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NAFLD in Cardiovascular Diseases: A Contributor or Comorbidity?
In conclusion, a more comprehensive, multidisciplinary approach to diagnosis and management of patients with NAFLD and cardiovascular diseases is needed to optimize clinical outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Liver Disease - October 14, 2022 Category: Gastroenterology Authors: Chen, Bing Tang, W.H Wilson Rodriguez, Mario Corey, Kathleen E. Sanyal, Arun J. Kamath, Patrick S. Bozkurt, Biykem Virk, Hafeez Ul Hassan Pressman, Gregg S. Lazarus, Jeffrey V. El-Serag, Hashem B. Krittanawong, Chayakrit Tags: Review Article Source Type: research

Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic Syndrome
Horm Metab Res DOI: 10.1055/a-1510-8896Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient ins...
Source: Hormone and Metabolic Research - June 30, 2021 Category: Endocrinology Authors: Rohner, Markus Heiz, Robert Feldhaus, Simon Bornstein, Stefan R. Tags: Endocrine Care Source Type: research

The Discovery and Development of Liraglutide and Semaglutide
We describe one such approach, albumin binding, and explain how it was applied in the development of the human GLP-1 analog liraglutide once daily and, subsequently, semaglutide once weekly. The pharmacology of these two long-acting GLP-1 analogs, in terms of improving glycemic control, reducing body weight and decreasing cardiovascular (CV) risk, is also reviewed, together with some novel biology. In addition, we describe the importance of accurate target (GLP-1 receptor) tissue expression analysis. Now an established class of agents, GLP-1-based therapies represent a significant advance in the treatment of T2D. All curr...
Source: Frontiers in Endocrinology - April 11, 2019 Category: Endocrinology Source Type: research

10 Ways to Keep Your Heart Healthy
No one ever had fun visiting the cardiologist. ­Regardless of how good the doc might be, it’s always a little scary thinking about the health of something as fundamental as the heart. But there are ways to take greater control—to ensure that your own heart health is the best it can be—even if you have a family history of cardiovascular disease. Although 50% of cardiovascular-disease risk is genetic, the other 50% can be modified by how you live your life, according to Dr. Eugenia Gianos, director of Women’s Heart Health at Lenox Hill Hospital in New York City. “This means you can greatly ...
Source: TIME: Health - October 17, 2018 Category: Consumer Health News Authors: Lisa Lombardi and Jamie Ducharme Tags: Uncategorized Baby Boomer Health heart health Source Type: news

Weight Loss in Italy?
One of the women I work with wanted to know about the new diet drug called Belviq. The FDA is always approving a new “miracle” weight-loss pill, only to recall it a few years later. To date, at least 34 diet drugs have been taken off the market. Diet pills cause all kinds of problems — heart attack, stroke and psychiatric disorders. And Belviq isn’t any different. Some of its side effects include suicidal thoughts, a racing heartbeat, hallucinations and more… The European Union banned Belviq. The reason? It causes cancer in animals.  And here’s the real irony… Clinical trials found ...
Source: Al Sears, MD Natural Remedies - October 19, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Anti-Aging Source Type: news

What Are Endoscopic Bariatric Therapies?
The high prevalence of overweight and obesity in the United States negatively affects the health of the population. Obesity increases the risk of various diseases, including diabetes mellitus, hypertension, coronary heart disease, sleep apnea, stroke, gatroesophageal reflux disease, gall bladder disease, certain types of malignancy, and non-alcoholic fatty liver diseases.1,2 Reducing obesity in the United States has become a public health priority.1,2 Current approaches to therapeutic weight loss include dietary approaches, lifestyle intervention, pharmacology, and surgery.
Source: Journal of the American Dietetic Association - January 25, 2017 Category: Nutrition Authors: Wendy Marcason Tags: From the Academy Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

You Don't Need To Lose A Lot Of Weight To Start Seeing Health Benefits
This study clarifies conventional wisdom among obesity experts, who have traditionally advised patients to lose 5 to 10 percent of their body weight in order to improve blood pressure, cholesterol and blood sugar levels. But as anyone who has ever tried to lose weight can attest, there is a big difference between 5 percent and 10 percent.   "That’s a very vague, wide range," Klein said. "It’s much harder to achieve a 10 percent weight loss than it is to achieve a five percent weight loss." Klein said his study shows that even just a little bit of weight loss is enough to improve health, and that peopl...
Source: Science - The Huffington Post - February 23, 2016 Category: Science Source Type: news

Study finds obese people may struggle to reach a healthy weight
ConclusionThis research makes use of a general practice database providing just under 10 years of BMI observations for a large, nationally representative UK sample. It demonstrates that low proportions of people in the obese categories were able to achieve a normal BMI over a year of follow-up, and the common problem of weight cycling. However, there are points to consider when interpreting these results: The probability of obtaining a normal BMI over a year was very low: only 1 in 210 for men and 1 in 124 for women in the "simple obese" category of 30 to 35kg/m2, and much lower than that for the higher categor...
Source: NHS News Feed - July 20, 2015 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news