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A Critical Role for ERO1 α in Arterial Thrombosis and Ischemic Stroke
CONCLUSIONS: Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.PMID:37132383 | DOI:10.1161/CIRCRESAHA.122.322473
Source: Cell Research - May 3, 2023 Category: Cytology Authors: Vishwanath Jha Bei Xiong Tripti Kumari Gavriel Brown Jinzhi Wang Kyungho Kim Jingu Lee Nathan Asquith John Gallagher Lillian Asherman Taylor Lambert Yanyan Bai Xiaoping Du Jeong-Ki Min Rajan Sah Ali Javaheri Babak Razani Jin-Moo Lee Joseph E Italiano Jaeh Source Type: research

Platelets, Macrophages, and Thromboinflammation in Chagas Disease
J Inflamm Res. 2022 Oct 4;15:5689-5706. doi: 10.2147/JIR.S380896. eCollection 2022.ABSTRACTChagas disease (CD) is a major health problem in the Americas and an emerging health problem in Europe and other nonendemic countries. Several studies have documented persistence of the protozoan parasite Trypanosoma cruzi, and oxidative and inflammatory stress are major pathogenic factor. Mural and cardiac thrombi, cardiac arrhythmias, and cardiomyopathy are major clinical features of CD. During T. cruzi infection, parasite-released factors induce endothelial dysfunction along with platelet (PLT) and immune-cell activation. PLTs hav...
Source: Cell Research - October 11, 2022 Category: Cytology Authors: Subhadip Choudhuri Nisha J Garg Source Type: research

Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Cell Mol Life Sci. 2022 Apr 13;79(5):240. doi: 10.1007/s00018-022-04257-7.ABSTRACTIschemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strategy to control ischemic stroke. Here, a plasma kallikrein and active FXII (FXIIa) inhibitor (sylvestin, contained 43 amino acids, with a molecular weight of 4790.4 Da) was first identified from fore...
Source: Cellular and Molecular Life Sciences : CMLS - April 13, 2022 Category: Cytology Authors: Zhiye Zhang Chuanbin Shen Mingqian Fang Yajun Han Chengbo Long Weihui Liu Min Yang Ming Liu Dengdeng Zhang Qiqi Cao Xue Chen Yaqun Fang Qiumin Lu Zongliu Hou Yaxiong Li Zhenze Liu Xi Lei Heyu Ni Ren Lai Source Type: research

The Clot Thickens: Recent Clues on Hematopoietic Stem Cell Contribution to Age-Related Platelet Biology Open New Questions
Adv Geriatr Med Res. 2021;3(4):e210019. doi: 10.20900/agmr20210019. Epub 2021 Oct 28.ABSTRACTPlatelets provide life-saving functions by halting external and internal bleeding. There is also a dark side to platelet biology, however. Recent reports provide evidence for increased platelet reactivity during aging of mice and humans, making platelets main suspects in the most prevalent aging-related human pathologies, including cardiovascular diseases, stroke, and cancer. What drives this platelet hyperreactivity during aging? Here, we discuss how hematopoietic stem cell differentiation pathways into the platelet lineage offer ...
Source: Cell Research - January 17, 2022 Category: Cytology Authors: Donna M Poscablo E Camilla Forsberg Source Type: research

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage.
CONCLUSION:: Serum levels of LDL was a protective factor. NAFLD did not increase the unfavorable outcome of ICH patients in our study. PMID: 30922067 [PubMed - as supplied by publisher]
Source: Cell Transplantation - March 28, 2019 Category: Cytology Authors: Tu S, Zhao R, Fang H, Wang L, Shao A, Sheng J Tags: Cell Transplant Source Type: research