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Montreal Cognitive Assessment 5-Minute Protocol Is a Brief, Valid, Reliable, and Feasible Cognitive Screen for Telephone Administration Clinical Sciences
Conclusions— The MoCA 5-minute protocol is a free, valid, and reliable cognitive screen for stroke and transient ischemic attack. It is brief and highly feasible for telephone administration.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Wong, A., Nyenhuis, D., Black, S. E., Law, L. S. N., Lo, E. S. K., Kwan, P. W. L., Au, L., Chan, A. Y. Y., Wong, L. K. S., Nasreddine, Z., Mok, V. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Association of White Matter Integrity and Cognitive Functions in Patients With Subcortical Silent Lacunar Infarcts Brief Reports
Conclusions— SLI in basal ganglia leads to local and remote white matter integrity damages and to the cognition impairments.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Chen, Y., Wang, A., Tang, J., Wei, D., Li, P., Chen, K., Wang, Y., Zhang, Z. Tags: Behavioral Changes and Stroke, Other imaging Brief Reports Source Type: research

Progressive Cognitive Deficits in a Mouse Model of Recurrent Photothrombotic Stroke Brief Reports
Conclusions— Our results show progressive cognitive deficits in a mouse model of recurrent photothrombotic stroke. The presented model resembles the clinical features of human multi-infarct dementia and enables the investigation of its pathophysiological mechanisms and the evaluation of treatment strategies.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Schmidt, A., Diederich, K., Strecker, J.-K., Geng, B., Hoppen, M., Duning, T., Schabitz, W.-R., Minnerup, J. Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro Clinical Sciences
Conclusions— Our findings support the view that cysteine-sparing mutations, such as D80G, might cause CADASIL with a phenotype largely indistinguishable from cysteine mutations. The in vitro aggregation analysis of atypical NOTCH3 mutations offers novel insights into pathomechanisms and might represent a tool for estimating their clinical significance.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Wollenweber, F. A., Hanecker, P., Bayer-Karpinska, A., Malik, R., Bazner, H., Moreton, F., Muir, K. W., Muller, S., Giese, A., Opherk, C., Dichgans, M., Haffner, C., Duering, M. Tags: Clinical genetics, Cerebrovascular disease/stroke, Other diagnostic testing, Other Vascular biology Clinical Sciences Source Type: research

Methodological Factors in Determining Rates of Dementia in Transient Ischemic Attack and Stroke: (I) Impact of Baseline Selection Bias Clinical Sciences
Conclusions— Exclusion of patients unavailable for assessment, and other widely used selection criteria, results in underestimation of the measured rate of dementia associated with transient ischemic attack and stroke.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Pendlebury, S. T., Chen, P.-J., Bull, L., Silver, L., Mehta, Z., Rothwell, P. M., for the Oxford Vascular Study Tags: Behavioral Changes and Stroke Clinical Sciences Source Type: research

Genes From a Translational Analysis Support a Multifactorial Nature of White Matter Hyperintensities Clinical Sciences
Conclusions— Despite not passing multiple testing thresholds individually, these genes collectively are relevant to known WMH associations, proposed WMH mechanisms, or dementia: associations with Alzheimer's disease, late-life depression, ATP production, osmotic regulation, neurodevelopmental abnormalities, and cognitive impairment. If replicated further, they suggest a multifactorial nature for WMH and argue for more consideration of vascular contributions to dementia.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Lopez, L. M., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz Maniega, S., Bastin, M. E., Bailey, E., Smith, C., McBride, M., McClure, J., Graham, D., Dominiczak, A., Yang, Q., Fornage, M., Ikram, M. A., Debette, S., Launer, L., Bis, J. C., Schmid Tags: Other Vascular biology Clinical Sciences Source Type: research

Influence of Intracerebral Hemorrhage Location on Incidence, Characteristics, and Outcome: Population-Based Study Clinical Sciences
Conclusions— The baseline characteristics and outcome of lobar ICH differ from other locations.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Samarasekera, N., Fonville, A., Lerpiniere, C., Farrall, A. J., Wardlaw, J. M., White, P. M., Smith, C., Al-Shahi Salman, R., for the Lothian Audit of the Treatment of Cerebral Haemorrhage Collaborators, Addison, Ahmad, Alhadad, Andrews, Bisset, Bodkin, B Tags: Acute Cerebral Hemorrhage Clinical Sciences Source Type: research

Relationship Between White Matter Hyperintensities, Cortical Thickness, and Cognition Clinical Sciences
Conclusions— These cross-sectional results suggest that cortical changes (regional-specific damage and network breakdown), mediated (in)directly by WMH (tract-specific damage) and other factors (eg, vascular risk factors), might lead to cognitive decline. These findings have implications in understanding the relationship between WMH, cortical morphology, and the possible attendant cognitive decline and eventually dementia.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Tuladhar, A. M., Reid, A. T., Shumskaya, E., de Laat, K. F., van Norden, A. G. W., van Dijk, E. J., Norris, D. G., de Leeuw, F.-E. Tags: Other imaging Clinical Sciences Source Type: research

