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Sneddon syndrome: a comprehensive clinical review of 53 patients
ConclusionsSS predominantly affects young women with a relatively large number of cardiovascular risk factors. Clinical features of SS are comparable across different studies. We found no differences in the main clinical features between APL-positive and APL-negative patients.
Source: Journal of Neurology - January 29, 2021 Category: Neurology Source Type: research

Mechanisms of kidney disease in Sneddon's syndrome: Case report and literature review 
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We report a case of Sneddon's syndrome with chronic kidney disease, associated with features of endarteritis obliterans in the skin and the kidney. The clinical presentation of our patient is compared to previously reported cases of Sneddon's syndrome with biopsy-proven kidney disease. We also discuss the differential diagnosis, pathophysiological mechanisms, relationship with antiphospholipid syndrome, and management of patients with Sneddon's syndrome and kidney disease. This clinical observation supports the systemic nature of Sneddon's syndrome and provides insights into the mechanisms by which this rare but probably u...
Source: Clinical Nephrology - October 28, 2019 Category: Urology & Nephrology Authors: Ghislain L, Aydin S, Marot L, Demoulin N, Morelle J Tags: Clin Nephrol Source Type: research

Sneddon's syndrome: it is all in the ectoderm.
Abstract A 51-year-old man gave a 2-year history of worsening mobility, cognitive decline and headaches. He had a history of thromboembolic stroke, recurrent transient ischaemic attacks and a spontaneous intraventricular haemorrhage. On examination, he had livedo reticularis and perniosis and a systolic murmur. Catheter cerebral angiography showed peripheral small-vessel and medium-vessel vasculopathy resulting in pruning of the distal cortical vessels and tortuous irregular distal collaterals. Skin biopsy showed subtle vasculopathy with ectasia of capillaries and postcapillary venules but no frank vasculitis or a...
Source: Practical Neurology - March 11, 2016 Category: Neurology Authors: Rutter-Locher Z, Chen Z, Flores L, Basu T, Creamer D, Weeks R, Arya R, Nashef L Tags: Pract Neurol Source Type: research

Cardiac manifestations of Sneddon's syndrome
Sneddon's syndrome (SS) is rare, non-inflammatory arteriopathy characterized by cerebrovascular disease and livedo reticularis (LR). It generally affects women between 20 and 42years of age [1], so this entity is increasingly recognized as a cause of stroke in young adults [2]. The pathophysiology of SS is not fully understood, but the presence of antiphospholipid antibodies in 50% of patients [3], as well as the skin and brain biopsy findings, suggests a thrombotic vasculopathy of medium and small arteries.
Source: International Journal of Cardiology - April 21, 2015 Category: Cardiology Authors: Fernando Dominguez, Burkert Pieske, Sebastian Kelle Tags: Letter to the editor Source Type: research

Cardiac manifestations of Sneddon´s syndrome
Sneddon's syndrome (SS) is rare, non-inflammatory arteriopathy characterized by cerebrovascular disease and livedo reticularis (LR). It generally affects women between 20 and 42years of age [1], so this entity is increasingly recognised as a cause of stroke in young adults [2]. The pathophysiology of SS is not fully understood, but the presence of antiphospholipid antibodies in 50% of patients [3], as well as the skin and brain biopsy findings, suggest a thrombotic vasculopathy of medium and small arteries.
Source: International Journal of Cardiology - April 21, 2015 Category: Cardiology Authors: Fernando Dominguez, Burkert Pieske, Sebastian Kelle Tags: Letter to the Editor Source Type: research