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Source: Stroke
Condition: Dementia
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Total 84 results found since Jan 2013.
Texture Analysis of T1-Weighted and Fluid-Attenuated Inversion Recovery Images Detects Abnormalities That Correlate With Cognitive Decline in Small Vessel Disease Clinical Sciences
Conclusions—TP, which can be obtained from routine clinical images, are abnormal in SVD, and the degree of abnormality correlates with executive dysfunction and global cognition at baseline and decline during 5 years. TP may be useful to assess disease severity in clinically collected data. This needs testing in data clinically acquired across multiple sites.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Daniel J. Tozer, Eva Zeestraten, Andrew J. Lawrence, Thomas R. Barrick, Hugh S. Markus Tags: Imaging, Magnetic Resonance Imaging (MRI), Vascular Disease Original Contributions Source Type: research
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia Clinical Sciences
Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Daniel J. Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Progression of White Matter Hyperintensities Preceded by Heterogeneous Decline of Microstructural Integrity Clinical Sciences
Conclusions—Impaired microstructural integrity preceded conversion into WMH and continuously declined over time, suggesting a continuous disease process of white matter integrity loss that can be detected using diffusion tensor imaging even years before WMH become visible on conventional neuroimaging. Differences in microstructural integrity between participants with mild versus severe WMH suggest heterogeneity of both NAWM and WMH, which might explain the clinical variability observed in patients with similar small vessel disease severity.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Esther M.C. van Leijsen, Mayra I. Bergkamp, Ingeborg W.M. van Uden, Mohsen Ghafoorian, Helena M. van der Holst, David G. Norris, Bram Platel, Anil M. Tuladhar, Frank-Erik de Leeuw Tags: Etiology, Cardiovascular Disease, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Vascular Disease Original Contributions Source Type: research
Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit Clinical Sciences
Conclusions—This study is the first to have optimized the operationalization of the criterion for poststroke cognitive impairment. It documented the prevalence of poststroke NCD in the GRECOG-VASC cohort and showed that mild cognitive impairment accounts for 80% of the affected patients. Finally, the method developed in the present study offers a means of harmonizing the diagnosis of NCD.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT01339195.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Melanie Barbay, Herve Taillia, Claudine Nedelec–Ciceri, Flavie Bompaire, Camille Bonnin, Jerome Varvat, Francoise Grangette, Momar Diouf, Emmanuel Wiener, Jean–Louis Mas, Martine Roussel, Olivier Godefroy Tags: Cognitive Impairment Original Contributions Source Type: research
Arterial Stiffness Is Associated With Basal Ganglia Enlarged Perivascular Spaces and Cerebral Small Vessel Disease Load Brief Report
Conclusions—We found that, in a cohort of hypertensive individuals, the arterial stiffness is associated with the total load of the cSVD, especially with lacunes and basal ganglia EPVS.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Iolanda Riba–Llena, Joan Jimenez–Balado, Xavier Castane, Anna Girona, Antonio Lopez–Rueda, Xavier Mundet, Carmen I. Jarca, Jose Alvarez–Sabin, Joan Montaner, Pilar Delgado Tags: Hypertension Brief Reports Source Type: research
Plasma A{beta} (Amyloid-{beta}) Levels and Severity and Progression of Small Vessel Disease Clinical Sciences
Background and Purpose—Cerebral small vessel disease (SVD) is a frequent pathology in aging and contributor to the development of dementia. Plasma Aβ (amyloid β) levels may be useful as early biomarker, but the role of plasma Aβ in SVD remains to be elucidated. We investigated the association of plasma Aβ levels with severity and progression of SVD markers.Methods—We studied 487 participants from the RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort) of whom 258 participants underwent 3 MRI assessments during 9 years. We determined baseline plasma Aβ38, Aβ40, and AÎ...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Esther M.C. van Leijsen, H. Bea Kuiperij, Iris Kersten, Mayra I. Bergkamp, Ingeborg W.M. van Uden, Hugo Vanderstichele, Erik Stoops, Jurgen A.H.R. Claassen, Ewoud J. van Dijk, Frank-Erik de Leeuw, Marcel M. Verbeek Tags: Biomarkers, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities Clinical Sciences
Conclusions—Larger cIMT was associated with greater burden of cerebral WM lesions independently of demographics and traditional vascular risk factors, particularly among elderly and Hispanic participants, who are at high risk for stroke and cognitive decline.