Cortical Microinfarcts Detected In Vivo on 3 Tesla MRI: Clinical and Radiological Correlates Brief Reports
Conclusions— We found an association of CMIs with clinical parameters, including age and cardiovascular risk factors. Although the prevalence of CMIs is relatively low, our results suggest that the study of CMIs in larger clinical studies is possible using 3 Tesla MRI. This opens the possibility of large-scale prospective investigation of the clinical relevance of CMIs in older people.
Source: Stroke - December 22, 2014 Category: Neurology Authors: van Dalen, J. W., Scuric, E. E. M., van Veluw, S. J., Caan, M. W. A., Nederveen, A. J., Biessels, G. J., van Gool, W. A., Richard, E. Tags: Acute Cerebral Infarction, Cerebral Lacunes, Risk Factors for Stroke Brief Reports Source Type: research

White Matter Lesions Are Associated With Hospital Admissions Because of Hip-Fractures and Trauma After Ischemic Stroke Clinical Sciences
Conclusions— Patients with ischemic stroke and moderate-to-severe WMLs are at high risk, who experience serious traumatic injuries and especially hip-fractures requiring hospital treatment.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Sibolt, G., Curtze, S., Melkas, S., Pohjasvaara, T., Kaste, M., Karhunen, P. J., Oksala, N. K. J., Strandberg, T., Erkinjuntti, T. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Test Accuracy of Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke Clinical Sciences
Conclusions— Commonly used cognitive screening tools have similar accuracy for detection of dementia/multidomain impairment with no clearly superior test and no evidence that screening tools with longer administration times perform better. MoCA at usual threshold offers short assessment time with high sensitivity but at cost of specificity; adapted cutoffs have improved specificity without sacrificing sensitivity. Our results must be interpreted in the context of modest study numbers: heterogeneity and potential bias.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Lees, R., Selvarajah, J., Fenton, C., Pendlebury, S. T., Langhorne, P., Stott, D. J., Quinn, T. J. Tags: Behavioral/psychosocial - stroke, Other diagnostic testing, Behavioral Changes and Stroke Clinical Sciences Source Type: research

Association of Cognitive Functioning, Incident Stroke, and Mortality in Older Adults Clinical Sciences
Conclusions— Baseline cognitive function was associated with incident stroke. Cognitive decline increased significantly after stroke relative to before stroke. Cognitive decline increased mortality risk independent of the risk attributable to stroke and should be followed as a marker for both stroke and mortality.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Rajan, K. B., Aggarwal, N. T., Wilson, R. S., Everson-Rose, S. A., Evans, D. A. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Persistent Cognitive Impairment After Transient Ischemic Attack Clinical Sciences
Conclusions— More than a third of patients with TIA have impairment of ≥1 cognitive domain within 3 months after their TIA. The affected domains fit in the vascular cognitive impairment profile.
Source: Stroke - July 28, 2014 Category: Neurology Authors: van Rooij, F. G., Schaapsmeerders, P., Maaijwee, N. A. M., van Duijnhoven, D. A. H. J., de Leeuw, F.-E., Kessels, R. P. C., van Dijk, E. J. Tags: Behavioral/psychosocial - stroke, Behavioral Changes and Stroke, Transient Ischemic Attacks Clinical Sciences Source Type: research

Cortical Hubs and Subcortical Cholinergic Pathways as Neural Substrates of Poststroke Dementia Clinical Sciences
Conclusions— Disruption of cholinergic pathways and major hubs of large-scale neural networks might contribute to newly developed dementia after acute ischemic stroke.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Lim, J.-S., Kim, N., Jang, M. U., Han, M.-K., Kim, S., Baek, M. J., Jang, M. S., Ban, B., Kang, Y., Kim, D.-E., Lee, J. S., Lee, J., Lee, B.-C., Yu, K.-H., Black, S. E., Bae, H.-J. Tags: Behavioral/psychosocial - stroke, Behavioral Changes and Stroke Clinical Sciences Source Type: research

Systematic Review and Meta-Analysis of Interventions Tested in Animal Models of Lacunar Stroke Basic Sciences
Conclusions— No intervention has yet been tested in sufficient range and depth to support translation to clinical trial. There is limited reporting of measures to reduce the risk of bias and evidence for a substantial publications bias.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Pedder, H., Vesterinen, H. M., Macleod, M. R., Wardlaw, J. M. Tags: Acute Cerebral Infarction, Cerebral Lacunes, Emergency treatment of Stroke Basic Sciences Source Type: research

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