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Modification of ventriculo –arterial coupling by spironolactone in nonischemic dilated cardiomyopathy
ConclusionsIn NIDCM, adding MRA to conventional anti ‐failure therapy markedly improved LV ejection fraction and reduced peripheral vascular resistance, due to both improved LV contractility and especially to enhanced V–A coupling, as Ea decreased to normal. Total circulatory performance was a sensitive indicator of both LV pump performance and th e arterial loading conditions.
Source: ESC Heart Failure - March 29, 2021 Category: Cardiology Authors: Mark A. Lawson, David E. Hansen, Deepak K. Gupta, Susan P. Bell, Douglas W. Adkisson, Ravinder R. Mallugari, Douglas B. Sawyer, Henry Ooi, Marvin W. Kronenberg Tags: Original Research Article Source Type: research

Myocardial fibrosis in stroke survivors
Stroke survivors are most likely to die of cardiac death, yet few undergo comprehensive cardiac assessment to look for reversible causes. Myocardial fibrosis (MF) is not only the hallmark of cardiomyopathy, but also a substrate for sudden cardiac death, ventricular tachyarrhythmia and heart failure. Procollagen carboxyl-terminal telopeptide (PICP) was found to be a marker of MF. The relationship between PICP and cardiac abnormalities in stroke survivors is unknown. We recently showed that MF in stroke survivors can be treated by spironolactone and amiloride in a randomised placebo-controlled cross-over study with reduction...
Source: International Journal of Cardiology - March 19, 2015 Category: Cardiology Authors: K. Wong, S. Sze, S. Wong, S. McSwiggan, V. Allgar, R. MacWalter, A.D. Struthers Tags: Letter to editor Source Type: research