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Association between periodontal diseases and systemic illnesses: A survey among internal medicine residents in Nigeria
Conclusions Knowledge of periodontal disease as a risk factor for systemic illnesses among medical residents in Nigeria is inadequate. These relationships should be emphasized in continuing medical education courses.
Source: The Saudi Dental Journal - November 10, 2015 Category: Dentistry Source Type: research

The Risk Stratification and Stroke Prevention Therapy Care Gap in Canadian Atrial Fibrillation Patients
Conclusions In a large Canadian AF population, primary care physicians did not provide a stroke or bleeding risk in a substantial proportion of their AF patients. When estimates were provided, they were on the basis of a predictive stroke and bleeding risk index in less than half of the patients. Furthermore, there was under- and overestimation of stroke and bleeding risk in a substantial proportion of patients. As many as 1 in 3 patients receiving warfarin have their TTR < 60%. These findings suggest an opportunity to enhance knowledge translation to primary care physicians.
Source: Canadian Journal of Cardiology - October 23, 2015 Category: Cardiology Source Type: research

Vicky's Story
My older sister, Vicky, never listened to authority. One of my earliest childhood memories was around age four, seeing my Mom whip Vicky with a long tree twig to the point she was bleeding. My mother, a frustrated widow raising five girls on meager Social Security benefits in rural southeast Missouri used the only form of discipline she knew -- corporal punishment. As Vicky's 10-year-old old legs, back, and buttocks became covered in red dotted lines, she never cried or moaned. Instead she looked straight ahead, stone-faced. Mom perceived her look as defiance and gave her more lashings than she should have that day. Event...
Source: Healthy Living - The Huffington Post - July 31, 2015 Category: Consumer Health News Source Type: news

Delay of Percutaneous Gastrostomy Tube (PEG) Placement in Patients with Ischemic Stroke in a Large Urban Hospital. (P1.063)
CONCLUSIONS: Our study shows that hypertension, use of AA agents and use of tPA puts stroke patients at risk of having a delay in PEG placement. Prior studies have shown that aspirin use is not associated with increased bleeding complications during PEG placement. Education can help avoid delay in PEG tube placement due to aspirin use. Early PEG placement in ischemic stroke patients may improve clinical outcome and decrease hospital costs.Disclosure: Dr. Raval has nothing to disclose. Dr. Rayi has nothing to disclose. Dr. Jacob has nothing to disclose. Dr. Hillen has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Raval, B., Rayi, A., Jacob, M., Hillen, M. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

Stroke Awareness In Outpatients. (P2.302)
CONCLUSIONS: General knowledge about CVRF is still insufficient in the outpatient population, even when assessed in the cardiology or neurology clinic. We believe that increased knowledge about stroke in outpatients, compared to inpatients, is due to higher educational level and a higher amount of family members with a history of stroke. Study Supported by:Disclosure: Dr. Pagani Cassara has nothing to disclose. Dr. Gonzalez Toledo has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Pagani Cassara has nothing to disclose. Dr. Moschini has nothing to disclose. ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Nadile, D., Gonzalez Toledo, M., Gomez, Y., Munoz Giacomelli, F., Delfitto, M., Moschini, J., Pagani Cassara, F., Tamargo, A., Thomson, A., Klein, F. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Transient ischemic attacks in post-menopausal women with history of migraines have lower risk for subsequent ischemic strokes (P2.306)
CONCLUSIONS: The risk of ischemic stroke is lower following TIA in women with migraine history (compared with those without migraine) suggesting potentially different pathophysiology in such women.Disclosure: Dr. Rahman has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Thomas has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rahman, H., Malik, A., Thomas, A., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events (P6.241)
Conclusion- Patient’s knowledge about OAT was suboptimal. The findings support the need for educational interventions to improve the knowledge regarding oral anticoagulation therapy, and thereby achieve an appropriate and safe secondary prevention of stroke.Disclosure: Dr. Bhatia has nothing to disclose. Dr. Alphonsa has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bhatia, R., Alphonsa, A., Sharma, K., Sharma, G. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

How are patients with atrial fibrillation approached and informed about their risk profile and available therapies in Europe? Results of the European Heart Rhythm Association Survey
This European Heart Rhythm (EHRA) Scientific Initiatives Committee EP Wire Survey aimed at exploring the common practices in approaching patients with atrial fibrillation (AF) and informing them about their risk profiles and available therapies in Europe. In the majority of 53 responding centres, patients were seen by cardiologists (86.8%) or arrhythmologists (64.2%). First- and follow-up visits most commonly lasted 21–30 and 11–20 min (41.5 and 69.8% of centres, respectively). In most centres (80.2%) stroke and bleeding risk had the highest priority for discussion with AF patients; 50.9% of centres had a struc...
Source: Europace - February 26, 2015 Category: Cardiology Authors: Potpara, T. S., Pison, L., Larsen, T. B., Estner, H., Madrid, A., Blomstrom-Lundqvist, C., Conducted by the Scientific Initiatives Committee, and European Heart Rhythm Association, Conducted by the Scientific Initiatives Committee, and European Heart Rhyt Tags: EP WIRE Source Type: research

