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Transcranial Direct Current Stimulation in Post-Stroke Aphasia: The Impact of Baseline Severity and Task Specificity (P4.206)
Conclusions:The results suggest that for at least some outcome measures, baseline severity may be an important factor in predicting the response to tDCS in patients with chronic non-fluent aphasia. Moving forward, the ability to identify patient factors that can predict response could help refine strategies for the administration of therapeutic tDCS, focusing attention on those patients most likely to benefit from stimulation.Disclosure: Dr. Norise has nothing to disclose. Dr. Sacchetti has nothing to disclose. Dr. Hamilton has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Norise, C., Sacchetti, D., Hamilton, R. Tags: Behavioral and Cognitive Neurology: Language Source Type: research

Overrepresentation of isolated verbal repetition deficits in aphasic males with stroke: A systematic literature review and meta-analysis (P4.211)
Conclusions:Chronic isolated repetition deficits are more prevalent in men than in women. This finding is clinically relevant because of repetition’s role in language acquisition and recovery, being a main mechanism by which children learn to speak and a major resource in language rehabilitation techniques.Disclosure: Dr. Pertierra has nothing to disclose. Dr. Torres Prioris has nothing to disclose. Dr. Dávila has nothing to disclose. Dr. Allegri has nothing to disclose. Dr. Berthier has received personal compensation for activities with Pfizer/Eisai, Merz, Lundbeck, GlaxoSmithKline, Eli Lilly, Novartis and Ja...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pertierra, L., Prioris, M. J. T., Davila, M. G., Allegri, R., Torres, M. B. Tags: Behavioral and Cognitive Neurology: Language Source Type: research

Revised Constraint-Induced Aphasia Therapy (CIAT II): Neuroscience Foundations Traced from Basic Laboratory Research to Increased Spontaneous Real-World Speech and Cerebral Cortical Structure (P4.217)
Conclusions:CIAT II has promise for promoting enduring increased spontaneous real-world speech as well as brain structure for chronic aphasia, convergent with earlier forms of CI therapies for movement. Further trials are warranted.Study Supported by: NIH grant HD0 53750.Disclosure: Dr. Mark has nothing to disclose. Dr. Taub has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mark, V., Taub, E. Tags: Neuro-rehabilitation: Mechanism of Recovery Source Type: research

Stroke like migraine attacks after radiation therapy (SMART) syndrome a case series of three patients (P6.179)
Conclusions:Our patients represent the first case series of SMART syndrome in a single institution. Our cases share similarities to the prior reports in the literature and highlights the clinical and MRI triad of acute onset headaches, neurological deficits and MRI findings of transient contrast enhancement of the cortex with white matter sparing in a previous radiation field.Disclosure: Dr. rauf has nothing to disclose. Dr. Boulter has nothing to disclose. Dr. Imitola has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Rauf, Y., Boulter, D., Imitola, J. Tags: Neurologic Complications of Cancer Source Type: research

"BEAST" at the University Of Virginia: Demographic and Phenotypic Data of Patients Contributing to a Biorepository to Establish the Etiology Of Sinovenous Thrombosis (P6.260)
Conclusions:Understanding the association between genetic determinants of CVST and phenotype has the potential to advance the diagnosis and management of this challenging entity. Enrollment in BEAST continues, with a replication cohort GWAS anticipated.Disclosure: Dr. Chiota-McCollum has nothing to disclose. Dr. Ehrlich has nothing to disclose. Dr. Johansen has received research support from the Graduate Medical Office at the University of Virginia for a quality improvement project investigating stroke in the setting of cardiac catheterization. . Dr. Rahman has nothing to disclose. Dr. Chapman has nothing to disclose. Dr. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chiota-McCollum, N., Ehrlich, M., Johansen, M., Rahman, S., Chapman, S., Worrall, B. Tags: Non-Atherosclerotic Angiopathies and Cerebral Venous Thrombosis Source Type: research

Transcranial Direct Current Stimulation in Post-Stroke Aphasia Rehabilitation: Bilateral vs Unilateral Online Stimulation (P5.151)
Conclusions:tDCS showed to be an effective and safe tool in improving post-stroke patients’ aphasic symptoms, with no difference between the two montages employed, even if these results have to be considered preliminary, since we are still widening our sample. IFG stimulation is worth to be further explored (wider samples and evaluation for optimal stimulation parameters) as additional rehabilitative tool for post stroke aphasic patients.Disclosure: Dr. Torrente has nothing to disclose. Dr. Giglia has nothing to disclose. Dr. Di Stefano has nothing to disclose. Dr. Gangitano has nothing to disclose. Dr. Piccoli has n...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Torrente, A., Giglia, G., Di Stefano, V., Gangitano, M., Piccoli, T., Costa, V., Fierro, B., Sack, A. T., Brighina, F. Tags: Clinical Neuro-rehabilitation Source Type: research

Harmonizing Together: Speech and Music Therapy and Support for Patients and Partners with PPA (P5.157)
Conclusions:The reports of improvement in caregiver health, social participation of patients, and functional communication are in line with the group’s focus and goals. In contrast, more comprehensive knowledge of the disease process may have led patients and caregivers to experience greater feelings of guilt and fear. Our qualitative observations and reports from participants indicated that the most beneficial parts of the group were raising patients’ confidence in communication and allowing both patients and families suffering from PPA to connect with one another.Study Supported by:Funding NIH grant NS077059;...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Quimby, M., Shaprio-Gordon, J., Brandt, K., Hyatt, C., Grimm, M., Richardson, L., Howland, K., Dickerson, B. Tags: Clinical Neuro-rehabilitation Source Type: research

