Robot-Assisted Therapy in Upper Extremity Hemiparesis: Overview of an Evidence-Based Approach

Robot-Assisted Therapy in Upper Extremity Hemiparesis: Overview of an Evidence-Based Approach Christophe Duret1,2*, Anne-Gaëlle Grosmaire1 and Hermano Igo Krebs3,4,5,6,7,8 1Centre de Rééducation Fonctionnelle Les Trois Soleils, Médecine Physique et de Réadaptation, Unité de Neurorééducation, Boissise-Le-Roi, France 2Centre Hospitalier Sud Francilien, Neurologie, Corbeil-Essonnes, France 3Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States 4Department of Neurology, University of Maryland, Baltimore, MD, United States 5Department of Physical Medicine and Rehabilitation, Fujita Health University, Nagoya, Japan 6Institute of Neuroscience, University of Newcastle, Newcastle upon Tyne, United Kingdom 7Department of Mechanical Sciences and Bioengineering, Osaka University, Osaka, Japan 8Wolfson School of Mechanical, Electrical, and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom Robot-mediated therapy is an innovative form of rehabilitation that enables highly repetitive, intensive, adaptive, and quantifiable physical training. It has been increasingly used to restore loss of motor function, mainly in stroke survivors suffering from an upper limb paresis. Multiple studies collated in a growing number of review articles showed the positive effects on motor impairment, less clearly on functional limitations. After describing the c...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Increased rates of locoregional recurrence are observed in patients with basal-like breast cancer (BC) despite the use of radiation therapy (RT); therefore, approaches that result in radiosensitization of basal-like BC are critically needed. Using patients’ tumor gene expression data from 4 independent data sets, we correlated gene expression with recurrence to find genes significantly correlated with early recurrence after RT. The highest-ranked gene, TTK, was most highly expressed in basal-like BC across multiple data sets. Inhibition of TTK by both genetic and pharmacologic methods enhanced radiosensitivity in mul...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although the underlying molecular mechanisms remain under investigation. Here we demonstrated that endothelial genetic deletion, using EphA4fl/fl/Tie2-Cre and EphA4fl/fl/VeCahderin-CreERT2 mice and vessel painting strategies, implicated EphA4 receptor tyrosine kinase as a major suppressor of pial collateral remodeling, CBF, and functional recovery following permanent middle cerebral artery occ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSION We identified a population of HCV-specific CD4+ T cells with a follicular T helper cell signature that is maintained after therapy-induced elimination of persistent infection and may constitute an important target population for vaccination efforts to prevent reinfection and immunotherapeutic approaches for persistent viral infections.FUNDING Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), the National Institute of Allergy and Infectious Diseases (NIAID), the European Union, the Berta-Ottenstein-Programme for Advanced Clinician Scientists, and the ANRS.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: 15 May 2020Source: Journal of Alloys and Compounds, Volume 823Author(s): Jinzhi Jia, Xu Dong Liu, Xiaojia Li, Linhong Cao, Meng Zhang, Botao Wu, Xiuwen ZhouAbstractThe morphology and size of nanostructures have been considered to be directly related to capacitive performance. Additionally, hydrothermal synthesis is a common method to control nanostructures. In practice, researchers paid more attention to the direct effect of “useful ions” on morphology or size of nanostructures, e.g. the combination and decomposition processes of H+ and WO42− to form WO3. Unfortunately, the effects of ot...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: 15 May 2020Source: Journal of Alloys and Compounds, Volume 823Author(s): Stephan Laube, Hans Chen, Alexander Kauffmann, Steven Schellert, Franz Müller, Bronislava Gorr, Julian Müller, Benjamin Butz, Hans-Juergen Christ, Martin HeilmaierAbstractRefractory high entropy alloys (RHEAs) from the Mo–Cr–Ti–Al system exhibit promising strength at elevated temperatures. However, at room temperature they possess a B2-ordered crystal structure and, therefore, exhibit reduced ductility. Guided by thermodynamic calculations, the Al concentration was systematically reduced in MoCrTi-xAl (x&n...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Letter of Intent Deadline Date: February 21, 2020 Program Guidelines: NSF 20-530NSF solicits proposals to manage the operations and maintenance of the National Ecological Observatory Network (NEON), an NSF-funded major facility project.  NEON comprises terrestrial, aquatic, atmospheric, and remote sensing measurement infrastructure and cyberinfrastructure that deliver standardized, calibrated data to the scientific community through a single, openly accessible data portal.  NEON infrastructure is geographically distributed across the United States, ...More at https://www.nsf.gov/funding/pgm_summ.jsp?pim...
Source: NSF Upcoming Due Dates - Category: Science Source Type: funding
Recent years have witnessed the proliferation of victim-focused positions inside and outside the criminal justice system, yet little is known about the occupational characteristics and organizational context of this field in the United States. In this arti...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
This study derives and validates up-to-date comorbidity indices for hospital-admitted injury patients, specific to mortality outcomes. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Authors: Ertel KA, Hallam JE, Hillman AR Abstract BACKGROUND: Individuals participating in exercise beyond their level of fitness may be at higher risk for exercise-induced muscle damage, however the impact of training status on muscle damage development is not well understood. The purpose of this study was to measure skeletal muscle damage and soreness after five days of high and low intensity exercise in previously trained and untrained individuals. METHODS: Eighteen males and females (9 trained and 9 untrained) completed five consecutive days of high intensity (HI) exercise and five consecutive days of low i...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
This study aimed to highlight trends in treatment patterns and comorbidities using up to date longitudinal patient related data from Germany.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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