr. Stanfield has nothing to disclose. Dr. Wewerka has nothing to disclose. Dr. Terwilliger has nothing to disclose. Dr. Hanson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Hussein, H., Kashyap, B., Erickson, L., Forsberg, A., Burnett, A., Stanfield, S., Wewerka, S., Terwilliger, A., Hanson, L. Tags: Pre-Hospital Stroke, Tele-Stroke, and mHealth Source Type: research

Recurrent transient hemiparesis and a novel ATP1A2 mutation (P3.220)
Conclusions:This case identifies a novel, potentially pathogenic mutation of the ATP1A2 gene corresponding to a phenotype of a rare migraine variant and contributes to our evolving understanding of migraine molecular genetics and pathophysiology.Study Supported by:Disclosure: Dr. Stredny has nothing to disclose. Dr. Winden has nothing to disclose. Dr. Danehy has nothing to disclose. Dr. Robertson has nothing to disclose. Dr. Trenor has nothing to disclose. Dr. Rivkin has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Bernson-Leung has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stredny, C., Winden, K., Danehy, A., Robertson, R., Trenor, C., Rivkin, M., Lehman, L., Bernson-Leung, M. Tags: Child Neurology I Source Type: research

4-year-old boy with acute ischemic stroke treated with intravenous tissue plasminogen activase. (P1.285)
Conclusions:The TIPS trial is underway, which utilizes a classic safety dose finding method to select a safe dose of IV tPA. The child in our case was successfully treated with a dose of 0.75 mg/kg of IV tPA. It has been suggested the appropriate dose may actually be higher than the standard used in adults due to the developmental trajectory of the fibrinolytic system during childhood, as children have lower endogenous tPA and higher plasminogen activator inhibitor-1 levels.Disclosure: Dr. Derani has nothing to disclose. Dr. Kassab has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Derani, T., Kassab, M. Tags: Cerebrovascular Disease Case Reports I Source Type: research

Subcortical aphasias-questioning validity of aphasia as a cortical infarct sign (p1.287)
Conclusions:Given that a small subcortical infarction can present as pure aphasia, the belief that aphasia is always a sign of a cortical infarct is unfounded and should be revisited.Disclosure: Dr. Kaur has nothing to disclose. Dr. Culebras received personal compensation in an editorial capacity for Medlink and UpToDate.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kaur, G., Culebras, A. Tags: Cerebrovascular Disease Case Reports I Source Type: research

To describe symptomatology and etiological factors of posterior fossa strokes involving only the basilar artery. (P3.257)
Conclusions:Muscle weakness, language changes were the primary symptoms recorded when patients presented with posterior fossa strokes involving only the basilar artery. LVAT and cardio-embolism were the primary etiologies. This study elucidates symptoms to look for when patients present with muscle weakness as well as language changes, and emphasizes the possibility of cardiac causes of posterior fossa strokes involving purely the basilar artery.Study Supported by:The patients evaluated with only basilar stroke and at least one of the following symptoms: 72.6% (53/73) muscle weakness, 64.4% (47/73) language changes, 40.0% ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parand, L., Jillella, D., Zafar, A. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Clinical and Radiological Features of Antiphospholipid Antibody Syndrome Associated with Stroke (P3.266)
Conclusions:aPLS associated strokes are predominantly perisylvian in location in the territory of MCA branches. The clinical and radiological features are similar to cardioembolic strokes.aPLS testing should be considered in all young patients with suggestive clinical and radiological features in addition to cardiac work up.Disclosure: Dr. Khayat has nothing to disclose. Dr. Alkully has nothing to disclose. Dr. Milyani has nothing to disclose. Dr. Almekhlafi has nothing to disclose. Dr. Alshanqiti has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Khayat, A., Alkully, H., Milyani, H., Almekhlafi, M., Alshanqiti, M. Tags: Cerebrovascular Disease Epidemiology Source Type: research

Chronic Blood-Brain Barrier Disruption: a case report (P3.275)
Conclusions:WMH-associated BBB disruption maybe exacerbated by acute stroke, and can persist for months after the initial event, as manifest on BBB permeability imaging. These findings may offer insight into the pathophysiology of vascular dementia.Disclosure: Dr. Naqvi has nothing to disclose. Dr. Hitomi has nothing to disclose. Dr. Leigh has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Naqvi, I., Hitomi, E., Leigh, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Aphemia: A rare presentation of an acute infarct (P3.277)
Conclusions:Aphemia, or apraxia of speech, is a rare presentation of dominant inferior frontal gyrus infarction. Aphemia is primarily a disorder of articulation, whereas aphasia is a disorder of language. This patient lost her ability to produce speech but was able to comprehend and write fluently. Her deficit did not fit a classic aphasia pattern but rather represented an inability to voluntarily control her oral muscles, resulting in a transient apraxia of the muscles of articulation, chewing, and deglutition. Very few cases of acute aphemia due to stroke are described, all localized to the dominant inferior frontal gyru...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stachyra, J., Davalos-Balderas, A., Lee, J., Kass, J. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research