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Specialty: Cardiology
Condition: Diabetes Type 2

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Total 574 results found since Jan 2013.

Circulating Endothelial Progenitor and Mesenchymal Stromal Cells as Biomarkers for Monitoring Disease Status and Responses to Exercise
Rev Cardiovasc Med. 2022 Dec 2;23(12):396. doi: 10.31083/j.rcm2312396.ABSTRACTNoncommunicable chronic diseases, such as obesity, cardiovascular disease (CVD), and type 2 diabetes (T2D), pose significant health challenges globally. Important advances have been made in the understanding of the pathophysiologal mechanisms and treatment of noncommunicable diseases in recent years. Lack of physical activity is a primary contributor to many noncommunicable diseases including metabolic syndrome, T2D, CVD, and obesity. Certain diabetes medications and non-pharmaceutical interventions, such as physical activity and exercise, are sh...
Source: Reviews in Cardiovascular Medicine - September 8, 2023 Category: Cardiology Authors: Jared M Gollie Sabyasachi Sen Source Type: research

Long-term efficacy and safety of early alogliptin initiation in subjects with type 2 diabetes: an extension of the SPEAD-A study
Sci Rep. 2023 Sep 5;13(1):14649. doi: 10.1038/s41598-023-41036-1.ABSTRACTWe previously reported in the study of preventive effects of alogliptin on diabetic atherosclerosis (SPEAD-A) that alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, attenuated the progression of carotid atherosclerosis in subjects with type 2 diabetes and no history of cardiovascular disease. This extension study of the SPEAD-A trial investigated whether early alogliptin initiation improved long-term cardiovascular outcomes. The SPEAD-A trial randomized 341 subjects with type 2 diabetes to either alogliptin or conventional treatment to investiga...
Source: Atherosclerosis - September 5, 2023 Category: Cardiology Authors: Tomoya Mita Naoto Katakami Hidenori Yoshii Tomio Onuma Hideaki Kaneto Takeshi Osonoi Toshihiko Shiraiwa Tetsuyuki Yasuda Yutaka Umayahara Tsunehiko Yamamoto Hiroki Yokoyama Nobuichi Kuribayashi Hideaki Jinnouchi Masahiko Gosho Iichiro Shimomura Hirotaka W Source Type: research

Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events
CONCLUSIONS AND RELEVANCE: A protein risk score was significantly associated with ASCVD events in primary and secondary event populations. When added to clinical risk factors, the protein risk score and polygenic risk score both provided statistically significant but modest improvement in discrimination.PMID:37606673 | DOI:10.1001/jama.2023.13258
Source: Atherosclerosis - August 22, 2023 Category: Cardiology Authors: Hannes Helgason Thjodbjorg Eiriksdottir Magnus O Ulfarsson Abhishek Choudhary Sigrun H Lund Erna V Ivarsdottir Grimur Hjorleifsson Eldjarn Gudmundur Einarsson Egil Ferkingstad Kristjan H S Moore Narimon Honarpour Thomas Liu Huei Wang Thomas Hucko Marc S S Source Type: research

Sodium-Glucose Cotransporter-2 Inhibitors and Primary Prevention of Atherosclerotic Cardiovascular Disease: A Meta-Analysis of Randomized Trials and Systematic Review
Conclusions SGLT2 inhibitors significantly reduced atherosclerotic MACEs in subjects having both chronic kidney disease and type 2 diabetes without established ASCVD.PMID:37581396 | DOI:10.1161/JAHA.123.030578
Source: Atherosclerosis - August 15, 2023 Category: Cardiology Authors: Hammad Rahman Safi U Khan Ahmad N Lone Priyanka Ghosh Mahathi Kunduru Saurabh Sharma Sudhakar Sattur Edo Kaluski Source Type: research

Type 2 diabetes mellitus, atherosclerosis, and ischemic stroke: Histopathological changes of the brain
Background and Aims: Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including cerebrovascular disease. Atherosclerosis and ischemic stroke in diabetic patients occur 4 times more often than in the general population. Our aim was to investigate the brain tissue of patients with type 2 diabetes mellitus who died from ischemic stroke.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: L. Volos, T. Mykhaylichenko Source Type: research

Protective Effects of Different Classes, Intensity, Cumulative Dose-Dependent of Statins Against Primary Ischemic Stroke in Patients with Type 2 Diabetes Mellitus
AbstractPurpose of ReviewThe aim of this study is to investigate the protective effects of different statin classes, intensity, and cumulative dose-dependent against primary ischemic stroke in patients with T2DM.Recent FindingsThe Cox hazards model was used to evaluate statin use on primary ischemic stroke. Case group: T2DM patients who received statins; control group: T2DM patients who received no statins during the follow-up. Adjusted hazard ratio (aHR) for primary ischemic stroke was 0.45 (95% CI: 0.44 to 0.46). Cox regression analysis showed significant reductions in primary ischemic stroke incidence in users of differ...
Source: Current Atherosclerosis Reports - July 29, 2023 Category: Cardiology Source Type: research

Elevated plasma factor XI predicts cardiovascular events in patients with type 2 diabetes: a long-term observational study
Type 2 diabetes mellitus (T2DM) patients are at high risk of cardiovascular (CV) events. Factor XI (FXI) is associated with arterial thromboembolism, including myocardial infarction (MI), stroke, and CV morta...
Source: Cardiovascular Diabetology - July 17, 2023 Category: Cardiology Authors: El żbieta Paszek, Maciej Polak, Agata Hanna Bryk-Wiązania, Małgorzata Konieczyńska and Anetta Undas Tags: Research Source Type: research