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Intracranial artery stenosis is associated with cortical thinning in stroke-free individuals of two longitudinal cohorts
CONCLUSION: We found both radiographically and neuropathologically determined aICAS to be associated with global cortical thinning. Interestingly, posterior circulation stenoses appeared to drive this association with global cortical thinning, raising the possibility of pathophysiologic mechanisms for cortical thinning other than impaired hemodynamics.PMID:36577280 | DOI:10.1016/j.jns.2022.120533
Source: Atherosclerosis - December 28, 2022 Category: Cardiology Authors: Dixon Yang Arjun V Masurkar Farid Khasiyev Tatjana Rundek Clinton B Wright Mitchell S V Elkind Ralph L Sacco Jose Gutierrez Source Type: research

MarkVCID cerebral small vessel consortium: II. Neuroimaging protocols.
Authors: Lu H, Kashani AH, Arfanakis K, Caprihan A, DeCarli C, Gold BT, Li Y, Maillard P, Satizabal CL, Stables L, Wang DJJ, Corriveau RA, Singh H, Smith EE, Fischl B, van der Kouwe A, Schwab K, Helmer KG, Greenberg SM, MarkVCID Consortium Abstract The MarkVCID consortium was formed under cooperative agreements with the National Institute of Neurologic Diseases and Stroke (NINDS) and National Institute on Aging (NIA) in 2016 with the goals of developing and validating biomarkers for the cerebral small vessel diseases associated with the vascular contributions to cognitive impairment and dementia (VCID). Rigorously ...
Source: The Journal of Alzheimers Association - January 24, 2021 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review
Conclusions: Changes in retinal microvasculature identified using OCTA are associated with monogenic SVD and different stages of AD, but data are limited and partly confounded by methodological differences. Larger studies with risk factors adjustment and more consistent OCTA methods are needed to fully exploit this technology.PROSPERO registration number: CRD42020166929.
Source: Frontiers in Neurology - September 9, 2020 Category: Neurology Source Type: research

Correlation Between Intracranial Arterial Calcification and Imaging of Cerebral Small Vessel Disease
Conclusion: Intracranial artery calcification is common in patients with ischemic cerebrovascular disease and the intracranial carotid artery is most frequently affected. Intracranial arterial calcifications might be associated with imaging markers of SVD and are highly correlated with WMHs, lacunes, and CMBs. Quantification of calcification on CT provides additional information on the pathophysiology of SVD. Intracranial arterial calcification could act as a potential marker of SVD. Introduction Atherosclerosis is a systemic vascular process that is considered a major cause of cerebrovascular and cardiovascular di...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory
Conclusion: Consecutive slides on axial view (≥4 consecutive slices) might be more effective than transversal diameter to identify the atherosclerotic mechanisms of SSIs in the lenticulostriate artery territory. Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT00664846 Introduction Single subcortical infarctions (SSIs) have been considered to be caused by lipohyalinosis degeneration in small artery disease, traditionally called lacunar infarct (1). However, atherosclerosis occurring in the parental artery blocking the orifice of the branch artery or atherosclerosis in the p...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease
Conclusions: Intracranial arterial stenosis increased the risk of developing AD dementia after MCI.
Source: Neurology - March 10, 2014 Category: Neurology Authors: Zhu, J., Wang, Y., Li, J., Deng, J., Zhou, H. Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Alzheimer's disease, MCI (mild cognitive impairment) ARTICLE Source Type: research

Teaching NeuroImages: Treatment-resistant rapidly progressive amyloid {beta}-related angiitis
A 76-year-old woman presented with 1 month of progressive aphasia, headache, and subsequent right hemiparesis. Initial brain MRI showed a punctate infarct (figure 1, A and C). Susceptibility-weighted imaging was unremarkable. A repeat study 16 days later demonstrated bihemispheric infarcts with multifocal attenuation of intracranial vessels on magnetic resonance angiography (figure 1, B and D). CSF showed a lymphocytic pleocytosis (101 leukocytes/µL) and elevated protein (480 mg/dL). Brain biopsy showed granulomatous angiitis with amyloid deposition and fibrinoid necrosis surrounded by inflammatory cells (figure 2). ...
Source: Neurology - April 29, 2013 Category: Neurology Authors: Porter, M., Newey, C. R., Toth, G. Tags: MRI, Other cerebrovascular disease/ Stroke, Alzheimer's disease, Infarction RESIDENT AND FELLOW SECTION Source Type: research

Prevalence of Cerebrovascular Events in Extraluminal Protruding Intracranial Atherosclerotic Plaques: Analysis of Intracranial Vessels from the Nun Study (P03.009)
CONCLUSIONS: Outside protruding plaques without angiographic stenosis appear to be responsible for ischemic events in patients with cryptogenic stroke. Higher prevalence of stroke in these patients warrants the use of newer imaging modalities like high resolution magnetic resonance imaging to identify patients who are at high risk of cerebrovascular events.Disclosure: Dr. Semaan has nothing to disclose. Dr. Majidi has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Santa Cruz has nothing to disclose. Dr. Suri has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Semaan, E., Majidi, S., Chaudhry, S., Santa Cruz, K., Suri, M. F., Qureshi, A. Tags: P03 Child Neurology II Source Type: research