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Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Does happiness itself directly affect mortality? The prospective UK Million Women Study
Publication date: Available online 10 December 2015 Source:The Lancet Author(s): Bette Liu, Sarah Floud, Kirstin Pirie, Jane Green, Richard Peto, Valerie Beral Background Poor health can cause unhappiness and poor health increases mortality. Previous reports of reduced mortality associated with happiness could be due to the increased mortality of people who are unhappy because of their poor health. Also, unhappiness might be associated with lifestyle factors that can affect mortality. We aimed to establish whether, after allowing for the poor health and lifestyle of people who are unhappy, any robust evidence remai...
Source: The Lancet - December 12, 2015 Category: Journals (General) Source Type: research

Welcome To My World, Dr. Oz
Dr. Oz and I must be doing something right – otherwise, we wouldn’t incur the wrath of the medical establishment, Big Pharma and Big Agra. Recently, 10 doctors lobbied Columbia University to oust celebrity physician Mehmet Oz from the distinguished university’s hospital and its department of health sciences and medicine. In a letter to the department’s dean of faculty, the doctors attacked him for presenting alternative and natural cures on his syndicated TV program, The Dr. Oz Show. They also chastised him for being concerned about genetically modified crops. Welcome to my world, Dr. Oz. Since graduati...
Source: Al Sears, MD Natural Remedies - May 12, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition DHA Dr. Oz Show EPA omega 3 Source Type: news