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Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Authors: Allardet-Servent J, Sicard G, Metz V, Chiche L Abstract Oxygen therapy is used to reverse hypoxemia since more than a century. Current usage is broader and includes routine oxygen administration despite normoxemia which may result in prolonged periods of hyperoxemia. While systematic oxygen therapy was expected to be of benefit in some ischemic diseases such as stroke or acute myocardial infarction, recent randomised controlled trials (RCTs) have challenged this hypothesis by showing the absence of clinical improvement. Although oxygen is known to be toxic at high inspired oxygen fractions, a recent meta-a...
Source: Revue de Medecine Interne - May 7, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Association between ischemic stroke and carbon monoxide poisoning: A population-based retrospective cohort analysis.
CONCLUSION: CO poisoning is associated with a long-term risk of increased incident ischemic stroke. Further study on the mechanism of ischemic stroke for CO poisoning affects is needed. PMID: 26703428 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - December 15, 2015 Category: Internal Medicine Authors: Lin CW, Chen WK, Hung DZ, Chen YW, Lin CL, Sung FC, Kao CH Tags: Eur J Intern Med Source Type: research

The medical use of oxygen: a time for critical reappraisal
Abstract Oxygen treatment has been a cornerstone of acute medical care for numerous pathological states. Initially, this was supported by the assumed need to avoid hypoxaemia and tissue hypoxia. Most acute treatment algorithms, therefore, recommended the liberal use of a high fraction of inspired oxygen, often without first confirming the presence of a hypoxic insult. However, recent physiological research has underlined the vasoconstrictor effects of hyperoxia on normal vasculature and, consequently, the risk of significant blood flow reduction to the at‐risk tissue. Positive effects may be claimed simply by relief of a...
Source: Journal of Internal Medicine - November 11, 2013 Category: Internal Medicine Authors: F. Sjöberg, M. Singer Tags: Review Source Type: research