Contrast induced encephalopathy mimicking reperfusion injury (P3.285)
Conclusions:Diagnostic or therapeutic angiography is frequently performed for acute ischemic or hemorrhagic stroke. Clinicians should be aware of contrast induced encephalopathy and consider it in cases of neurologic deterioration after angiography in order to initiate appropriate treatment and avoid unnecessary invasive tests.Disclosure: Dr. Bakradze has nothing to disclose. Dr. Pasquale has nothing to disclose. Dr. Kirchoff-Torres has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bakradze, E., Pasquale, D., Kirchoff-Torres, K. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Pediatric Thrombectomy: Case Presentation and Standardizing the INR process. (P4.149)
Conclusions:Endovascular therapy should be considered in pediatric patients, and consensus guidelines and processes for implementation are needed to ensure this therapy is given appropriately, efficiently and safely.Disclosure: Dr. Bushlin has nothing to disclose. Dr. Wilson has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bushlin, I., Wilson, J. Tags: Child Neurology II Source Type: research

Hypoperfusion, vascular pruning, and transient hemiparesis mimicking stroke in transient erythroblastopenia of childhood (P4.161)
Conclusions:The patient’s transient cerebrovascular and electrophysiologic abnormalities are consistent with those described in the literature for hemiplegic migraine. However, he did not meet International Headache Society criteria for hemiplegic migraine, such as headache with presentation or recurrent events. We hypothesize that transient vascular narrowing and resultant hypoperfusion, compounded by cerebral hypoxia from significant anemia, may explain the transient neurologic symptoms concurrent with anemia in TEC.Disclosure: Dr. Calahan has nothing to disclose. Dr. Lehman has nothing to disclose. Dr. Rivkin has ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Calahan, C., Lehman, L., Rivkin, M., Lipton, J., Danehy, A., Robertson, R., Ozuah, N., Trenor, C., Bernson-Leung, M. Tags: Child Neurology II Source Type: research

Gender Differences in Post Stroke Fatigue (P5.290)
Conclusions:In our urban predominately minority cohort, women had more severe PSF than men. The basis for the protective effect of HTN on PSF severity is unclear and deserves further study.Disclosure: Dr. Balucani has nothing to disclose. Dr. Gilles has nothing to disclose. Dr. Singer has nothing to disclose. Dr. Stefanov has nothing to disclose. Dr. Halket has nothing to disclose. Dr. Mlastabi has nothing to disclose. Dr. Huang has nothing to disclose. Dr. Weingast has nothing to disclose. Dr. Levine has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Balucani, C., Gilles, N., Singer, J., Stefanov, D., Halket, D., Mlastabi, J., Huang, A., Weingast, S., Levine, S. Tags: Stroke Recovery and Rehabilitation Source Type: research

Sturge-Weber Syndrome Type 3 in a 44 year old woman: A Case report & review of literature (P4.183)
Conclusions:SWS Type 3 consists of leptomeningeal angioma only, which can make the diagnosis challenging. Patients with SWS Type 3 may present in adulthood with primary neurologic symptoms of seizure, headache, behavioral problems or stroke-like symptoms. MRI brain remains the investigation of choice. Accurate diagnosis is essential in order to provide appropriate treatment, which includes aspirin and anti-epileptic agents, and avoid other unnecessary investigations.Disclosure: Dr. Lowe has nothing to disclose. Dr. Bhan has nothing to disclose. Dr. Rai, MD has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lowe, J., Bhan, C., Rai, V. Tags: Child Neurology II Source Type: research

Language, meaning, and localization: Last year's words, next year's words
Neurologic practice is deeply rooted in the ideal of localization. Some would argue that neurology arose in the mid-18th century from the study of language localization, regarded as a uniquely human function. The classic aphasias, those described by Broca and Wernicke, were believed to represent exemplars of lesion-symptom mapping, but many features of language-onset dementias went unexplained by conventional aphasiology.2 The description of aphasia syndromes in neurodegenerative diseases has largely overturned the static conceptualization of a brain language postcode.3 While incremental and cumulative, these neural networ...
Source: Neurology - March 5, 2017 Category: Neurology Authors: Brodtmann, A., Vogel, A. P. Tags: MRI, All Cerebrovascular disease/Stroke, Aphasia, Cortical localization EDITORIALS Source Type: research

Lesion localization of speech comprehension deficits in chronic aphasia
Conclusions: Damage to the mid-to-posterior MTG is associated with an inability to integrate multiword utterances during comprehension of spoken language. Impairment of this integration process likely underlies the speech comprehension deficits characteristic of Wernicke aphasia.
Source: Neurology - March 5, 2017 Category: Neurology Authors: Pillay, S. B., Binder, J. R., Humphries, C., Gross, W. L., Book, D. S. Tags: MRI, All Cerebrovascular disease/Stroke, Aphasia, Cortical localization ARTICLE Source Type: research

Effect of aphasia on acute stroke outcomes
Conclusion: Aphasia is independently associated with increased LOS and complications during the acute stroke admission, adding $2.16 billion annually to US acute stroke care. The presence of aphasia was more likely to produce a poor functional outcome than hemiparesis. These data suggest that further research is necessary to determine whether establishing adaptive communication skills can mitigate its consequences in the acute stroke setting.
Source: Neurology - November 27, 2016 Category: Neurology Authors: Boehme, A. K., Martin-Schild, S., Marshall, R. S., Lazar, R. M. Tags: All Clinical Neurology, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

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