Source: Stroke - January 22, 2018 Category: Neurology Authors: David Della-Morte, Chuanhui Dong, Matthew S. Markert, Mitchell S.V. Elkind, Ralph L. Sacco, Clinton B. Wright, Tatjana Rundek Tags: Epidemiology, Race and Ethnicity, Ultrasound Original Contributions Source Type: research
Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Executive Function Declines in the First 6 Months After a Transient Ischemic Attack or Transient Neurological Attack Clinical Sciences
Conclusions—Executive function declines during the first 6 months after TIA or TNA. Patients with an initial DWI lesion have persisting worse executive function than those without.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Frank G. van Rooiȷ, Nicole O. Plaizier, Sarah E. Vermeer, Bozena M. Goraȷ, Peter J. Koudstaal, Edo Richard, Frank–Erik de Leeuw, Roy P.C. Kessels, Ewoud J. van Diȷk Tags: Cognitive Impairment, Transient Ischemic Attack (TIA) Original Contributions Source Type: research
Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke Clinical Sciences
Background and Purpose—Assessment of cognitive status poststroke is recommended by guidelines but follow-up can often not be done in person. The Telephone Interview of Cognitive Status (TICS) and the Telephone Montreal Cognitive Assessment (T-MoCA) are considered useful screening instruments. Yet, evidence to define optimal cut-offs for mild cognitive impairment (MCI) after stroke is limited.Methods—We studied 105 patients enrolled in the prospective DEDEMAS study (Determinants of Dementia After Stroke; NCT01334749). Follow-up visits at 6, 12, 36, and 60 months included comprehensive neuropsychological testing and the ...
Source: Stroke - October 23, 2017 Category: Neurology Authors: Vera Zietemann, Anna Kopczak, Claudia Muller, Frank Arne Wollenweber, Martin Dichgans Tags: Clinical Studies, Cognitive Impairment Original Contributions Source Type: research
Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association AHA/ASA Presidential Advisory
Cognitive function is an important component of aging and predicts quality of life, functional independence, and risk of institutionalization. Advances in our understanding of the role of cardiovascular risks have shown them to be closely associated with cognitive impairment and dementia. Because many cardiovascular risks are modifiable, it may be possible to maintain brain health and to prevent dementia in later life. The purpose of this American Heart Association (AHA)/American Stroke Association presidential advisory is to provide an initial definition of optimal brain health in adults and guidance on how to maintain br...
Source: Stroke - September 25, 2017 Category: Neurology Authors: Philip B. Gorelick, Karen L. Furie, Costantino Iadecola, Eric E. Smith, Salina P. Waddy, Donald M. Lloyd-Jones, Hee-Joon Bae, Mary Ann Bauman, Martin Dichgans, Pamela W. Duncan, Meighan Girgus, Virginia J. Howard, Ronald M. Lazar, Sudha Seshadri, Fernando Tags: Statements and Guidelines AHA/ASA Presidential Advisory Source Type: research
Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia Clinical Sciences
Conclusions—Our data suggest that some degree of blood–brain barrier dysfunction is common in older people and that this may be related to clinical dementia risk, additional to standard MRI biomarkers.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Atticus H. Hainsworth, Thais Minett, Joycelyn Andoh, Gillian Forster, Ishaan Bhide, Thomas R. Barrick, Kay Elderfield, Jamuna Jeevahan, Hugh S. Markus, Leslie R. Bridges Tags: Blood-Brain Barrier, Cognitive Impairment, Vascular Disease Original Contributions Source Type: research
Letter by Fenton and Bellman Regarding Article, “Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study” Letter to the Editor
Source: Stroke - August 28, 2017 Category: Neurology Authors: Tanis Fenton, Jane Bellman Tags: Diet and Nutrition Letters to the Editor Source Type: research
Response by Pase et al to Letter Regarding Article, “Sweetened Beverages and the Risks of Incident Stroke and Dementia” Letter to the Editor
Source: Stroke - August 28, 2017 Category: Neurology Authors: Matthew P. Pase, Jayandra J. Himali, Sudha Seshadri, Paul F. Jacques Tags: Diet and Nutrition, Epidemiology, Risk Factors, Ischemic Stroke Letters to the Editor Source Type: research
Correction to: Effect of Long-Term Vascular Care on Progression of Cerebrovascular Lesions: Magnetic Resonance Imaging Substudy of the PreDIVA Trial (Prevention of Dementia by Intensive Vascular Care) Correction
Source: Stroke - August 28, 2017 Category: Neurology Tags: Corrections Source Type: research
