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Neuroinductive properties of mGDNF depend on the producer, < i > E < /i > . < i > Coli < /i > or human cells
by Dzhirgala V. Shamadykova, Dmitry Y. Panteleev, Nadezhda N. Kust, Ekaterina A. Savchenko, Ekaterina Y. Rybalkina, Alexander V. Revishchin, Galina V. Pavlova The glial cell line‐derived neurotrophic factor (GDNF) is involved in the survival of dopaminergic neurons. Besides, GDNF can also induce axonal growth and creation of new functional synapses. GDNF potential is promising for translation to treat diseases associated with neuronal death: neurodege nerative disorders, ischemic stroke, and cerebral or spinal cord damages. Unproductive clinical trials of GDNF for Parkinson’s disease treatment have induced to study th...
Source: PLoS One - October 11, 2021 Category: Biomedical Science Authors: Dzhirgala V. Shamadykova Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

{Delta}9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPAR{gamma} DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE
Conclusions Even though 9–THC and pioglitazone are both protective against MPP+ only 9–THC induces PPAR dependent mitochondrial biogenesis, a mechanism that may be beneficial for the treatment of PD.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Zeissler, M.-L., Eastwood, J., Oliver Hanemann, C., Zajicek, J., Carroll, C. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Parkinson's disease, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research