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Upper limb arterial thromboembolism: A systematic review on incidence, risk factors, and prognosis including a meta‐analysis of risk‐modifying drugs
ConclusionsAge, female sex, AF, hypertension, diabetes, myocardial infarction, heart failure and stroke are most common risk factors for thromboembolectomy of the upper limb. The availability of NOAC holds promise in reducing the risk of systemic thromboembolism, but specific data are still limited.© 2013 International Society on Thrombosis and Haemostasis
Source: Journal of Thrombosis and Haemostasis - February 25, 2013 Category: Hematology Authors: L V. Andersen, G Y.H. Lip, J S. Lindholt, L Frost Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

SMC accepts apixaban (Eliquis®) for prevention of stroke and systemic embolism in adults with AF
Source: Scottish Medicines Consortium (SMC) Area: Evidence > Drug Specific Reviews The Scottish Medicines Consortium has accepted apixaban (Eliquis®) for use within NHS Scotland for the prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA); age ?75 years; hypertension; diabetes mellitus; symptomatic heart failure (NYHA class ?II).   The Detailed Advice accompanying the recommendation (see link below) summarises the evidence on efficacy and safety, the clinical effective...
Source: NeLM - Cardiovascular Medicine - February 11, 2013 Category: Cardiology Source Type: news

Effect of Age on Treatment, Trends and Outcome of Patients Hospitalized With Atrial Fibrillation: Insights From a 20-Years Registry in a Middle-eastern Country (1991-2010).
Conclusion: Anticoagulation remains underutilized in elderly patients with AF despite proven efficacy and increasing trends of cardiovascular comorbidities. The current study underscores the urgent need for prospective studies to investigate warfarin contraindications, relative warfarin efficacy and bleeding risks in our region to help guide healthcare providers in warfarin prescribing in this frail patient population and consequently reduce the risk of AF-related disabling strokes and mortality. PMID: 23211770 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - November 26, 2012 Category: Geriatrics Authors: Salam AM, Albinali HA, Al-Sulaiti EM, Al-Mulla AW, Singh R, Al Suwaidi J Tags: Aging Clin Exp Res Source Type: research

The impact of CHADS2 score on late stroke after the Cox maze procedure
Conclusions: The risk of stroke or transient ischemic attack in patients after a surgical Cox maze procedure was low and not associated with CHADS2 score or warfarin use. Given the known risks of warfarin, we recommend discontinuation of anticoagulation 3 months after the procedure if the patient has no evidence of atrial fibrillation, has discontinued antiarrhythmic medications, and is without any other indication for systemic anticoagulation.
Source: The Journal of Thoracic and Cardiovascular Surgery - July 23, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Mitchell Pet, Jason O. Robertson, Marci Bailey, Tracey J. Guthrie, Marc R. Moon, Jennifer S. Lawton, Andrew Rinne, Ralph J. Damiano, Hersh S. Maniar Tags: Acquired Cardiovascular Disease Source Type: research

Identifying a High Stroke Risk Subgroup in Individuals with Heart Failure
Conclusions: The combination of previous stroke/TIA and DM increases the incidence of stroke in participants with HF without AF. No analyzed subgroup had a stroke rate high enough to make it likely that the benefits of warfarin would outweigh the risks.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2011 Category: Neurology Authors: Patrick M. Pullicino, Leslie A. McClure, Virginia J. Howard, Virginia G. Wadley, Monika M. Safford, James F. Meschia, Aaron Anderson, George Howard, Elsayed Z. Soliman Tags: Original Articles Source Type: research

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