Plasma A{beta} (Amyloid-{beta}) Levels and Severity and Progression of Small Vessel Disease [Clinical Sciences]

Background and Purpose—Cerebral small vessel disease (SVD) is a frequent pathology in aging and contributor to the development of dementia. Plasma Aβ (amyloid β) levels may be useful as early biomarker, but the role of plasma Aβ in SVD remains to be elucidated. We investigated the association of plasma Aβ levels with severity and progression of SVD markers.Methods—We studied 487 participants from the RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort) of whom 258 participants underwent 3 MRI assessments during 9 years. We determined baseline plasma Aβ38, Aβ40, and Aβ42 levels using ELISAs. We longitudinally assessed volume of white matter hyperintensities semiautomatically and manually rated lacunes and microbleeds. We analyzed associations between plasma Aβ and SVD markers by ANCOVA adjusted for age, sex, and hypertension.Results—Cross-sectionally, plasma Aβ40 levels were elevated in participants with microbleeds (mean, 205.4 versus 186.4 pg/mL; P

Source: Stroke - March 26, 2018 Category: Neurology Authors: Esther M.C. van Leijsen, H. Bea Kuiperij, Iris Kersten, Mayra I. Bergkamp, Ingeborg W.M. van Uden, Hugo Vanderstichele, Erik Stoops, Jurgen A.H.R. Claassen, Ewoud J. van Dijk, Frank-Erik de Leeuw, Marcel M. Verbeek Tags: Biomarkers, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research