Reversing targeted oral anticoagulants.
Authors: Hoffman M, Monroe DM Abstract Dabigatran, rivaroxaban, and apixaban are orally active anticoagulants that are approved in many countries. Dabigatran inhibits thrombin, whereas rivaroxaban and apixaban are factor Xa inhibitors. In clinical trials, these novel oral anticoagulants were at least as effective as warfarin for preventing stroke in patients with atrial fibrillation, but with a lower rate of serious bleeding. However, the lack of true antidotes for these agents has caused concern when patients suffer life-threatening bleeding or trauma or require emergent invasive procedures. True antidotes are und...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Epidemiologic and clinical data linking factors XI and XII to thrombosis.
Authors: Key NS Abstract Currently available evidence supports the contention that elevated levels of factor XI (fXI) are associated with a greater risk of venous thromboembolism and ischemic stroke, but, less convincingly, with myocardial infarction. Conversely, reduced plasma levels of fXI seem to offer some protection from venous thromboembolism and stroke, but not myocardial infarction. Factor XI-deficient patients are at risk for certain types of bleeding, particularly posttraumatic hemorrhage on mucosal surfaces where there is a high endogenous fibrinolytic activity. In contrast, the situation with fXII in hu...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Future prospects for contact factors as therapeutic targets.
Authors: Gailani D Abstract Anticoagulants currently used in clinical practice to treat or prevent thromboembolic disease are effective, but place patients at increased risk for serious bleeding because they interfere with plasma enzymes (thrombin and factor Xa) that are essential for hemostasis. In the past 10 years, work with genetically altered mice and studies in baboons and rabbits have demonstrated that the plasma contact proteases factor XI, factor XII, and prekallikrein contribute to the formation of occlusive thrombi despite having limited roles in hemostasis. In the case of factor XI, epidemiologic data f...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Monitoring target-specific oral anticoagulants.
Authors: Konkle BA Abstract Target-specific oral anticoagulants are approved for use for the prevention of stroke in atrial fibrillation and for the prevention and treatment of venous thrombosis without the need for laboratory monitoring. However, there are clinical settings in which laboratory measurement of anticoagulant effect is needed. These may include patients with life-threatening bleeding or those requiring emergency surgery, in the setting of renal or hepatic failure, or patients with thrombosis on therapy. This chapter reviews the use of laboratory testing to assess the anticoagulant effect of these drug...
Source: Hematology ASH Education Program - February 20, 2015 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Selection of Warfarin or One of the New Oral Antithrombotic Agents for Long-Term Prevention of Stroke among Persons with Atrial Fibrillation
Opinion statement Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder, which can potentially increases the risk of stroke by five-fold, thus, resulting in high public healthcare burden. Stroke prevention is vital in the management of AF patients. Vitamin K antagonists (VKA, eg, warfarin) have been the mainstay treatment to prevent ischemic stroke and systemic thromboembolism in AF patients for several decades. Despite the efficacy of warfarin, its limitations have recently driven the advent of some new antithrombotic agents, the non-VKA oral anticoagulant (NOACs, including dabigatran, ri...
Source: Current Treatment Options in Neurology - February 11, 2015 Category: Neurology Source Type: research

Memory gaps in graduates a 'stroke warning sign'
Conclusion This study showed that highly educated people who notice memory complaints in themselves may be more likely to develop stroke than those who don’t, over an average of 12 years. The study had a number of strengths, such as its population-based prospective design and availability of data on more than 9,000 participants at baseline with a long follow-up. However, there were also a number of limitations that weaken the strength of the conclusions. It was not clear whether the memory complaints were assessed just once at the start of the study or an ongoing basis. Some people may report memory complaints that are o...
Source: NHS News Feed - December 12, 2014 Category: Consumer Health News Tags: Neurology Mental health Older people Source Type: news

Association of the 2011 ACGME Resident Duty Hour Reforms With Mortality and Readmissions Among Hospitalized Medicare Patients
Conclusions and RelevanceAmong Medicare beneficiaries, there were no significant differences in the change in 30-day mortality rates or 30-day all-cause readmission rates for those hospitalized in more intensive relative to less intensive teaching hospitals in the year after implementation of the 2011 ACGME duty hour reforms compared with those hospitalized in the 2 years before implementation.
Source: JAMA - December 10, 2014 Category: Journals (General) Source Type: research

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