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Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes
In conclusion, α-MSH is neuroprotective under hyperglycemic condition against I/R induced brain damage by its anti-inflammatory, anti-oxidative and anti-apoptotic properties. The use of α-MSH analogues may be potential therapeutic agents for diabetic stroke.PMID:34586586 | DOI:10.1007/s11064-021-03453-4
Source: Neurochemical Research - September 29, 2021 Category: Neuroscience Authors: Rajesh Kumar Goit Tsz Chung Ng Ka Cheung Tam Jessica K W Tsang Andrew W Taylor Amy C Y Lo Source Type: research

Vessel Dilation Attenuates Endothelial Dysfunction Following Middle Cerebral Artery Occlusion in Hyperglycemic Rats.
CONCLUSIONS: Our dynamic angiographic data demonstrated that diabetes could impair the cerebral arterial reactivity. Prolonged fasudil treatment could attenuate arterial dysfunction and improve the prognosis of ischemic stroke by affecting both the large and small vasculature. PMID: 26842484 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Mu ZH, Jiang Z, Lin XJ, Wang LP, Xi Y, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research