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Effect and safety of C7 neurotomy at the intervertebral foramen in patients with chronic poststroke aphasia: a multicentre, randomised, controlled study protocol
This study will explore the efficacy of NC7 at the intervertebral foramen for improving chronic poststroke aphasia. Methods and analysis This study protocol reports a multicentre, randomised, assessor-blinded active-controlled trial. A total of 50 patients with chronic poststroke aphasia for over 1 year and with a aphasia quotient calculated by Western Aphasia Battery Aphasia Quotient (WAB-AQ) score below 93.8 will be recruited. Participants will be randomly assigned to 1 of 2 groups (25 individuals each) to receive NC7 plus intensive speech and language therapy (iSLT), or iSLT alone programme. The primary outcome is the ...
Source: BMJ Open - May 2, 2023 Category: General Medicine Authors: Li, T., Feng, J., Hu, R., Lv, M., Chang, W., Ma, X., Qi, W., Zhang, Y., Chen, X., Ding, L., Gu, Y., Xu, W. Tags: Open access, Neurology Source Type: research

Using experience-based codesign to coproduce aphasia rehabilitation services: study protocol
We present a protocol for the development of coproduced aphasia service elements. We will use experience-based codesign (EBCD), an approach that enables service users and providers to collaboratively develop services and care pathways. Drawing on the experiences of people with aphasia, their families and clinicians we will establish priorities for the development of new services and later work together to codesign them. Methods and analysis This research will be coproduced with people with aphasia (n=30–60), their families (n=30–60) and speech pathologists (n=30–60) in Queensland, Australia, using EBCD. ...
Source: BMJ Open - November 18, 2021 Category: General Medicine Authors: Anemaat, L., Palmer, V. J., Copland, D. A., Mainstone, K., Druery, K., Druery, J., Aisthorpe, B., Binge, G., Mainstone, P., Wallace, S. J. Tags: Open access, Rehabilitation medicine Source Type: research

Transcranial direct current stimulation (tDCS) for improving aphasia in adults with aphasia after stroke.
CONCLUSIONS: Currently there is no evidence of the effectiveness of tDCS (anodal tDCS, cathodal tDCS and Dual-tDCS) versus control (sham tDCS) for improving functional communication in people with aphasia after stroke (low quality of evidence). However, there is limited evidence that tDCS may improve naming performance in naming nouns (moderate quality of evidence), but not verbs (very low quality of evidence) at the end of the intervention period and possibly also at follow-up. Further methodologically rigorous RCTs with adequate sample size calculation are needed in this area to determine the effectiveness of this interv...
Source: Cochrane Database of Systematic Reviews - May 20, 2019 Category: General Medicine Authors: Elsner B, Kugler J, Pohl M, Mehrholz J Tags: Cochrane Database Syst Rev Source Type: research

Robot-Assisted Therapy in Upper Extremity Hemiparesis: Overview of an Evidence-Based Approach
Conclusion Robotic therapy has matured and represents an embodiment of a paradigm shift in neurorehabilitation following a stroke: instead of focusing on compensation, it affords focus in ameliorating the impaired limb in line with concepts of neuroplasticity. This technology-based treatment provides intensity, interactivity, flexibility, and adaptiveness to patient's performance and needs. Furthermore, it increases the productivity of rehabilitation care. Of course, efficiency must be discussed within a local perspective. For example, following the cost containment shown in the VA ROBOTICS study (46), the UK Nati...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Music interventions for acquired brain injury.
CONCLUSIONS: Music interventions may be beneficial for gait, the timing of upper extremity function, communication outcomes, and quality of life after stroke. These results are encouraging, but more high-quality randomised controlled trials are needed on all outcomes before recommendations can be made for clinical practice. PMID: 28103638 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 19, 2017 Category: Journals (General) Authors: Magee WL, Clark I, Tamplin J, Bradt J Tags: Cochrane Database Syst Rev Source Type: research

Tau Imaging Among Breakthroughs Advancing the Fight against Alzheimer ' s
Worldwide,  nearly44 million  people now have Alzheimer ' s disease (AD) or related dementia, making these conditions the  top cause of disabilities in later life. The biopharma industry has invested billions of dollars into research to treat and prevent AD1, yet this work has faced many obstacles, including difficulty identifying biomarkers, tracking the disease ’s progress in the brain, and recruiting patients to trials while they are still asymptomatic. But in recent years, we’ve begun to see breakthroughs that is driving our research in new directions. Many of these accomplishments were highlighted at the Alzh...
Source: EyeForPharma - September 21, 2016 Category: Pharmaceuticals Authors: Olga Uspenskaya-Cadoz Source Type: news

Clinical Updates, Tips on Business and Billing, Draw Attendees to ASHA Connect
Editor’s note: This is the first of two posts from the ongoing ASHA Connect Conference in Minneapolis. This post focuses on the health care side of the conference. The second, to come on Monday, will focus on the schools side. For speech-language pathologists in private practice and health care, attending ASHA Connect is a slam-dunk: The sessions give them hands-on information they can use right away. The sessions—smaller and more in-depth than those at the ASHA Annual Convention held in November—offer specific clinical strategies and business tips, attendees say. This is the first year for ASHA Connect, which began...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - July 8, 2016 Category: Speech Therapy Authors: Carol Polovoy Tags: Events Speech-Language Pathology Uncategorized Health Care Source Type: blogs

Transcranial direct current stimulation (tDCS) for improving aphasia in patients with aphasia after stroke.
CONCLUSIONS: Currently there is no evidence of the effectiveness of tDCS (anodal tDCS, cathodal tDCS and bihemispheric tDCS) versus control (sham tDCS) for improving functional communication, language impairment and cognition in people with aphasia after stroke. Further RCTs are needed in this area to determine the effectiveness of this intervention. Authors of future research should adhere to the CONSORT Statement. PMID: 25929694 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 1, 2015 Category: Journals (General) Authors: Elsner B, Kugler J, Pohl M, Mehrholz J Tags: Cochrane Database Syst Rev Source Type: research

Transcranial direct current stimulation (tDCS) for improving aphasia in patients after stroke.
CONCLUSIONS: Currently there is no evidence of the effectiveness of tDCS (anodal tDCS, cathodal tDCS) versus control (sham tDCS). However, it appears that cathodal tDCS over the non-lesioned hemisphere might be the most promising approach. PMID: 23799617 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 25, 2013 Category: Journals (General) Authors: Elsner B, Kugler J, Pohl M, Mehrholz J Tags: Cochrane Database Syst Rev Source Type: research

Survivor gives us a lens into regional systems of care for acute ischemic stroke in North Dakota
I just got back from the North Dakota Mission: Lifeline STEMI and Acute Stroke Conference in Bismark, ND. I had a great time and I learned a lot. I often get asked to speak in various venues about acute STEMI and 12-lead ECG interpretation, but for this conference they wanted me to talk mostly about stroke. That turned out to be a good thing because it forced me to read the 2013 AHA / ASA Guildelines for the Early Management of Patients With Acute Ischemic Stroke to make sure I was asking intelligent questions during the panel discussion (which I moderated) and also giving accurate information for the class I taught about ...
Source: EMS 12-Lead - May 31, 2013 Category: Cardiology Authors: Tom Bouthillet Tags: ems-topics patient-management North Dakota Mission Lifeline Stroke Source Type: research

Researchers bring hope for patients with aphasia
Two groups of researchers have presented preliminary results of studies aiming to help in the treatment of aphasia at the conference of the American Association for the Advancement of Science in Boston, Massachusetts, USA, this month.
Source: MedWire News - Stroke - February 28, 2013 Category: Neurology Source Type: news